ROS in gastrointestinal inflammation: Rescue Or Sabotage?

Pharmacological Potential of NOX2 Agonists in Inflammatory Conditions

(2015) Malin Hultqvist et al.   ANTIOXIDANTS & REDOX SIGNALING

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes

(2015) Kyung-Ah Lee et al.   Cell Host & Microbe

Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases

(2015) Mehdi Torki et al.   DIGESTIVE DISEASES AND SCIENCES

CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells

(2015) Rowan Flynn et al.   EXPERIMENTAL HEMATOLOGY

Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

(2015) Helmut Grasberger et al.   GASTROENTEROLOGY

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis

(2015) Nicholas A. Manieri et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular and Molecular Mediators of Intestinal Fibrosis

(2015) Ian C. Lawrance et al.   Journal of Crohns & Colitis

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells

(2015) M. R. Hepworth et al.   SCIENCE

Genetic disorders coupled to ROS deficiency

(2015) Sharon O’Neill et al.   Redox Biology

Chronic granulomatous disease mimicking early-onset Crohn’s disease with cutaneous manifestations

(2014) Maria Barbato et al.   BMC Pediatrics

The monocyte-macrophage axis in the intestine

(2014) Calum C. Bain et al.   CELLULAR IMMUNOLOGY

C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

(2014) Suhong Xu et al.   DEVELOPMENTAL CELL

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of mitochondria-derived reactive oxygen species in the pathogenesis of non-steroidal anti-inflammatory drug-induced small intestinal injury

(2014) O. Handa et al.   FREE RADICAL RESEARCH

Variants in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Complex Components Determine Susceptibility to Very Early Onset Inflammatory Bowel Disease

(2014) Sandeep S. Dhillon et al.   GASTROENTEROLOGY

The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease

(2014) Holm H. Uhlig et al.   GASTROENTEROLOGY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid

(2014) Tammie S. MacFie et al.   INFLAMMATORY BOWEL DISEASES

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

(2014) Yael Haberman et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium

(2014) F Sommer et al.   Mucosal Immunology

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deficient Production of Reactive Oxygen Species Leads to Severe Chronic DSS-Induced Colitis in Ncf1/p47phox-Mutant Mice

(2014) Tiago Rodrigues-Sousa et al.   PLoS One

Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

(2014) Xavier Tréton et al.   PLoS One

PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine

(2014) Elena Bellafante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incidence and Paris Classification of Pediatric Inflammatory Bowel Disease

(2014) Katalin Eszter Müller et al.   Gastroenterology Research and Practice

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome

(2014) Deborah D. Crane et al.   Frontiers in Microbiology

Higher Activity of the Inducible Nitric Oxide Synthase Contributes to Very Early Onset Inflammatory Bowel Disease

(2014) Sandeep S Dhillon et al.   Clinical and Translational Gastroenterology

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

(2013) Fiorella Biasi et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of NADPH Oxidases in Liver Fibrosis

(2013) Yong-Han Paik et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

(2013) Amarjargal Dashdorj et al.   BMC Medicine

The Other Face of ROS: a Driver of Stem Cell Expansion in Colorectal Cancer

(2013) Pier Giuseppe Pelicci et al.   Cell Stem Cell

Diagnosis and Treatment of Gastrointestinal Disorders in Patients With Primary Immunodeficiency

(2013) Shradha Agarwal et al.   Clinical Gastroenterology and Hepatology

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

Symbiotic lactobacilli stimulate gut epithelial proliferationviaNox-mediated generation of reactive oxygen species

(2013) Rheinallt M Jones et al.   EMBO JOURNAL

Reactive oxygen species and the free radical theory of aging

(2013) Stefan I. Liochev   FREE RADICAL BIOLOGY AND MEDICINE

Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2

(2013) Robert S. Esworthy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of natural polyphenols (Pycnogenol) on oxidative stress markers in children suffering from Crohn's disease – a pilot study

(2013) M. Koláček et al.   FREE RADICAL RESEARCH

Dual Oxidases Control Release of Hydrogen Peroxide by the Gastric Epithelium to Prevent Helicobacter felis Infection and Inflammation in Mice

(2013) Helmut Grasberger et al.   GASTROENTEROLOGY

Antioxidant Properties of Mesalamine in Colitis Inhibit Phosphoinositide 3-Kinase Signaling in Progenitor Cells

(2013) Elizabeth Managlia et al.   INFLAMMATORY BOWEL DISEASES

Infliximab Reduces Hospitalizations and Surgery Interventions in Patients With Inflammatory Bowel Disease

(2013) João Costa et al.   INFLAMMATORY BOWEL DISEASES

Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study

(2013) Tayfun Güngör et al.   LANCET

Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps

(2013) Tina Kirchner et al.   MEDIATORS OF INFLAMMATION

The role of pattern recognition receptors in intestinal inflammation

(2013) M Fukata et al.   Mucosal Immunology

Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1

(2013) A Alam et al.   Mucosal Immunology

Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration

(2013) Nick R. Love et al.   NATURE CELL BIOLOGY

The role of transcription-independent damage signals in the initiation of epithelial wound healing

(2013) João V. Cordeiro et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells

(2013) Jesper A. B. Strickertsson et al.   PLoS One

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

(2013) M. A. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut

(2013) S. E. Winter et al.   SCIENCE

The redox interplay between nitrite and nitric oxide: From the gut to the brain

(2013) Cassilda Pereira et al.   Redox Biology

Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice

(2012) Masashi Yasuda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mucosal Reactive Oxygen Species Decrease Virulence by Disrupting Campylobacter jejuni Phosphotyrosine Signaling

(2012) Nicolae Corcionivoschi et al.   Cell Host & Microbe

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling

(2012) Seheli Kajla et al.   FASEB JOURNAL

Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema

(2012) Manuella Lanzetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

(2012) Ryo Kodama et al.   GENES TO CELLS

Chronic Granulomatous Disease

(2012) Steven M. Holland   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Intestinal myofibroblasts produce nitric oxide in response to combinatorial cytokine stimulation

(2012) Jianfeng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

(2012) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management

(2012) Axel Dignass et al.   Journal of Crohns & Colitis

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation

(2012) K. L. Conway et al.   JOURNAL OF IMMUNOLOGY

Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid

(2012) Helmut Grasberger et al.   MOLECULAR ENDOCRINOLOGY

TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1

(2012) D. Peter O'Leary et al.   PLoS One

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

(2012) Weiqin Lu et al.   PLOS BIOLOGY

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Guidelines for the management of inflammatory bowel disease in adults

(2011) C. Mowat et al.   GUT

Gp91phox contributes to the development of experimental inflammatory bowel disease

(2011) Shisan Bao et al.   IMMUNOLOGY AND CELL BIOLOGY

Reciprocal Regulation of The Survival and Apoptosis of Th17 and Th1 Cells in The Colon

(2011) Irina V. Ustyugova et al.   INFLAMMATORY BOWEL DISEASES

Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

(2011) Yusuke Kurihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective role of uncoupling protein-2 against dextran sodium sulfate-induced colitis

(2011) Hongjie Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Clinical trial: vitamin D3 treatment in Crohn’s disease - a randomized double-blind placebo-controlled study

(2010) S. P. Jørgensen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects

(2010) John J. Tanner et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

NF-κB in the regulation of epithelial homeostasis and inflammation

(2010) Andy Wullaert et al.   CELL RESEARCH

RETRACTED: REDOX regulation of IL-13 signaling in intestinal epithelial cells: Usage of alternate pathways mediates distinct gene expression patterns

(2010) Debasmita Mandal et al.   CELLULAR SIGNALLING

Complications of Tumor Necrosis Factor–α Blockade in Chronic Granulomatous Disease–Related Colitis

(2010) Gulbu Uzel et al.   CLINICAL INFECTIOUS DISEASES

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

(2010) L. E. Wroblewski et al.   CLINICAL MICROBIOLOGY REVIEWS

Helicobacter pylori: a ROS-inducing bacterial species in the stomach

(2010) Osamu Handa et al.   INFLAMMATION RESEARCH

Helicobacter pylori-Induced Th17 Responses Modulate Th1 Cell Responses, Benefit Bacterial Growth, and Contribute to Pathology in Mice

(2010) Y. Shi et al.   JOURNAL OF IMMUNOLOGY

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

(2010) Nicolas Coant et al.   MOLECULAR AND CELLULAR BIOLOGY

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Gene Therapy of Chronic Granulomatous Disease: The Engraftment Dilemma

(2010) Manuel Grez et al.   MOLECULAR THERAPY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Chronic granulomatous disease

(2010) Alexander J. Towbin et al.   PEDIATRIC RADIOLOGY

Role of Innate Immunity in Helicobacter pylori-Induced Gastric Malignancy

(2010) Richard M. Peek et al.   PHYSIOLOGICAL REVIEWS

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine

(2010) Diana Couto et al.   REDOX REPORT

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Potentiation of Epithelial Innate Host Responses by Intercellular Communication

(2010) Tamas Dolowschiak et al.   PLoS Pathogens

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

(2009) J. D. Matute et al.   BLOOD

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

(2009) Agnes Juhasz et al.   FREE RADICAL RESEARCH

Association of UCP2 −866 G/A polymorphism with chronic inflammatory diseases

(2009) X Yu et al.   GENES AND IMMUNITY

Perturbation of the Small Intestine Microbial Ecology by Streptomycin Alters Pathology in a Salmonella enterica Serovar Typhimurium Murine Model of Infection

(2009) C. D. Garner et al.   INFECTION AND IMMUNITY

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

(2009) S. Lipinski et al.   JOURNAL OF CELL SCIENCE

Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon

(2009) Mai Kamizato et al.   JOURNAL OF GASTROENTEROLOGY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Regulation of cell proliferation by NADPH oxidase-mediated signaling: Potential roles in tissue repair, regenerative medicine and tissue engineering

(2009) Elsa C. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound healing essentials: Let there be oxygen

(2009) Chandan K. Sen   WOUND REPAIR AND REGENERATION

Inflammatory Bowel Disease in CGD Reproduces the Clinicopathological Features of Crohn's Disease

(2008) Daniel J B Marks et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation

(2008) L Shen et al.   CELL DEATH AND DIFFERENTIATION

Tumor necrosis factor α activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells

(2008) Yuki Kuwano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Helicobacter pylori Induces an Antimicrobial Response in Rhesus Macaques in a cag Pathogenicity Island-Dependent Manner

(2008) Michael J. Hornsby et al.   GASTROENTEROLOGY

Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort

(2008) R L Roberts et al.   GENES AND IMMUNITY

Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras

(2008) Eunice Laurent et al.   INTERNATIONAL JOURNAL OF CANCER

Mutational Analysis Reveals Distinct Features of the Nox4-p22phoxComplex

(2008) Katharina von Löhneysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study

(2008) Luis G Guijarro et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY

Exacerbating Role of γδ T Cells in Chronic Colitis of T-Cell Receptor α Mutant Mice

(2007) Masanobu Nanno et al.   GASTROENTEROLOGY