Carbohydrate-active enzymes (CAZymes) in the gut microbiome

7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins

(2021) Andreas Geissner et al.   ACS Central Science

Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis

(2021) Benjamin Pluvinage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On-demand biomanufacturing of protective conjugate vaccines

(2021) Jessica C. Stark et al.   Science Advances

N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes

(2021) Melanie A. Higgins et al.   ACS Chemical Biology

Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity

(2021) Chao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen

(2021) Jacob F. Wardman et al.   ACS Chemical Biology

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

(2021) Omar Delannoy-Bruno et al.   NATURE

A single sulfatase is required to access colonic mucin by a gut bacterium

(2021) Ana S. Luis et al.   NATURE

Glycosynthase reaction meets the flow: Continuous synthesis of lacto‐ N ‐triose II by engineered β‐hexosaminidase immobilized on solid support

(2020) Lucija Ruzic et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sequential Glycosylation of Proteins with Substrate-Specific N-Glycosyltransferases

(2020) Liang Lin et al.   ACS Central Science

Selective N-glycan editing on living cell surfaces to probe glycoconjugate function

(2020) Feng Tang et al.   Nature Chemical Biology

Trefoil factors share a lectin activity that defines their role in mucus

(2020) Michael A. Järvå et al.   Nature Communications

An Epoxide Intermediate in Glycosidase Catalysis

(2020) Lukasz F. Sobala et al.   ACS Central Science

Engineering orthogonal human O-linked glycoprotein biosynthesis in bacteria

(2020) Aravind Natarajan et al.   Nature Chemical Biology

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

(2020) Lucy I. Crouch et al.   Nature Communications

Synthetic Glycobiology: Parts, Systems, and Applications

(2020) Weston Kightlinger et al.   ACS Synthetic Biology

An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins

(2020) D. Judy Shon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins

(2020) M. Florencia Haurat et al.   mBio

Investigating host-microbiome interactions by droplet based microfluidics

(2020) Alexandra S. Tauzin et al.   Microbiome

Communal living: glycan utilization by the human gut microbiota

(2020) Jonathon A. Briggs et al.   ENVIRONMENTAL MICROBIOLOGY

N-Glycan Utilization by Bifidobacterium Gut Symbionts Involves a Specialist β-Mannosidase

(2019) Rosa Lorizolla Cordeiro et al.   JOURNAL OF MOLECULAR BIOLOGY

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Priorities for the next 10 years of human microbiome research

(2019) Lita Proctor   NATURE

The ancestral and industrialized gut microbiota and implications for human health

(2019) Erica D. Sonnenburg et al.   NATURE REVIEWS MICROBIOLOGY

Glycosynthase Principle Transformed into Biocatalytic Process Technology: Lacto-N-triose II Production with Engineered exo-Hexosaminidase

(2019) Katharina Schmölzer et al.   ACS Catalysis

Influenza A virus surface proteins are organized to help penetrate host mucus

(2019) Michael D Vahey et al.   eLife

Mapping human microbiome drug metabolism by gut bacteria and their genes

(2019) Michael Zimmermann et al.   NATURE

Bacteroidetes use thousands of enzyme combinations to break down glycans

(2019) Pascal Lapébie et al.   Nature Communications

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

(2019) Justina Briliūtė et al.   Nature Microbiology

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood

(2019) Peter Rahfeld et al.   Nature Microbiology

High-Throughput Recovery and Characterization of Metagenome-Derived Glycoside Hydrolase-Containing Clones as a Resource for Biocatalyst Development

(2019) Zachary Armstrong et al.   mSystems

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates

(2019) Livia S. Zaramela et al.   Nature Microbiology

Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure

(2019) Benjamin C. Creekmore et al.   mSystems

Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases

(2019) Samantha M. Ervin et al.   ACS Chemical Biology

Prospecting for microbial α-N-acetylgalactosaminidases yields a new class of GH31 O-glycanase

(2019) Peter Rahfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starch Digestion by Gut Bacteria: Crowdsourcing for Carbs

(2019) Filipe M. Cerqueira et al.   TRENDS IN MICROBIOLOGY

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

(2019) Emily R Leeming et al.   Nutrients

Chemoenzymatic synthesis of glycoproteins

(2019) Antony J Fairbanks   CURRENT OPINION IN CHEMICAL BIOLOGY

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Glycan-metabolizing enzymes in microbe-host interactions: the Streptococcus pneumoniae paradigm

(2018) Joanne K. Hobbs et al.   FEBS LETTERS

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

(2018) Eric C. Martens et al.   NATURE REVIEWS MICROBIOLOGY

Why does the microbiome affect behaviour?

(2018) Katerina V.-A. Johnson et al.   NATURE REVIEWS MICROBIOLOGY

Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation

(2018) Chiu-Ping Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont

(2018) Benjamin Pluvinage et al.   Nature Communications

Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

(2018) Samuel J. Pellock et al.   ACS Central Science

Dietary trehalose enhances virulence of epidemic Clostridium difficile

(2018) J. Collins et al.   NATURE

US Immigration Westernizes the Human Gut Microbiome

(2018) Pajau Vangay et al.   CELL

Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

(2018) John P. Giddens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide

(2018) Maja Napiórkowska et al.   Scientific Reports

A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation

(2018) Alan Cartmell et al.   Nature Microbiology

Surface Exposure and Packing of Lipoproteins into Outer Membrane Vesicles Are Coupled Processes in Bacteroides

(2018) Ezequiel Valguarnera et al.   mSphere

Production of HMOs using microbial hosts — from cell engineering to large scale production

(2018) Katrine Bych et al.   CURRENT OPINION IN BIOTECHNOLOGY

Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes

(2017)   GLYCOBIOLOGY

Polysaccharide Utilization Loci: Fueling Microbial Communities

(2017) Julie M. Grondin et al.   JOURNAL OF BACTERIOLOGY

Glucuronides in the gut: Sugar-driven symbioses between microbe and host

(2017) Samuel J. Pellock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akkermansia muciniphila and its role in regulating host functions

(2017) Muriel Derrien et al.   MICROBIAL PATHOGENESIS

Physiological and Molecular Understanding of Bacterial Polysaccharide Monooxygenases

(2017) Marco Agostoni et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structural basis for nutrient acquisition by dominant members of the human gut microbiota

(2017) Amy J. Glenwright et al.   NATURE

Complex pectin metabolism by gut bacteria reveals novel catalytic functions

(2017) Didier Ndeh et al.   NATURE

PULDB: the expanded database of Polysaccharide Utilization Loci

(2017) Nicolas Terrapon et al.   NUCLEIC ACIDS RESEARCH

How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans

(2017) Alan Cartmell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of protein-linked glycans as a determinant of peptidase activity

(2017) Ilit Noach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania

(2017) Samuel A. Smits et al.   SCIENCE

An Atlas of β-Glucuronidases in the Human Intestinal Microbiome

(2017) Rebecca M. Pollet et al.   STRUCTURE

Unraveling the processes shaping mammalian gut microbiomes over evolutionary time

(2017) Mathieu Groussin et al.   Nature Communications

Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides

(2017) Kazune Tamura et al.   Cell Reports

Emergency transfusion of patients with unknown blood type with blood group O Rhesus D positive red blood cell concentrates: a prospective, single-centre, observational study

(2017) Kathleen Selleng et al.   Lancet Haematology

Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides

(2017) Ana S. Luis et al.   Nature Microbiology

Advances in Enzymatic Glycoside Synthesis

(2016) Phillip M. Danby et al.   ACS Chemical Biology

Optimal Synthetic Glycosylation of a Therapeutic Antibody

(2016) Thomas B. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota

(2016) A. Benjdia et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

(2016) Mark R. Charbonneau et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

The evolution of cooperation within the gut microbiota

(2016) Seth Rakoff-Nahoum et al.   NATURE

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Glycoside Hydrolases across Environmental Microbial Communities

(2016) Renaud Berlemont et al.   PLoS Computational Biology

Unusual sub-genus associations of faecal Prevotella and Bacteroides with specific dietary patterns

(2016) Francesca De Filippis et al.   Microbiome

Carbon–carbon bond cleavage and formation reactions in drug metabolism and the role of metabolic enzymes

(2015) Jayaprakasam Bolleddula et al.   DRUG METABOLISM REVIEWS

Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults

(2015) Julien Tap et al.   ENVIRONMENTAL MICROBIOLOGY

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

(2015) Fiona Cuskin et al.   NATURE

Towards a more comprehensive concept for prebiotics

(2015) Laure B. Bindels et al.   Nature Reviews Gastroenterology & Hepatology

Glycan-Foraging Systems Reveal the Adaptation of Capnocytophaga canimorsus to the Dog Mouth

(2015) Francesco Renzi et al.   mBio

Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans

(2015) N. A. Pudlo et al.   mBio

Glycan complexity dictates microbial resource allocation in the large intestine

(2015) Artur Rogowski et al.   Nature Communications

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Old Drug New Use--Amoxapine and Its Metabolites as Potent Bacterial  -Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity

(2014) R. Kong et al.   CLINICAL CANCER RESEARCH

Structural insights into bacterial recognition of intestinal mucins

(2014) Sabrina Etzold et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal Structure of a Bacterial Unsaturated Glucuronyl Hydrolase with Specificity for Heparin

(2014) Yusuke Nakamichi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Devil Lies in the Details: How Variations in Polysaccharide Fine-Structure Impact the Physiology and Evolution of Gut Microbes

(2014) Eric C. Martens et al.   JOURNAL OF MOLECULAR BIOLOGY

Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium

(2014) Varsha Raghavan et al.   MOLECULAR MICROBIOLOGY

Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections

(2014) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unusual Enzymatic Glycoside Cleavage Mechanisms

(2013) Seino A. K. Jongkees et al.   ACCOUNTS OF CHEMICAL RESEARCH

An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts

(2013) Seth Rakoff-Nahoum et al.   CURRENT BIOLOGY

Discovery of β-1,4-d-Mannosyl-N-acetyl-d-glucosamine Phosphorylase Involved in the Metabolism ofN-Glycans

(2013) Takanori Nihira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

(2013) Katharine M. Ng et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Identification of an immunomodulating metalloprotease of Pseudomonas aeruginosa (IMPa)

(2012) Bart W. Bardoel et al.   CELLULAR MICROBIOLOGY

Insights into the recognition of the human glycome by microbial carbohydrate-binding modules

(2012) Elizabeth Ficko-Blean et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori

(2012) Yannick Rossez et al.   GLYCOBIOLOGY

Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

An engineered eukaryotic protein glycosylation pathway in Escherichia coli

(2012) Juan D Valderrama-Rincon et al.   Nature Chemical Biology

Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes

(2012) J.-H. Hehemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Chitinolytic Machinery of Enterococcus faecalis V583 and High-Resolution Structure of Its Oxidative CBM33 Enzyme

(2011) Gustav Vaaje-Kolstad et al.   JOURNAL OF MOLECULAR BIOLOGY

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes

(2011) T. Lindhout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

(2011) B. D. Muegge et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

(2011) Eric C. Martens et al.   PLOS BIOLOGY

A hierarchical classification of polysaccharide lyases for glycogenomics

(2010) Vincent Lombard et al.   BIOCHEMICAL JOURNAL

Unique Sugar Metabolic Pathways of Bifidobacteria

(2010) Shinya FUSHINOBU   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota

(2010) Jan-Hendrik Hehemann et al.   NATURE

A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation

(2010) Flavio Schwarz et al.   Nature Chemical Biology

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Distribution of In Vitro Fermentation Ability of Lacto-N-Biose I, a Major Building Block of Human Milk Oligosaccharides, in Bifidobacterial Strains

(2009) J.-z. Xiao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Efficient Synthesis of Sugar Oxazolines from UnprotectedN-Acetyl-2-amino Sugars by Using Chloroformamidinium Reagent in Water

(2009) Masato Noguchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Blood groups: the past 50 years

(2009) Geoff Daniels et al.   TRANSFUSION

Modulation of Neutrophil Function by a Secreted Mucinase of Escherichia coli O157∶H7

(2009) Rose L. Szabady et al.   PLoS Pathogens

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

(2008) Eric C. Martens et al.   Cell Host & Microbe

Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner

(2008) Emer P. Reeves et al.   GASTROENTEROLOGY

Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis

(2008) Maria Allhorn et al.   PLoS One

Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB

(2008) E. Ficko-Blean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry