Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms

Application of chimeric glucanase comprising mutanase and dextranase for prevention of dental biofilm formation

(2015) Ryoko Otsuka et al.   MICROBIOLOGY AND IMMUNOLOGY

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

(2015) Sean Stowe et al.   Current Drug Delivery

Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria

(2014) Joseph P. Gerdt et al.   ACS Chemical Biology

Novel Strategy for Biofilm Inhibition by Using Small Molecules Targeting Molecular Chaperone DnaK

(2014) Ken-ichi Arita-Morioka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quorum quenching is an antivirulence strategy employed by endophytic bacteria

(2014) Parijat Kusari et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bacterial surface appendages as targets for novel antibacterial therapeutics

(2014) David Steadman et al.   Future Microbiology

Mobility and temperature resistance of trehalose mycolates as key characteristics of the outer membrane ofMycobacterium tuberculosis

(2014) Federica Migliardo et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Degradation of fluoroquinolone antibiotics and identification of metabolites/transformation products by liquid chromatography–tandem mass spectrometry

(2014) Alexandra S. Maia et al.   JOURNAL OF CHROMATOGRAPHY A

Disruption of heterotypic community development byPorphyromonas gingivaliswith small molecule inhibitors

(2014) C.J. Wright et al.   Molecular Oral Microbiology

Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides

(2014) Indran Mathavan et al.   Nature Chemical Biology

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Microbiological effects of sublethal levels of antibiotics

(2014) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Novel bacterial ADP-ribosylating toxins: structure and function

(2014) Nathan C. Simon et al.   NATURE REVIEWS MICROBIOLOGY

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity

(2014) Hung The Dang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

(2014) Ritu Bansal-Mutalik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global dissemination of a multidrug resistant Escherichia coli clone

(2014) N. K. Petty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy

(2014) Agnieszka Górska et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Emergence and spread of antibiotic resistance: setting a parameter space

(2014) José Luis Martínez et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Reversal ofMycobacterium tuberculosisphenotypic drug resistance by 2-aminoimidazole-based small molecules

(2014) David F. Ackart et al.   Pathogens and Disease

Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

(2013) Tyler L. Harris et al.   ACS Chemical Biology

The molecular dissection of the chaperone–usher pathway

(2013) Sebastian Geibel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Low Helicobacter pylori primary resistance to clarithromycin in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil

(2013) Rodrigo Buzinaro Suzuki et al.   BMC GASTROENTEROLOGY

Non-nativeN-AroylL-Homoserine Lactones Are Potent Modulators of the Quorum Sensing Receptor RpaR inRhodopseudomonas palustris

(2013) Christine E. McInnis et al.   CHEMBIOCHEM

Modulation of Curli Assembly and Pellicle Biofilm Formation by Chemical and Protein Chaperones

(2013) Emma K. Andersson et al.   CHEMISTRY & BIOLOGY

Chemical attenuation of pilus function and assembly in Gram-negative bacteria

(2013) Alvin W.H. Lo et al.   CURRENT OPINION IN MICROBIOLOGY

Biologically inspired strategies for combating bacterial biofilms

(2013) Meghan S Blackledge et al.   CURRENT OPINION IN PHARMACOLOGY

Pertussis resurgence: waning immunity and pathogen adaptation – two sides of the same coin

(2013) F. R. MOOI et al.   EPIDEMIOLOGY AND INFECTION

Quorum sensing inhibitors: a patent review

(2013) Tianyu Jiang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

(2013) Roberta J Worthington et al.   Future Medicinal Chemistry

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

(2013) Alvin W. H. Lo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhibition of multidrug efflux as a strategy to prevent biofilm formation

(2013) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Crystal Structure of Shiga Toxin Type 2 with Bound Disaccharide Guides the Design of a Heterobifunctional Toxin Inhibitor

(2013) Jared M. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indole inhibits bacterial quorum sensing signal transmission by interfering with quorum sensing regulator folding

(2013) J. Kim et al.   MICROBIOLOGY-SGM

Single-molecule interrogation of a bacterial sugar transporter allows the discovery of an extracellular inhibitor

(2013) Lingbing Kong et al.   Nature Chemistry

Control of pathogens and pathobionts by the gut microbiota

(2013) Nobuhiko Kamada et al.   NATURE IMMUNOLOGY

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance

(2013) Adam C. Palmer et al.   NATURE REVIEWS GENETICS

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indole–triazole conjugates are selective inhibitors and inducers of bacterial biofilms

(2013) Marine J. Minvielle et al.   MedChemComm

Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance

(2013) Fernanda Guilhelmelli et al.   Frontiers in Microbiology

Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones

(2012) Danielle M. Stacy et al.   ACS Chemical Biology

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

(2012) Richele J. Thompson et al.   BIOCHEMISTRY

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure–activity study

(2012) Erik Chorell et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria

(2012) Robert E. Furlani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides

(2012) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

(2012) Istvan Horvath et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein transport across the cell wall of monoderm Gram-positive bacteria

(2012) Brian M. Forster et al.   MOLECULAR MICROBIOLOGY

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

N-Substituted 2-aminoimidazoleinhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

(2012) Andrew A. Yeagley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota

(2012) N. Kamada et al.   SCIENCE

Fresh Approaches to Anti-Infective Therapies

(2012) C. Nathan   Science Translational Medicine

D-Alanylation of Lipoteichoic Acids Confers Resistance to Cationic Peptides in Group B Streptococcus by Increasing the Cell Wall Density

(2012) Ron Saar-Dover et al.   PLoS Pathogens

Selective Advantage of Resistant Strains at Trace Levels of Antibiotics: a Simple and Ultrasensitive Color Test for Detection of Antibiotics and Genotoxic Agents

(2011) Anne Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Correlation of Daptomycin Resistance in a ClinicalStaphylococcus aureusStrain with Increased Cell Wall Teichoic Acid Production and d-Alanylation

(2011) Ute Bertsche et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

(2011) Oliver Schwardt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stability, denaturation and refolding of Mycobacterium tuberculosis MfpA, a DNA mimicking protein that confers antibiotic resistance

(2011) Sergei Khrapunov et al.   BIOPHYSICAL CHEMISTRY

Contribution of bacterial outer membrane vesicles to innate bacterial defense

(2011) Andrew J Manning et al.   BMC MICROBIOLOGY

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

(2011) Lingling Peng et al.   CHEMICAL COMMUNICATIONS

Combating biofilms

(2011) Liang Yang et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems

(2011) Cara N Wilder et al.   ISME Journal

Quorum quenching quandary: resistance to antivirulence compounds

(2011) Toshinari Maeda et al.   ISME Journal

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

(2011) Benoit Chassaing et al.   JOURNAL OF CLINICAL INVESTIGATION

A Strategy for Antagonizing Quorum Sensing

(2011) Guozhou Chen et al.   MOLECULAR CELL

Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

(2011) Gilles Phan et al.   NATURE

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

The Sociomicrobiology of Antivirulence Drug Resistance: a Proof of Concept

(2011) B. Mellbye et al.   mBio

The Genomic Enzymology of Antibiotic Resistance

(2010) Mariya Morar et al.   Annual Review of Genetics

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

(2010) Cynthia A. Bunders et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

(2010) J.B. Kaplan   JOURNAL OF DENTAL RESEARCH

Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles

(2010) Kumkum Ganguly et al.   JOURNAL OF DRUG TARGETING

Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing

(2010) Colin A. Lowery et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity

(2010) Erik Chorell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of multidrug-resistant pathogens in health-care-associated pneumonia

(2010) Marco Falcone et al.   LANCET INFECTIOUS DISEASES

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Can Bacteria Evolve Resistance to Quorum Sensing Disruption?

(2010) Tom Defoirdt et al.   PLoS Pathogens

Updated Functional Classification of  -Lactamases

(2009) K. Bush et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors

(2009) Davide Antoniani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Quorum sensing inhibitors: a patent overview

(2009) Jiachuan Pan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antimicrobial and antibiofilm efficacy of triclosan and DispersinB(R) combination

(2009) R. O. Darouiche et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comparison of different methods for thin section EM analysis of Mycobacterium smegmatis

(2009) C.K.E. BLECK et al.   JOURNAL OF MICROSCOPY

Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms

(2009) E. Karatan et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A Quorum-Sensing Antagonist Targets Both Membrane-Bound and Cytoplasmic Receptors and Controls Bacterial Pathogenicity

(2009) Lee R. Swem et al.   MOLECULAR CELL

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

(2009) Jemy A Gutierrez et al.   Nature Chemical Biology

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

(2009) Robert W. Huigens III et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The role of natural environments in the evolution of resistance traits in pathogenic bacteria

(2009) J. L. Martinez   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

(2008) Justin J. Richards et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants

(2008) María B Sánchez et al.   BMC MICROBIOLOGY

An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion

(2008) Heather B. Felise et al.   Cell Host & Microbe

Comparative Analyses ofN-Acylated Homoserine Lactones Reveal Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing

(2008) Grant D. Geske et al.   CHEMBIOCHEM

Interspecies and interkingdom communication mediated by bacterial quorum sensing

(2008) Colin A. Lowery et al.   CHEMICAL SOCIETY REVIEWS

Small Molecules for Interference with Cell-Cell-Communication Systems in Gram-Negative Bacteria

(2008) Joost Janssens et al.   CURRENT MEDICINAL CHEMISTRY

AHL-driven quorum-sensing circuits: their frequency and function among the Proteobacteria

(2008) Rebecca J Case et al.   ISME Journal

Foggy D-shaped zone of inhibition in Staphylococcus aureus owing to a dual character of both inducible and constitutive resistance to macrolide–lincosamide–streptogramin B

(2008) Eun-Jeong Yoon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State

(2008) B. Zuber et al.   JOURNAL OF BACTERIOLOGY

ARDB--Antibiotic Resistance Genes Database

(2008) B. Liu et al.   NUCLEIC ACIDS RESEARCH

Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure

(2008) C. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteria Subsisting on Antibiotics

(2008) G. Dantas et al.   SCIENCE

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

(2008) Les Dethlefsen et al.   PLOS BIOLOGY

FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling

(2008) Ali A. Ashkar et al.   PLoS Pathogens

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY