Control of Tissue Development by Morphogens

Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids

(2022) Lizhong Liu et al.   Nature Communications

A role for Flower and cell death in controlling morphogen gradient scaling

(2022) Marisa M. Merino et al.   NATURE CELL BIOLOGY

Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

(2022) Akshay Patel et al.   Nature Communications

Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription

(2022) Gonçalo Fernandes et al.   eLife

The unappreciated generative role of cell movements in pattern formation

(2022) Timothy Fulton et al.   Royal Society Open Science

Long-range morphogen gradient formation by cell-to-cell signal propagation

(2022) Johanna E M Dickmann et al.   PHYSICAL BIOLOGY

Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming

(2022) Diana Pinheiro et al.   Nature Physics

Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model

(2022) Timo Kuhn et al.   Nature Communications

Patterning principles of morphogen gradients

(2022) M. Fethullah Simsek et al.   Open Biology

Patterning on the move: the effects of Hh morphogen source movement on signaling dynamics

(2022) D. G. Míguez et al.   DEVELOPMENT

Periodic inhibition of Erk activity drives sequential somite segmentation

(2022) M. Fethullah Simsek et al.   NATURE

The BMP signaling gradient is interpreted through concentration thresholds in dorsal–ventral axial patterning

(2021) Hannah Greenfeld et al.   PLOS BIOLOGY

The many bits of positional information

(2021) Gašper Tkačik et al.   DEVELOPMENT

Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks

(2021) Katherine Exelby et al.   DEVELOPMENT

Generation of extracellular morphogen gradients: the case for diffusion

(2021) Kristina S. Stapornwongkul et al.   NATURE REVIEWS GENETICS

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

(2021) Lucy Brunt et al.   Nature Communications

Improving the understanding of cytoneme-mediated morphogen gradients by in silico modeling

(2021) Adrián Aguirre-Tamaral et al.   PLoS Computational Biology

The pattern of nodal morphogen signaling is shaped by co-receptor expression

(2021) Nathan D Lord et al.   eLife

Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions

(2021) Meritxell Sáez et al.   Cell Systems

Morphogen gradient scaling by recycling of intracellular Dpp

(2021) Maria Romanova-Michaelides et al.   NATURE

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

(2021) Shinya Matsuda et al.   Nature Communications

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers

(2020) Lara Barrio et al.   DEVELOPMENTAL CELL

Global shape of Toll activation is determined by wntD enhancer properties

(2020) Neta Rahimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin

(2020) Rita Mateus et al.   Cell Reports

Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors

(2020) Yilun Zhu et al.   DEVELOPMENTAL CELL

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

(2020) Ian J. McGough et al.   NATURE

Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand

(2020) Bradley M. Wierbowski et al.   DEVELOPMENTAL CELL

Mesoderm patterning by a dynamic gradient of retinoic acid signalling

(2020) Ségolène Bernheim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

An adhesion code ensures robust pattern formation during tissue morphogenesis

(2020) Tony Y.-C. Tsai et al.   SCIENCE

Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation

(2020) Francesca B. Tuazon et al.   Cell Reports

Control of Drosophila wing size by morphogen range and hormonal gating

(2020) Joseph Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimal Decoding of Cellular Identities in a Genetic Network

(2019) Mariela D. Petkova et al.   CELL

Organization of Embryonic Morphogenesis via Mechanical Information

(2019) Dipjyoti Das et al.   DEVELOPMENTAL CELL

Positional information and tissue scaling during development and regeneration

(2019) Daniel Čapek et al.   DEVELOPMENT

Critical Point in Self-Organized Tissue Growth

(2018) Daniel Aguilar-Hidalgo et al.   PHYSICAL REVIEW LETTERS

Morphogen gradient reconstitution reveals Hedgehog pathway design principles

(2018) Pulin Li et al.   SCIENCE

A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila

(2018) Berta Verd et al.   PLOS BIOLOGY

Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors

(2018) Ruben Perez-Carrasco et al.   Cell Systems

Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis

(2018) Lucia Durrieu et al.   Molecular Systems Biology

Scale-invariant patterning by size-dependent inhibition of Nodal signalling

(2018) María Almuedo-Castillo et al.   NATURE CELL BIOLOGY

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

(2018) Benjamin Mattes et al.   eLife

Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

(2018) Lijuan Du et al.   eLife

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

(2018) Mustafa Mir et al.   eLife

Decoding of position in the developing neural tube from antiparallel morphogen gradients

(2017) Marcin Zagorski et al.   SCIENCE

Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

(2017) Pablo Sanchez Bosch et al.   eLife

Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo

(2017) Anqi Huang et al.   eLife

Systems biology derived source-sink mechanism of BMP gradient formation

(2017) Joseph Zinski et al.   eLife

Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

(2017) Autumn P Pomreinke et al.   eLife

Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks

(2016) Enrico Cannavò et al.   CURRENT BIOLOGY

Scaling of morphogenetic patterns in reaction-diffusion systems

(2016) Manan’Iarivo Rasolonjanahary et al.   JOURNAL OF THEORETICAL BIOLOGY

Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation

(2016) Keisuke Sako et al.   Cell Reports

Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches

(2016) Ruben Perez-Carrasco et al.   PLoS Computational Biology

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

(2016) Emiko Mihara et al.   eLife

Bending Gradients: How the Intestinal Stem Cell Gets Its Home

(2015) Amy E. Shyer et al.   CELL

A local difference in Hedgehog signal transduction increases mechanical cell bond tension and biases cell intercalations along theDrosophilaanteroposterior compartment boundary

(2015) Katrin Rudolf et al.   DEVELOPMENT

Positional information and reaction-diffusion: two big ideas in developmental biology combine

(2015) J. B. A. Green et al.   DEVELOPMENT

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila

(2015) Honggang Wu et al.   Nature Communications

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

(2015) Julien Dubrulle et al.   eLife

The Role of Mathematical Models in Understanding Pattern Formation in Developmental Biology

(2014) David M. Umulis et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Zelda Potentiates Morphogen Activity by Increasing Chromatin Accessibility

(2014) Sun Melody Foo et al.   CURRENT BIOLOGY

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

(2014) M. Cohen et al.   DEVELOPMENT

Growth control by a moving morphogen gradient during Drosophila eye development

(2014) Ortrud Wartlick et al.   DEVELOPMENT

Scaling morphogen gradients during tissue growth by a cell division rule

(2014) I. Averbukh et al.   DEVELOPMENT

Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning

(2014) Benoit Sorre et al.   DEVELOPMENTAL CELL

Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms

(2014) W.-C. Lo et al.   Journal of the Royal Society Interface

PLETHORA gradient formation mechanism separates auxin responses

(2014) Ari Pekka Mähönen et al.   NATURE

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

Carrier of Wingless (Cow), a Secreted Heparan Sulfate Proteoglycan, Promotes Extracellular Transport of Wingless

(2014) Yung-Heng Chang et al.   PLoS One

Coordination of progenitor specification and growth in mouse and chick spinal cord

(2014) A. Kicheva et al.   SCIENCE

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

A unified design space of synthetic stripe-forming networks

(2014) Yolanda Schaerli et al.   Nature Communications

Dynamic scaling of morphogen gradients on growing domains

(2014) Patrick Fried et al.   Nature Communications

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

(2014) Neha Vyas et al.   Scientific Reports

Specified Neural Progenitors Sort to Form Sharp Domains after Noisy Shh Signaling

(2013) Fengzhu Xiong et al.   CELL

Mechanisms of scaling in pattern formation

(2013) D. M. Umulis et al.   DEVELOPMENT

Morphogen transport

(2013) P. Muller et al.   DEVELOPMENT

The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands

(2013) Marie-Christine Ramel et al.   DEVELOPMENTAL BIOLOGY

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

Pattern Formation by Graded and Uniform Signals in the Early Drosophila Embryo

(2012) Jitendra S. Kanodia et al.   BIOPHYSICAL JOURNAL

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes

(2012) Hongtao Chen et al.   CELL

Investigating the principles of morphogen gradient formation: from tissues to cells

(2012) Anna Kicheva et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling

(2012) Tony Oosterveen et al.   DEVELOPMENTAL CELL

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

(2012) K. A. Peterson et al.   GENES & DEVELOPMENT

A gene regulatory motif that generates oscillatory or multiway switch outputs

(2012) J. Panovska-Griffiths et al.   Journal of the Royal Society Interface

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Dynamics of TGF-  signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4

(2012) A. Warmflash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System

(2012) P. Muller et al.   SCIENCE

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

Mutual Repression Enhances the Steepness and Precision of Gene Expression Boundaries

(2012) Thomas R. Sokolowski et al.   PLoS Computational Biology

Mathematical models of morphogen gradients and their effects on gene expression

(2012) Stanislav Y. Shvartsman et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Measurement and Perturbation of Morphogen Lifetime: Effects on Gradient Shape

(2011) Jeffrey A. Drocco et al.   BIOPHYSICAL JOURNAL

Expansion-Repression Mechanism for Scaling the Dpp Activation Gradient in Drosophila Wing Imaginal Discs

(2011) Danny Ben-Zvi et al.   CURRENT BIOLOGY

Scaling of the Bicoid morphogen gradient by a volume-dependent production rate

(2011) D. Cheung et al.   DEVELOPMENT

Sequentially acting Sox transcription factors in neural lineage development

(2011) M. Bergsland et al.   GENES & DEVELOPMENT

Modeling morphogen gradient formation from arbitrary realistically shaped sources

(2011) S. Dalessi et al.   JOURNAL OF THEORETICAL BIOLOGY

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

(2011) K. A. Mulligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo

(2011) M. W. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Dpp Signaling and Proliferation Control

(2011) O. Wartlick et al.   SCIENCE

Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc

(2011) Fisun Hamaratoglu et al.   PLOS BIOLOGY

The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA

(2011) Shawn C. Little et al.   PLOS BIOLOGY

Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition

(2011) Melissa M. Harrison et al.   PLoS Genetics

How Long Does It Take to Establish a Morphogen Gradient?

(2010) Alexander M. Berezhkovskii et al.   BIOPHYSICAL JOURNAL

High Mobility of Bicoid Captured by Fluorescence Correlation Spectroscopy: Implication for the Rapid Establishment of Its Gradient

(2010) Asmahan Abu-Arish et al.   BIOPHYSICAL JOURNAL

The gap gene network

(2010) Johannes Jaeger   CELLULAR AND MOLECULAR LIFE SCIENCES

An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients

(2010) James Cotterell et al.   Molecular Systems Biology

Emerging properties of animal gene regulatory networks

(2010) Eric H. Davidson   NATURE

A random cell motility gradient downstream of FGF controls elongation of an amniote embryo

(2010) Bertrand Bénazéraf et al.   NATURE

Control of Dpp morphogen signalling by a secreted feedback regulator

(2010) Robin Vuilleumier et al.   NATURE CELL BIOLOGY

Scaling of morphogen gradients by an expansion-repression integral feedback control

(2010) D. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

The extracellular regulation of bone morphogenetic protein signaling

(2009) D. Umulis et al.   DEVELOPMENT

Quantification of growth asymmetries in developing epithelia

(2009) T. Bittig et al.   EUROPEAN PHYSICAL JOURNAL E

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

(2009) Lea Goentoro et al.   MOLECULAR CELL

Accuracy of positional information provided by multiple morphogen gradients with correlated noise

(2009) Yoshihiro Morishita et al.   PHYSICAL REVIEW E

The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-mediated Patterning

(2009) A. D. Lander et al.   Cold Spring Harbor Perspectives in Biology

Morphogen Gradient Formation

(2009) O. Wartlick et al.   Cold Spring Harbor Perspectives in Biology

Canalization of Gene Expression in the Drosophila Blastoderm by Gap Gene Cross Regulation

(2009) Manu et al.   PLOS BIOLOGY

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Precise Registration of Gene Expression Boundaries by a Repressive Morphogen in Drosophila

(2008) Danyang Yu et al.   CURRENT BIOLOGY

Precision of the Dpp gradient

(2008) T. Bollenbach et al.   DEVELOPMENT

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

(2008) Jianjian Zhu et al.   DEVELOPMENTAL CELL

Scaling of the BMP activation gradient in Xenopus embryos

(2008) Danny Ben-Zvi et al.   NATURE

Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface

(2007) Takuya Akiyama et al.   DEVELOPMENTAL BIOLOGY