LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease

LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq

(2023) Wilson McKerrow et al.   NUCLEIC ACIDS RESEARCH

Phase Separation in cGAS‐STING Signaling: Cytosolic DNA Sensing and Regulatory Functions

(2023) Caixia Liu et al.   CHEMBIOCHEM

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

(2023) Sabateeshan Mathavarajah et al.   NUCLEIC ACIDS RESEARCH

Condensation of LINE-1 is critical for retrotransposition

(2023) Srinjoy Sil et al.   eLife

Retrotransposons as a Source of DNA Damage in Neurodegeneration

(2022) Eugenie Peze-Heidsieck et al.   Frontiers in Aging Neuroscience

The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity

(2022) Nanxin Liu et al.   Frontiers in Immunology

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint

(2022) Wilson McKerrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5′-UTR

(2022) Jiaxiu Yan et al.   Mobile DNA

Activation of cGAS‐STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune‐mediated necrotizing myopathy

(2022) Meichen Zhou et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

(2022) Tina Schumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Replicative Senescence-Associated LINE1 Methylation and LINE1-Alu Expression Levels in Human Endothelial Cells

(2022) Deborah Ramini et al.   Cells

ER-directed TREX1 limits cGAS activation at micronuclei

(2021) Lisa Mohr et al.   MOLECULAR CELL

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

(2021) Wen Zhou et al.   MOLECULAR CELL

DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response

(2021) Xuan Song et al.   JOURNAL OF NEUROSCIENCE

IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs

(2021) Maya Shemesh et al.   Science Signaling

Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease

(2021) Yuko Kuriyama et al.   Scientific Reports

BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells

(2020) Paolo Mita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids

(2020) Eva Bartok et al.   IMMUNITY

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

(2020) Xuewu Zhang et al.   IMMUNITY

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication

(2019) Diane A. Flasch et al.   CELL

Transposable element activity, genome regulation and human health

(2018) Lu Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition

(2018) Jongsu Choi et al.   NUCLEIC ACIDS RESEARCH

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

LINE-1 protein localization and functional dynamics during the cell cycle

(2018) Paolo Mita et al.   eLife

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation

(2018) Alexandra Herrmann et al.   Mobile DNA

Involvement of Conserved Amino Acids in the C-Terminal Region of LINE-1 ORF2p in Retrotransposition

(2017) Claiborne M. Christian et al.   GENETICS

Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

(2017) Peng Li et al.   NUCLEIC ACIDS RESEARCH

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Involvement of Conserved Amino Acids in the C-Terminal Region of LINE-1 ORF2p in Retrotransposition

(2017) Claiborne M. Christian et al.   GENETICS

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

(2016) Karen J Mackenzie et al.   EMBO JOURNAL

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

(2016) Vladislav Pokatayev et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADAR1 restricts LINE-1 retrotransposition

(2016) Elisa Orecchini et al.   NUCLEIC ACIDS RESEARCH

Roles for retrotransposon insertions in human disease

(2016) Dustin C. Hancks et al.   Mobile DNA

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

(2016) Christelle Brégnard et al.   EBioMedicine

Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity

(2015) Ahmet M. Denli et al.   CELL

LINE-1 in cancer: multifaceted functions and potential clinical implications

(2015) Lu Xiao-Jie et al.   GENETICS IN MEDICINE

Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

(2015) M. R. Garbati et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Crossing the LINE Toward Genomic Instability: LINE-1 Retrotransposition in Cancer

(2015) Jacqueline R. Kemp et al.   Frontiers in Chemistry

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

The MOV10 Helicase Inhibits LINE-1 Mobility

(2013) Xiaoyu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The carboxy-terminal segment of the human LINE-1 ORF2 protein is involved in RNA binding

(2013) Olga Piskareva et al.   FEBS Open Bio

Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses

(2012) Shetal Arjan-Odedra et al.   Retrovirology

Alu and LINE-1 methylation and lung function in the normative ageing study

(2012) Nancy E Lange et al.   BMJ Open

LINE-1 Retrotransposition Activity in Human Genomes

(2010) Christine R. Beck et al.   CELL

A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?

(2010) Georges St. Laurent et al.   MECHANISMS OF AGEING AND DEVELOPMENT

FA core complex moves to chromatin

(2008) P. Rio et al.   BLOOD

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24

(2008) J. M. Kim et al.   BLOOD

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE