Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

Human serum albumin-based probes for molecular targeting of macrophage scavenger receptors

(2019) Mona Ahmed et al.   International Journal of Nanomedicine

Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study

(2019) Mengyu Li et al.   Scientific Reports

Kynurenic acid attenuates pro-inflammatory reactions in lipopolysaccharide-stimulated endothelial cells through the PPARδ/HO-1-dependent pathway

(2019) Taeseung Lee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr−/− mice

(2019) Martin Berg et al.   CARDIOVASCULAR RESEARCH

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

(2018) Leandro Z. Agudelo et al.   Cell Metabolism

Lipid-driven immunometabolic responses in atherosclerosis

(2018) Anton Gisterå et al.   CURRENT OPINION IN LIPIDOLOGY

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice

(2018) José Tuñón et al.   European Journal of Preventive Cardiology

Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions

(2018) Elisa Wirthgen et al.   Frontiers in Immunology

Aryl Hydrocarbon Receptor Promotes IL-10 Expression in Inflammatory Macrophages Through Src-STAT3 Signaling Pathway

(2018) Junyu Zhu et al.   Frontiers in Immunology

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors

(2017) Francesco Fazio et al.   NEUROPHARMACOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

(2017) Juyong Brian Kim et al.   PLoS Genetics

The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis

(2017) Roland Baumgartner et al.   CYTOKINE

The effect of kynurenic acid on the synthesis of selected cytokines by murine splenocytes – in vitro and ex vivo studies

(2016) Joanna Małaczewska et al.   Central European Journal of Immunology

Atherosclerosis and aortic aneurysm - is inflammation a common denominator?

(2016) Iuliia O. Peshkova et al.   FEBS Journal

Characterization of the Kynurenine Pathway in CD8+ Human Primary Monocyte-Derived Dendritic Cells

(2016) Nady Braidy et al.   NEUROTOXICITY RESEARCH

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity

(2015) J.J. Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe−/− mice

(2015) Konstantinos A. Polyzos et al.   CARDIOVASCULAR RESEARCH

Role of indoleamine 2,3-dioxygenase in health and disease

(2015) Amanda W.S. Yeung et al.   CLINICAL SCIENCE

Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia

(2015) Yi-Hsuan Lee et al.   GLIA

Kynurenines as predictors of acute coronary events in the Hordaland Health Study

(2015) Simone J.P.M. Eussen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations

(2015) Zsuzsanna Bohár et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene expression signatures, pathways and networks in carotid atherosclerosis

(2015) L. Perisic et al.   JOURNAL OF INTERNAL MEDICINE

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation

(2015) Jennifer E. McCallum et al.   JOURNAL OF VASCULAR RESEARCH

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

(2015) Marie Favennec et al.   Obesity

Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development

(2015) Jennifer E. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

T Cell-based Therapies for Atherosclerosis

(2013) Daniel Ketelhuth et al.   CURRENT PHARMACEUTICAL DESIGN

Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography

(2013) Eva Ringdal Pedersen et al.   EUROPEAN HEART JOURNAL

Neopterin and kynurenine–tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study

(2013) Gerhard Sulo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response

(2013) Christoph F. A. Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine

(2013) Anne-Sofie Johansson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice

(2012) Lei Zhang et al.   EUROPEAN HEART JOURNAL

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

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(2012) Lasse Folkersen et al.   MOLECULAR MEDICINE

Kynurenic acid attenuates multiorgan dysfunction in rats after heatstroke

(2011) Yi-chang Hsieh et al.   ACTA PHARMACOLOGICA SINICA

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

(2011) Linnéa Asp et al.   Journal of Inflammation-London

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

(2011) Zoltán Tiszlavicz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

(2011) Juliana Croitoru-Lamoury et al.   PLoS One

Kynurenines, neurodegeneration and Alzheimer’s disease

(2010) Zsigmond Tamas Kincses et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and  -Arrestin2 with Antinociceptive Activity

(2010) P. Zhao et al.   MOLECULAR PHARMACOLOGY

The Role of Tryptophan Catabolism along the Kynurenine Pathway in Acute Ischemic Stroke

(2010) Raf Brouns et al.   NEUROCHEMICAL RESEARCH

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study

(2009) Petri Niinisalo et al.   ANNALS OF MEDICINE

Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions

(2009) Marita C. Barth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2',4'-Trimethoxyflavone

(2009) I. A. Murray et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock

(2009) H. Sekine et al.   MOLECULAR AND CELLULAR BIOLOGY

Indoleamine 2,3‐dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study

(2008) P. Niinisalo et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION