PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

TREX1 degrades the 3′ end of the small DNA oligonucleotide products of nucleotide excision repair in human cells

(2022) Seon Hee Kim et al.   NUCLEIC ACIDS RESEARCH

Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro

(2022) Xiaoying Wei et al.   NUCLEIC ACIDS RESEARCH

PML isoforms: a molecular basis for PML pleiotropic functions

(2022) Martina Uggè et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis of human TREX1 DNA degradation and autoimmune disease

(2022) Wen Zhou et al.   Nature Communications

Transposable Element Regulation and Expression in Cancer

(2021) Erin E. Grundy et al.   FEBS Journal

ER-directed TREX1 limits cGAS activation at micronuclei

(2021) Lisa Mohr et al.   MOLECULAR CELL

Fossilized cell structures identify an ancient origin for the teleost whole-genome duplication

(2021) Donald Davesne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic instability signals offer diagnostic possibility in early cancer detection

(2021) Sarah Killcoyne et al.   TRENDS IN GENETICS

Aberrantly High Levels of Somatic LINE-1 Expression and Retrotransposition in Human Neurological Disorders

(2020) Diane M. Terry et al.   Frontiers in Genetics

Characterization of cGAS homologs in innate and adaptive mucosal immunities in zebrafish gives evolutionary insights into cGAS-STING pathway

(2020) Zhi-fei Liu et al.   FASEB JOURNAL

cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1

(2020) Marcin Gamdzyk et al.   MOLECULAR NEUROBIOLOGY

PML nuclear bodies and chromatin dynamics: catch me if you can!

(2020) Armelle Corpet et al.   NUCLEIC ACIDS RESEARCH

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

(2019) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

(2019) Carina C. de Oliveira Mann et al.   Cell Reports

Deep evolutionary origin of limb and fin regeneration

(2019) Sylvain Darnet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination

(2019) Kathleen M. Attwood et al.   Biochemistry and Cell Biology

RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition

(2018) Maria Benitez‐Guijarro et al.   EMBO JOURNAL

The functional roles of PML nuclear bodies in genome maintenance

(2018) Hae Ryung Chang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition

(2018) Jongsu Choi et al.   NUCLEIC ACIDS RESEARCH

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

(2018) Kuan-Wei Huang et al.   PLOS BIOLOGY

Structural insights into the duplex DNA processing of TREX2

(2018) Hiu-Lo Cheng et al.   NUCLEIC ACIDS RESEARCH

Impaired STING Pathway in Human Osteosarcoma U2OS Cells Contributes to the Growth of ICP0-Null Mutant Herpes Simplex Virus

(2017) Thibaut Deschamps et al.   JOURNAL OF VIROLOGY

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

(2017) Xingyue He et al.   Nature Chemical Biology

Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

(2017) Peng Li et al.   NUCLEIC ACIDS RESEARCH

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

(2017) Martin Kucej et al.   Cell Reports

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

The impact of transposable elements on mammalian development

(2016) Jose L. Garcia-Perez et al.   DEVELOPMENT

Emerging Role of PML Nuclear Bodies in Innate Immune Signaling

(2016) Myriam Scherer et al.   JOURNAL OF VIROLOGY

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

(2016) Ingo Braasch et al.   NATURE GENETICS

ADAR1 restricts LINE-1 retrotransposition

(2016) Elisa Orecchini et al.   NUCLEIC ACIDS RESEARCH

Restricting retrotransposons: a review

(2016) John L. Goodier   Mobile DNA

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

(2016) Christelle Brégnard et al.   EBioMedicine

The origin and early phylogenetic history of jawed vertebrates

(2015) Martin D. Brazeau et al.   NATURE

Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

(2015) Jordan Pinder et al.   NUCLEIC ACIDS RESEARCH

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

(2015) Kyle J. Seamon et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer

(2015) M E Buczek et al.   ONCOGENE

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

(2015) Yoong Wearn Lim et al.   eLife

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity

(2015) Martina Haller et al.   Autophagy

PML control of cytokine signaling

(2014) Ghizlane Maarifi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

The 3′–5′ DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response

(2014) Takuya Miyazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies

(2014) Lam-Tung Nguyen et al.   MOLECULAR BIOLOGY AND EVOLUTION

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

(2014) Xiaomei Wu et al.   NUCLEIC ACIDS RESEARCH

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

(2013) Fiona T. M. Chang et al.   NUCLEIC ACIDS RESEARCH

Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

(2013) Axel V. Horn et al.   NUCLEIC ACIDS RESEARCH

Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins

(2013) Nataša Lindič et al.   Retrovirology

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

(2013) Ke Zhao et al.   Cell Reports

Differential Roles of PML Isoforms

(2013) Sébastien Nisole et al.   Frontiers in Oncology

How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T–product complexes

(2012) Yu-Yuan Hsiao et al.   NUCLEIC ACIDS RESEARCH

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells

(2012) John L. Goodier et al.   PLoS Genetics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pml represses tumour progression through inhibition of mTOR

(2011) Rosa Bernardi et al.   EMBO Molecular Medicine

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

(2011) Marie-Claude Geoffroy et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

SUMO Pathway Dependent Recruitment of Cellular Repressors to Herpes Simplex Virus Type 1 Genomes

(2011) Delphine Cuchet-Lourenço et al.   PLoS Pathogens

LINE-1 Retrotransposition Activity in Human Genomes

(2010) Christine R. Beck et al.   CELL

Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage

(2010) Markus Christmann et al.   NUCLEIC ACIDS RESEARCH

Somatic expression of LINE-1 elements in human tissues

(2010) Victoria P. Belancio et al.   NUCLEIC ACIDS RESEARCH

Nucleases: diversity of structure, function and mechanism

(2010) Wei Yang   QUARTERLY REVIEWS OF BIOPHYSICS

Characterization of LINE-1 Ribonucleoprotein Particles

(2010) Aurélien J. Doucet et al.   PLoS Genetics

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease: Figure 1

(2009) Tomas Lindahl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

(2009) S. Capella-Gutierrez et al.   BIOINFORMATICS

The impact of retrotransposons on human genome evolution

(2009) Richard Cordaux et al.   NATURE REVIEWS GENETICS

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

(2008) John L. Goodier et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution

(2008) J. B. Dacks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA