Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

(2021) Elisabeth E. L. Nyström et al.   SCIENCE

Assembly Mechanism of Mucin and von Willebrand Factor Polymers

(2020) Gabriel Javitt et al.   CELL

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

(2019) Génesis Vega et al.   Frontiers in Physiology

The Muc2 mucin coats murine Paneth cell granules and facilitates their content release and dispersion

(2018) Martin Stahl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection

(2018) Sid Ahmed Labed et al.   IMMUNITY

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

(2018) Sergio Trillo-Muyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

The elusive case of human intraepithelial T cells in gut homeostasis and inflammation

(2018) Lisanne Lutter et al.   Nature Reviews Gastroenterology & Hepatology

Study of mucin turnover in the small intestine by in vivo labeling

(2018) Hannah Schneider et al.   Scientific Reports

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

(2018) Moshe Biton et al.   CELL

Syntaxin 3, but not Syntaxin 4, is required for mast cell regulated exocytosis, where it plays a primary role mediating compound exocytosis

(2018) Elizabeth Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

(2017) Bryan B. Yoo et al.   IMMUNITY

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity

(2016) Shobhit Dhawan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

(2016) T. Sujino et al.   SCIENCE

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium

(2015) Leon P. McLean et al.   INFLAMMATORY BOWEL DISEASES

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

(2015) Panagiotis S. Kabouridis et al.   NEURON

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice

(2014) Toshio Takahashi et al.   FEBS Journal

Carbachol-induced colonic mucus formation requires transport via NKCC1, K+ channels and CFTR

(2014) Jenny K. Gustafsson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Microbial-induced meprin   cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

(2014) A. Schutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

(2013) Anna Ermund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms

(2013) Ling-Gang Wu et al.   Annual Review of Physiology

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily

(2012) Jean-Pierre Changeux   JOURNAL OF BIOLOGICAL CHEMISTRY

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

(2012) Jenny K. Gustafsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomic Study of the Mucin Granulae in an Intestinal Goblet Cell Model

(2012) Ana M. Rodríguez-Piñeiro et al.   JOURNAL OF PROTEOME RESEARCH

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants

(2011) Jenny K. Gustafsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Quality control and preprocessing of metagenomic datasets

(2011) R. Schmieder et al.   BIOINFORMATICS

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine

(2010) Robert L. Jakab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ion transport in the small intestine

(2010) Jayashree Venkatasubramanian et al.   CURRENT OPINION IN GASTROENTEROLOGY

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator–dependent bicarbonate secretion

(2009) Mary Abigail S. Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

STIM and Orai: the long-awaited constituents of store-operated calcium entry

(2009) Péter Várnai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Secreted enteric antimicrobial activity localises to the mucus surface layer

(2008) U Meyer-Hoffert et al.   GUT

Genetic Background and the Dilemma of Translating Mouse Studies to Humans

(2008) Juan Rivera et al.   IMMUNITY

Munc13-2−/−baseline secretion defect reveals source of oligomeric mucins in mouse airways

(2008) Yunxiang Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

(2008) Paul M Quinton   LANCET