Small molecules from the human microbiota

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Engineering the plant rhizosphere

(2015) Yanxia Zhang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Cancer and the microbiota

(2015) W. S. Garrett   SCIENCE

Biosynthesis and Export of Bacterial Lipopolysaccharides

(2014) Chris Whitfield et al.   Annual Review of Biochemistry

Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease

(2014) Fred S Sarfo et al.   BMC INFECTIOUS DISEASES

Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains

(2014) Lenka Micenková et al.   BMC MICROBIOLOGY

Functional identification of a galactosyltransferase critical to Bacteroides fragilis Capsular Polysaccharide A biosynthesis

(2014) Jerry M. Troutman et al.   CARBOHYDRATE RESEARCH

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Mycolic Acids: Structures, Biosynthesis, and Beyond

(2014) Hedia Marrakchi et al.   CHEMISTRY & BIOLOGY

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida albicans

(2014) Helena Sztajer et al.   ISME Journal

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive oligosaccharide natural products

(2014) Emilianne K. McCranie et al.   NATURAL PRODUCT REPORTS

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Genotoxic Klebsiella pneumoniae in Taiwan

(2014) Yi-Chyi Lai et al.   PLoS One

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

(2014) G. Schneditz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

(2014) N. Ziemert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying Gut Microbe-Host Phenotype Relationships Using Combinatorial Communities in Gnotobiotic Mice

(2014) J. J. Faith et al.   Science Translational Medicine

Biosynthetic Assembly of the Bacteroides fragilis Capsular Polysaccharide A Precursor Bactoprenyl Diphosphate-Linked Acetamido-4-amino-6-deoxygalactopyranose

(2013) Anahita Z. Mostafavi et al.   BIOCHEMISTRY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

(2013) Xiaoying Bian et al.   CHEMBIOCHEM

A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice

(2013) A Marcobal et al.   ISME Journal

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

(2013) Anne-Caroline Chany et al.   NATURAL PRODUCT REPORTS

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

(2013) Morgan G I Langille et al.   NATURE BIOTECHNOLOGY

A conserved human T cell population targets mycobacterial antigens presented by CD1b

(2013) Ildiko Van Rhijn et al.   NATURE IMMUNOLOGY

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Enhanced Production, Purification, Characterization and Mechanism of Action of Salivaricin 9 Lantibiotic Produced by Streptococcus salivarius NU10

(2013) Abdelahhad Barbour et al.   PLoS One

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

(2013) Laura C. Wieland Brown et al.   PLOS BIOLOGY

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

(2012) K. P. Patel et al.   Clinical Journal of the American Society of Nephrology

Linaclotide

(2012) Vanessa McWilliams et al.   DRUGS

Mycobacterium tuberculosis Lacking All Mycolic Acid Cyclopropanation Is Viable but Highly Attenuated and Hyperinflammatory in Mice

(2012) Daniel Barkan et al.   INFECTION AND IMMUNITY

Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection

(2012) Matthew J. LaMarche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Identification and Characterization of Microcin S, a New Antibacterial Peptide Produced by Probiotic Escherichia coli G3/10

(2012) Anke Zschüttig et al.   PLoS One

Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca

(2012) K. Temme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Therapeutic Modulation of Microbiota-Host Metabolic Interactions

(2012) E. Holmes et al.   Science Translational Medicine

Temporal Dynamics of the Human Vaginal Microbiota

(2012) P. Gajer et al.   Science Translational Medicine

The Rules of Engagement in the Legume-Rhizobial Symbiosis

(2011) Giles E.D. Oldroyd et al.   Annual Review of Genetics

Ruminococcin C, a new anti-Clostridium perfringens bacteriocin produced in the gut by the commensal bacterium Ruminococcus gnavus E1

(2011) E.H. Crost et al.   BIOCHIMIE

Eating For Two: How Metabolism Establishes Interspecies Interactions in the Gut

(2011) Michael A. Fischbach et al.   Cell Host & Microbe

Bacterial symbionts and natural products

(2011) Jason M. Crawford et al.   CHEMICAL COMMUNICATIONS

Biosynthesis of the Antimicrobial Peptide Epilancin 15X and Its N-Terminal Lactate

(2011) Juan E. Velásquez et al.   CHEMISTRY & BIOLOGY

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates

(2011) Joel O Melby et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans

(2011) Auke Johan van Heel et al.   Expert Opinion on Drug Metabolism & Toxicology

Characterization and distribution of the gene cluster encoding RumC, an anti-Clostridium perfringens bacteriocin produced in the gut

(2011) Ange Pujol et al.   FEMS MICROBIOLOGY ECOLOGY

Colonic Contribution to Uremic Solutes

(2011) P. A. Aronov et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Streptolysin S-like virulence factors: the continuing sagA

(2011) Evelyn M. Molloy et al.   NATURE REVIEWS MICROBIOLOGY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Fungal biofilm inhibitors from a human oral microbiome-derived bacterium

(2011) Xiaoru Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemistry of mycolactones, the causative toxins of Buruli ulcer

(2011) Y. Kishi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis

(2011) M. S. Donia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Genomic Island TnSmu2 of Streptococcus mutans Harbors a Nonribosomal Peptide Synthetase-Polyketide Synthase Gene Cluster Responsible for the Biosynthesis of Pigments Involved in Oxygen and H2O2 Tolerance

(2010) C. Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteriocin synthesis in uropathogenic and commensal Escherichia coli: colicin E1 is a potential virulence factor

(2010) David Šmajs et al.   BMC MICROBIOLOGY

A Family of Pyrazinone Natural Products from a Conserved Nonribosomal Peptide Synthetase in Staphylococcus aureus

(2010) Michael Zimmermann et al.   CHEMISTRY & BIOLOGY

Clostridiolysin S, a Post-translationally Modified Biotoxin fromClostridium botulinum

(2010) David J. Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral multispecies biofilm development and the key role of cell–cell distance

(2010) Paul E. Kolenbrander et al.   NATURE REVIEWS MICROBIOLOGY

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

(2010) P. Matthew Joyner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aureusimines in Staphylococcus aureus Are Not Involved in Virulence

(2010) Fei Sun et al.   PLoS One

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus Nonribosomal Peptide Secondary Metabolites Regulate Virulence

(2010) M. A. Wyatt et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

(2009) Jason M. Ridlon et al.   ANAEROBE

Mycolic Acids Constitute a Scaffold for Mycobacterial Lipid Antigens Stimulating CD1-Restricted T Cells

(2009) Emilie Layre et al.   CHEMISTRY & BIOLOGY

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

(2009) J. Putze et al.   INFECTION AND IMMUNITY

Production of the Bsa Lantibiotic by Community-Acquired Staphylococcus aureus Strains

(2009) K. M. Daly et al.   JOURNAL OF BACTERIOLOGY

Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S

(2009) Douglas A. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role ofrsbUand Staphyloxanthin in Phagocytosis and Intracellular Growth ofStaphylococcus aureusin Human Macrophages and Endothelial Cells

(2009) Aurélie C. Olivier et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomics and Evolution of Heritable Bacterial Symbionts

(2008) Nancy A. Moran et al.   Annual Review of Genetics

Maturation of anEscherichiacoliRibosomal Peptide Antibiotic by ATP-Consuming N−P Bond Formation in Microcin C7

(2008) Rebecca F. Roush et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

(2008) Hui Hong et al.   NATURAL PRODUCT REPORTS

Metabolites from symbiotic bacteria

(2008) Jörn Piel   NATURAL PRODUCT REPORTS

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Discovery of a widely distributed toxin biosynthetic gene cluster

(2008) S. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

(2008) Dee N. Dao et al.   PLoS Pathogens

Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes

(2008) Paul D. Cotter et al.   PLoS Pathogens