Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

Anti-biofilm agents: recent breakthrough against multi-drug resistantStaphylococcus aureus

(2014) Pooi Y. Chung et al.   Pathogens and Disease

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle

(2013) A. Aria Tzika et al.   PLoS One

A Quorum Sensing Small Volatile Molecule Promotes Antibiotic Tolerance in Bacteria

(2013) Yok-Ai Que et al.   PLoS One

Quorum sensing inhibitors: how strong is the evidence?

(2013) Tom Defoirdt et al.   TRENDS IN MICROBIOLOGY

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

(2013) Aravindan Ilangovan et al.   PLoS Pathogens

Identification of Small-Molecule Antagonists of the Pseudomonas aeruginosa Transcriptional Regulator PqsR: Biophysically Guided Hit Discovery and Optimization

(2012) Tobias Klein et al.   ACS Chemical Biology

A method for high throughput determination of viable bacteria cell counts in 96-well plates

(2012) Ronen Hazan et al.   BMC MICROBIOLOGY

Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

(2012) Cenbin Lu et al.   CHEMISTRY & BIOLOGY

7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa

(2012) Jin-Hyung Lee et al.   FEMS MICROBIOLOGY LETTERS

Fourteen years in resistance

(2012) David M. Livermore   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Phylogenetic Classification of Diverse LysR-Type Transcriptional Regulators of a Model Prokaryote Geobacter sulfurreducens

(2012) Julia Krushkal et al.   JOURNAL OF MOLECULAR EVOLUTION

Signaling-mediated bacterial persister formation

(2012) Nicole M Vega et al.   Nature Chemical Biology

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals

(2012) Sarah Schmidt Grant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics, microbiota, and immune defense

(2012) Carles Ubeda et al.   TRENDS IN IMMUNOLOGY

The Quorum Sensing Volatile Molecule 2-Amino Acetophenon Modulates Host Immune Responses in a Manner that Promotes Life with Unwanted Guests

(2012) Arunava Bandyopadhaya et al.   PLoS Pathogens

Bacterial persisters tolerate antibiotics by not producing hydroxyl radicals

(2011) Jun-Seob Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies

(2011) M. Fauvart et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Innate immune responses to Pseudomonas aeruginosa infection

(2011) Elise G. Lavoie et al.   MICROBES AND INFECTION

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

The Sociomicrobiology of Antivirulence Drug Resistance: a Proof of Concept

(2011) B. Mellbye et al.   mBio

A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes

(2011) Meenu Kesarwani et al.   PLoS Pathogens

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Bicyclic compounds repress membrane vesicle production andPseudomonasquinolone signal synthesis inPseudomonas aeruginosa

(2010) Yosuke Tashiro et al.   FEMS MICROBIOLOGY LETTERS

Pseudomonas aeruginosa Increases Formation of Multidrug-Tolerant Persister Cells in Response to Quorum-Sensing Signaling Molecules

(2010) N. Moker et al.   JOURNAL OF BACTERIOLOGY

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

Evaluation of Enoyl-Acyl Carrier Protein Reductase Inhibitors as Pseudomonas aeruginosa Quorum-Quenching Reagents

(2010) Liang Yang et al.   MOLECULES

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung

(2010) Amy J Scott-Thomas et al.   BMC Pulmonary Medicine

Homeostatic Interplay between Bacterial Cell-Cell Signaling and Iron in Virulence

(2010) Ronen Hazan et al.   PLoS Pathogens

Bacterial Quorum-Sensing Network Architectures

(2009) Wai-Leung Ng et al.   Annual Review of Genetics

Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors

(2009) L. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

(2009) Paul Williams et al.   CURRENT OPINION IN MICROBIOLOGY

Jamming bacterial communication: New approaches for the treatment of infectious diseases

(2009) Jacqueline Njoroge et al.   EMBO Molecular Medicine

Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa

(2008) Biliana Lesic et al.   BMC MOLECULAR BIOLOGY

Cell-to-cell signalling during pathogenesis

(2008) Christopher T. Parker et al.   CELLULAR MICROBIOLOGY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

PqsD Is Responsible for the Synthesis of 2,4-Dihydroxyquinoline, an Extracellular Metabolite Produced byPseudomonas aeruginosa

(2008) Yong-Mei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H-NS family members function coordinately in an opportunistic pathogen

(2008) S. Castang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES

Why chronic wounds will not heal: a novel hypothesis

(2007) Thomas Bjarnsholt et al.   WOUND REPAIR AND REGENERATION