The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

Dysregulation of Kynurenine Pathway and Potential Dynamic Changes of Kynurenine in Schizophrenia: A Systematic Review and Meta-Analysis

(2021) Bing Cao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis

(2021) Niklas Joisten et al.   Neurology-Neuroimmunology & Neuroinflammation

Kynurenine emerges from the shadows – Current knowledge on its fate and function

(2021) Marta Marszalek-Grabska et al.   PHARMACOLOGY & THERAPEUTICS

Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation

(2020) Giada Mondanelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

(2020) Gayathri Sundaram et al.   Journal of Neuroinflammation

Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis

(2020) Henrique Lemos et al.   Frontiers in Immunology

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

(2020) Ahmed Sadik et al.   CELL

The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

(2020) Wolfgang Marx et al.   MOLECULAR PSYCHIATRY

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

The kynurenine pathway: a finger in every pie

(2019) Jonathan Savitz   MOLECULAR PSYCHIATRY

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

(2019) Leandro Z. Agudelo et al.   Nature Communications

Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease

(2019) Freek J. H. Sorgdrager et al.   JOURNAL OF NEUROCHEMISTRY

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy

(2019) Philipp Zimmer et al.   Frontiers in Oncology

Does kynurenic acid act on nicotinic receptors? An assessment of the evidence

(2019) Trevor W. Stone   JOURNAL OF NEUROCHEMISTRY

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

(2018) Nady Braidy et al.   ANTIOXIDANTS & REDOX SIGNALING

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

(2018) Leandro Z. Agudelo et al.   Cell Metabolism

Kynurenine pathway in depression: A systematic review and meta-analysis

(2018) Kamiyu Ogyu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Kynurenine pathway metabolism and neuroinflammatory disease

(2017) Nady Braidy et al.   Neural Regeneration Research

Kynurenine pathway metabolites and suicidality

(2017) Elena Y. Bryleva et al.   NEUROPHARMACOLOGY

The kynurenine pathway in schizophrenia and bipolar disorder

(2017) Sophie Erhardt et al.   NEUROPHARMACOLOGY

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

(2017) Chai K. Lim et al.   Scientific Reports

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

(2017) Francesco Fazio et al.   Frontiers in Pharmacology

The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis

(2017) Roland Baumgartner et al.   CYTOKINE

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

(2016) Damian J Mole et al.   NATURE MEDICINE

Large Amounts of Picolinic Acid Are Lethal but Small Amounts Increase the Conversion of Tryptophan-Nicotinamide in Rats

(2015) Katsumi SHIBATA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation and cancer-related fatigue: Mechanisms, contributing factors, and treatment implications

(2012) Julienne E. Bower et al.   BRAIN BEHAVIOR AND IMMUNITY

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

(2010) F. J. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH