NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

Macrophages provide a transient muscle stem cell niche via NAMPT secretion

(2021) Dhanushika Ratnayake et al.   NATURE

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

(2021) Mihoko Yoshino et al.   SCIENCE

NAMPT reduction‐induced NAD + insufficiency contributes to the compromised oocyte quality from obese mice

(2021) Hengjie Wang et al.   AGING CELL

Nutritional Aspects in Inflammatory Bowel Diseases

(2020) Paola Balestrieri et al.   Nutrients

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

(2020) Valentina Audrito et al.   Frontiers in Oncology

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

(2019) Xin Zhou et al.   Cell Reports

Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

(2019) Mitsukuni Yoshida et al.   Cell Metabolism

Intestinal Macrophages in Resolving Inflammation

(2019) Ashley M. Hine et al.   JOURNAL OF IMMUNOLOGY

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

(2019) Yi Rang Na et al.   Nature Reviews Gastroenterology & Hepatology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Metabolic programming of macrophage functions and pathogens control

(2019) Sue-jie Koo et al.   Redox Biology

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

(2019) Wei-Chen Yen et al.   Redox Biology

Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence

(2018) Ravirajsinh N. Jadeja et al.   Aging-US

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

(2018) David Bauché et al.   IMMUNITY

NAD metabolism fuels human and mouse intestinal inflammation

(2017) Romana R Gerner et al.   GUT

Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells

(2017) Allison W. Roberts et al.   IMMUNITY

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

(2017) Lauren A Peters et al.   NATURE GENETICS

Colonic macrophage polarization in homeostasis, inflammation, and cancer

(2016) Raymond A. Isidro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammation-driven malnutrition: a new screening tool predicts outcome in Crohn’s disease

(2016) Irene Jansen et al.   BRITISH JOURNAL OF NUTRITION

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

(2016) Chang Sup Lee et al.   IMMUNITY

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

(2016) Bangwei Luo et al.   Nature Communications

Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome

(2016) E. Liana Falcone et al.   Microbiome

SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

(2015) Myeong Jin Yoon et al.   Cell Metabolism

Physiological and pathophysiological roles of NAMPT and NAD metabolism

(2015) Antje Garten et al.   Nature Reviews Endocrinology

NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer

(2015) S M Hong et al.   ONCOGENE

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

Disequilibrium of M1 and M2 Macrophages Correlates with the Development of Experimental Inflammatory Bowel Diseases

(2014) Wei Zhu et al.   IMMUNOLOGICAL INVESTIGATIONS

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

(2009) Erika Koltai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nampt: linking NAD biology, metabolism and cancer

(2008) Antje Garten et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM