A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation

Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

(2023) Arno R. Bourgonje et al.   Redox Biology

Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process

(2022) Antero Salminen   AGEING RESEARCH REVIEWS

NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

(2022) Sun Mi Hong et al.   Redox Biology

The metabolic nature of inflammatory bowel diseases

(2022) Timon E. Adolph et al.   Nature Reviews Gastroenterology & Hepatology

NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures

(2022) Nai-Yun Hsu et al.   GUT

Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases

(2022) Chloé Michaudel et al.   GUT

Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis

(2021) Shengchao Zhang et al.   Stem Cell Research & Therapy

Comparative Efficacy for Infliximab Vs Vedolizumab in Biologic Naive Ulcerative Colitis

(2021) Neeraj Narula et al.   Clinical Gastroenterology and Hepatology

The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

(2021) Niklas Joisten et al.   TRENDS IN MOLECULAR MEDICINE

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

(2021) Cristina C. Clement et al.   Nature Communications

Recent advances in clinical trials targeting the kynurenine pathway

(2021) Ananda Staats Pires et al.   PHARMACOLOGY & THERAPEUTICS

The Dual Role of Reactive Oxygen Species-Generating Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Gastrointestinal Inflammation and Therapeutic Perspectives

(2020) Pham My-Chan Dang et al.   ANTIOXIDANTS & REDOX SIGNALING

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

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The four epidemiological stages in the global evolution of inflammatory bowel disease

(2020) Gilaad G. Kaplan et al.   Nature Reviews Gastroenterology & Hepatology

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

(2018) M Anthony Sofia et al.   INFLAMMATORY BOWEL DISEASES

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells

(2018) Camille Martin-Gallausiaux et al.   Frontiers in Immunology

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

NAD metabolism fuels human and mouse intestinal inflammation

(2017) Romana R Gerner et al.   GUT

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease

(2017) Maaike Vancamelbeke et al.   INFLAMMATORY BOWEL DISEASES

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

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NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

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Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

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Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors

(2016) Jason R. Smith et al.   DRUG DISCOVERY TODAY

The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases

(2016) Jamie L. Harden et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

(2016) Damian J Mole et al.   NATURE MEDICINE

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

(2015) Amy B. Dounay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intestinal CD103+CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells

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Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Structure and mechanism of kynureninase

(2013) Robert S. Phillips   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

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Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations

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Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

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Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

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Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data

(2009) Jrgen Olsen et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide gene expression analysis of mucosal colonic biopsies and isolated colonocytes suggests a continuous inflammatory state in the lamina propria of patients with quiescent ulcerative colitis

(2009) Jacob Tveiten Bjerrum et al.   INFLAMMATORY BOWEL DISEASES