Novel bacterial ADP-ribosylating toxins: structure and function

Mechanism of Tc toxin action revealed in molecular detail

(2014) Dominic Meusch et al.   NATURE

Clostridium difficiletoxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

(2014) Carsten Schwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella entericadelivers its genotoxin through outer membrane vesicles secreted from infected cells

(2013) Riccardo Guidi et al.   CELLULAR MICROBIOLOGY

Signaling networks of Rho GTPases in cell motility

(2013) Samer Hanna et al.   CELLULAR SIGNALLING

The biosynthesis and biological function of diphthamide

(2013) Xiaoyang Su et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Pseudomonas HopU1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7

(2013) Valerie Nicaise et al.   EMBO JOURNAL

Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin

(2013) Jeongmin Song et al.   NATURE

A syringe-like injection mechanism in Photorhabdus luminescens toxins

(2013) Christos Gatsogiannis et al.   NATURE

Strain-alleviation model of ADP-ribosylation

(2013) Thomas Jank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex

(2013) Toshiharu Tsurumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To harm or not to harm? On the evolution and expression of virulence in group A streptococci

(2013) Kristofer Wollein Waldetoft et al.   TRENDS IN MICROBIOLOGY

Prediction of molecular mimicry candidates in human pathogenic bacteria

(2013) Andrew C Doxey et al.   Virulence

Novel Cholix Toxin Variants, ADP-Ribosylating Toxins in Vibrio cholerae Non-O1/Non-O139 Strains, and Their Pathogenicity

(2012) Sharda Prasad Awasthi et al.   INFECTION AND IMMUNITY

The 1.8 Å Cholix Toxin Crystal Structure in Complex with NAD+and Evidence for a New Kinetic Model

(2012) Robert J. Fieldhouse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and Biological Characterization of Streptococcal SpyA-mediated ADP-ribosylation of Intermediate Filament Protein Vimentin

(2012) Laura M. Icenogle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A first step in bringing typhoid fever out of the closet

(2012) John Maurice   LANCET

SpyA is a membrane-bound ADP-ribosyltransferase of Streptococcus pyogenes which modifies a streptococcal peptide, SpyB

(2012) Natalia Korotkova et al.   MOLECULAR MICROBIOLOGY

From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

(2012) Nicholas K. Priest et al.   NATURE REVIEWS MICROBIOLOGY

A Comparison of Computational Methods for Identifying Virulence Factors

(2012) Lu-Lu Zheng et al.   PLoS One

Curli Functional Amyloid Systems Are Phylogenetically Widespread and Display Large Diversity in Operon and Protein Structure

(2012) Morten S. Dueholm et al.   PLoS One

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

(2011) R. J. Kreitman et al.   CLINICAL CANCER RESEARCH

Activation of plant pattern-recognition receptors by bacteria

(2011) Cécile Segonzac et al.   CURRENT OPINION IN MICROBIOLOGY

New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin

(2011) Holger Barth et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Actin as target for modification by bacterial protein toxins

(2011) Klaus Aktories et al.   FEBS Journal

A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

(2011) John E. Weldon et al.   FEBS Journal

SpyA, a C3-Like ADP-Ribosyltransferase, Contributes to Virulence in a Mouse Subcutaneous Model of Streptococcus pyogenes Infection

(2011) Jessica S. Hoff et al.   INFECTION AND IMMUNITY

Structure Function Analysis of an ADP-ribosyltransferase Type III Effector and Its RNA-binding Target in Plant Immunity

(2011) Byeong-ryool Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

(2011) P. Papatheodorou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-Mediated Endocytosis

(2011) H. Ewers et al.   Cold Spring Harbor Perspectives in Biology

Photox, a Novel Actin-targeting Mono-ADP-ribosyltransferase fromPhotorhabdus luminescens

(2010) Danielle D. Visschedyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts

(2010) F. Boato et al.   JOURNAL OF CELL SCIENCE

Plant immunity: towards an integrated view of plant–pathogen interactions

(2010) Peter N. Dodds et al.   NATURE REVIEWS GENETICS

Photorhabdus luminescens Toxins ADP-Ribosylate Actin and RhoA to Force Actin Clustering

(2010) A. E. Lang et al.   SCIENCE

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Diversity and distribution of cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae

(2010) Alexandra E. Purdy et al.   Environmental Microbiology Reports

Cholera- and Anthrax-Like Toxins Are among Several New ADP-Ribosyltransferases

(2010) Robert J. Fieldhouse et al.   PLoS Computational Biology

Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs

(2010) Edward A. Berger et al.   PLoS Pathogens

Photorhabdusand a Host of Hosts

(2009) Nick R. Waterfield et al.   Annual Review of Microbiology

Initial characterization of an immunotoxin constructed from domains II and III of cholera exotoxin

(2009) Robert Sarnovsky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Selective and specific internalization of clostridial C3 ADP-ribosyltransferases into macrophages and monocytes

(2009) Jörg Fahrer et al.   CELLULAR MICROBIOLOGY

Innate Immunity in Plants: An Arms Race Between Pattern Recognition Receptors in Plants and Effectors in Microbial Pathogens

(2009) T. Boller et al.   SCIENCE

The β-thymosins: Intracellular and extracellular activities of a versatile actin binding protein family

(2009) Hans Georg Mannherz et al.   CELL MOTILITY AND THE CYTOSKELETON

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

(2009) Carsten Schwan et al.   PLoS Pathogens

Delivery of a Salmonella Typhi Exotoxin from a Host Intracellular Compartment

(2008) Stefania Spanò et al.   Cell Host & Microbe

The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin

(2008) Pradeep K. Gupta et al.   CELLULAR MICROBIOLOGY

A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation

(2008) Markus Höltje et al.   FASEB JOURNAL

Cholix Toxin, a Novel ADP-ribosylating Factor fromVibrio cholerae

(2008) René Jørgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens  -toxin

(2008) H. Tsuge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system

(2007) Silvia Vilches et al.   MICROBIAL PATHOGENESIS