NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures

MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

(2021) Ningbo Wu et al.   NATURE

374 INFLAMED ULCERATIVE COLITIS REGIONS ASSOCIATED TO MRGPRX2-MEDIATED MAST CELL DEGRANULATION AND CELL ACTIVATION MODULES, DEFINING A NEW THERAPEUTIC TARGET

(2021) Ling-shiang F. Chuang et al.   GASTROENTEROLOGY

A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease

(2021) Shikha Nayar et al.   NATURE

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Cell fate specification and differentiation in the adult mammalian intestine

(2020) Joep Beumer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease

(2020) Rasa Elmentaite et al.   DEVELOPMENTAL CELL

Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort

(2020) Kyle Gettler et al.   GASTROENTEROLOGY

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

M Cells: Intelligent Engineering of Mucosal Immune Surveillance

(2019) Andrea Dillon et al.   Frontiers in Immunology

Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

(2019) Jerome C. Martin et al.   CELL

Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects

(2019) Gabriella Aviello et al.   Mucosal Immunology

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn’s Disease

(2018) Lee A. Denson et al.   GASTROENTEROLOGY

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

(2017) T Schwerd et al.   Mucosal Immunology

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Current and emerging therapeutic targets for IBD

(2017) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Induction of Colonic M Cells during Intestinal Inflammation

(2016) Kaila M. Bennett et al.   AMERICAN JOURNAL OF PATHOLOGY

TNF-α augments RANKL-dependent intestinal M cell differentiation in enteroid cultures

(2016) Megan B. Wood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

(2016) G Aviello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

(2016) Isabella Dotti et al.   GUT

Genetic Risk for Inflammatory Bowel Disease Is a Determinant of Crohnʼs Disease Development in Chronic Granulomatous Disease

(2016) Chengrui Huang et al.   INFLAMMATORY BOWEL DISEASES

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

Reg4+deep crypt secretory cells function as epithelial niche for Lgr5+stem cells in colon

(2016) Nobuo Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biologic agents for IBD: practical insights

(2015) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

Histological evaluation in ulcerative colitis

(2014) T. C. DeRoche et al.   Gastroenterology Report

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Many Inflammatory Bowel Disease Risk Loci Include Regions That Regulate Gene Expression in Immune Cells and the Intestinal Epithelium

(2013) Michal Mokry et al.   GASTROENTEROLOGY

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured "Miniguts"

(2012) W. de Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

(2010) Nicolas Coant et al.   MOLECULAR AND CELLULAR BIOLOGY

DNMT1 maintains progenitor function in self-renewing somatic tissue

(2010) George L. Sen et al.   NATURE

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

(2009) J. D. Matute et al.   BLOOD

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

(2009) Koji Hase et al.   NATURE

Clinical implications of mucosal healing for the management of IBD

(2009) Guillaume Pineton de Chambrun et al.   Nature Reviews Gastroenterology & Hepatology

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

(2008) Seung-Nam Jung et al.   CARCINOGENESIS