Mucin utilization by gut microbiota: recent advances on characterization of key enzymes

Carbohydrate-active enzymes (CAZymes) in the gut microbiome

(2022) Jacob F. Wardman et al.   NATURE REVIEWS MICROBIOLOGY

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota

(2022) Ana S Luis et al.   Nature Chemical Biology

IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning

(2021) Elena Layunta et al.   Cell Reports

A single sulfatase is required to access colonic mucin by a gut bacterium

(2021) Ana S. Luis et al.   NATURE

The carbohydrate-active enzyme database: functions and literature

(2021) Elodie Drula et al.   NUCLEIC ACIDS RESEARCH

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

(2021) Haiyang Wu et al.   PLOS BIOLOGY

The Catalytic Acid-Base in GH109 Resides in a Conserved GGHGG Loop and Allows for Comparable α-Retaining and β-Inverting Activity in an N-Acetylgalactosaminidase from Akkermansia muciniphila

(2020) David Teze et al.   ACS Catalysis

Mucins and the Microbiome

(2020) Gunnar C. Hansson   Annual Review of Biochemistry

Fucosidases from the human gut symbiont Ruminococcus gnavus

(2020) Haiyang Wu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of three novel β-galactosidases from Akkermansia muciniphila involved in mucin degradation

(2020) Konrad Kosciow et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice

(2020) Gregory P. Donaldson et al.   Nature Microbiology

Screening and characterization of an α-L-fucosidase from Bacteroides fragilis NCTC9343 for synthesis of fucosyl-N-acetylglucosamine disaccharides

(2020) Peng Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

(2020) Lucy I. Crouch et al.   Nature Communications

Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

(2020) Michael Jakob Pichler et al.   Nature Communications

Structural and biochemical analyses of β-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila involved in mucin degradation

(2020) Wenjuan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystallographic evidence for substrate-assisted catalysis of β-N-acetylhexosaminidas from Akkermansia muciniphila

(2019) Xi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

(2019) Justina Briliūtė et al.   Nature Microbiology

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood

(2019) Peter Rahfeld et al.   Nature Microbiology

Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a β-N-acetylhexosaminidase in Akkermansia muciniphila

(2019) Xi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action

(2019) Pedro Bule et al.   Nature Communications

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

(2019) Andrew Bell et al.   Nature Microbiology

Toward universal donor blood: Enzymatic conversion of A and B to O type

(2019) Peter Rahfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

Cloning, purification and biochemical characterisation of a GH35 beta-1,3/beta-1,6-galactosidase from the mucin-degrading gut bacterium Akkermansia muciniphila

(2018) Bi-Shan Guo et al.   GLYCOCONJUGATE JOURNAL

Functional metagenomics identifies an exosialidase with an inverting catalytic mechanism that defines a new glycoside hydrolase family (GH156)

(2018) Léa Chuzel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors

(2017) Mayo Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sialateO-acetylesterase EstA from gutBacteroidetesspecies enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans

(2017) Lloyd S. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialidases from gut bacteria: a mini-review

(2016) N. Juge et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Matching the Diversity of Sulfated Biomolecules: Creation of a Classification Database for Sulfatases Reflecting Their Substrate Specificity

(2016) Tristan Barbeyron et al.   PLoS One

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles

(2015) Christina A. Hickey et al.   Cell Host & Microbe

A Second β-Hexosaminidase Encoded in theStreptococcus pneumoniaeGenome Provides an Expanded Biochemical Ability to Degrade Host Glycans

(2015) Melissa Robb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation

(2015) Louise E. Tailford et al.   Nature Communications

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

(2014) Felix Sommer et al.   PLoS One

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution

(2013) Jessica M. Holmén Larsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Identifying the Catalytic Acid/Base in GH29 α-l-Fucosidase Subfamilies

(2013) F. Aidha Shaikh et al.   BIOCHEMISTRY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

(2013) Katharine M. Ng et al.   NATURE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in the Substrate Specificities and Active-Site Structures of Two α-L-Fucosidases (Glycoside Hydrolase Family 29) fromBacteroides thetaiotaomicron

(2012) Haruko SAKURAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Comparative structural analysis of the glycosylation of salivary and buccal cell proteins: innate protection against infection by Candida albicans

(2012) Arun V Everest-Dass et al.   GLYCOBIOLOGY

Fucose sensing regulates bacterial intestinal colonization

(2012) Alline R. Pacheco et al.   NATURE

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

α-N-Acetylgalactosaminidase from Infant-associated Bifidobacteria Belonging to Novel Glycoside Hydrolase Family 129 Is Implicated in Alternative Mucin Degradation Pathway

(2011) Masashi Kiyohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Enhanced Detection of Sialylated and Sulfated Glycans with Negative Ion Mode Nanoliquid Chromatography/Mass Spectrometry at High pH

(2010) Kristina A. Thomsson et al.   ANALYTICAL CHEMISTRY

A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn

(2009) Jessica M Holmén Larsson et al.   GLYCOBIOLOGY

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

(2008) Eric C. Martens et al.   Cell Host & Microbe

Novel endo- -N-acetylgalactosaminidases with broader substrate specificity

(2008) D. Koutsioulis et al.   GLYCOBIOLOGY

Identification of a GH110 Subfamily of α1,3-Galactosidases

(2008) Qiyong P. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA