Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

(2016) Warrison A. Andrade et al.   Cell Reports

Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA

(2015) Fenghua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I Interferon Controls Propagation of Long Interspersed Element-1

(2015) Qiujing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

(2015) John L. Goodier et al.   PLoS Genetics

SAMHD1 prevents autoimmunity by maintaining genome stability

(2014) Stefanie Kretschmer et al.   ANNALS OF THE RHEUMATIC DISEASES

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition

(2013) Martin S. Taylor et al.   CELL

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination

(2013) Clinton D. Orebaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MOV10 Helicase Inhibits LINE-1 Mobility

(2013) Xiaoyu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation

(2013) S. Pereira-Lopes et al.   JOURNAL OF IMMUNOLOGY

Aicardi–Goutières syndrome: clues from the RNase H2 knock-out mouse

(2013) Björn Rabe   JOURNAL OF MOLECULAR MEDICINE-JMM

A TREX1 mutation causing cerebral vasculopathy in a patient with familial chilblain lupus

(2013) Kazuo Yamashiro et al.   JOURNAL OF NEUROLOGY

Systemic involvement in TREX1-associated familial chilblain lupus

(2013) Claudia Günther et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition

(2013) John L. Goodier et al.   NUCLEIC ACIDS RESEARCH

RNase H2 roles in genome integrity revealed by unlinking its activities

(2013) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

(2013) Ke Zhao et al.   Cell Reports

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

(2012) Bjoern Hiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Requirements for HIV-1 Vif-Mediated APOBEC3G Degradation and RUNX1-Mediated Transcription by Core Binding Factor Beta

(2012) Juan Du et al.   JOURNAL OF VIROLOGY

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

(2012) Federico Lazzaro et al.   MOLECULAR CELL

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells

(2012) John L. Goodier et al.   PLoS Genetics

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease

(2011) Suzanna L. Bailey et al.   DNA REPAIR

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

Somatic expression of LINE-1 elements in human tissues

(2010) Victoria P. Belancio et al.   NUCLEIC ACIDS RESEARCH

Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease

(2009) Mary K. Crow   AUTOIMMUNITY

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY