Article
Infectious Diseases
Hak Jin Lee, Seong Tae Jhang, Hyung Jong Jin
Summary: Resistance to Macrolide-lincosamide-streptogramin B antibiotics is mainly caused by the action of erythromycin ribosome methylation proteins. Research on the conservation region of Erms may lead to the development of inhibitors. The size and chemical properties of side chains in mutants significantly affect their activity.
Article
Microbiology
Yuechen Hu, Lili Ouyang, Duoyun Li, Xiangbin Deng, Hongbo Xu, Zhijian Yu, Yeqing Fang, Jinxin Zheng, Zhong Chen, Haigang Zhang
Summary: This study aimed to explore the antibacterial activity of cethromycin against Staphylococcus aureus (S. aureus) and its relationship with multilocus sequence typing (MLST), erythromycin ribosomal methylase (erm) genes, and macrolide-lincosamide-streptogramin B (MLSB) phenotypes of S. aureus. Results showed that cethromycin had strong antibacterial activity against S. aureus, with some variations in resistance among different MLSTs, erm genes, and MLSB phenotypes.
Article
Microbiology
Xiaoxuan Liu, Xuemei Yang, Lianwei Ye, Edward Wai-Chi Chan, Sheng Chen
Summary: In this study, a conjugative plasmid carrying a novel azithromycin resistance gene was identified from a clinical Klebsiella pneumoniae strain. The plasmid conferred resistance to azithromycin in Salmonella, which is a concern due to limited treatment options for extensively drug-resistant Salmonella. It is important to monitor and prevent the dissemination of this plasmid in Enterobacteriaceae.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, Research & Experimental
Lihua Zhao, Lei Jin, Bin Yang
Summary: The study found that diosmetin suppressed Staphylococcus aureus-induced mastitis by attenuating inflammation and ferroptosis.
Article
Infectious Diseases
Lin Wu, Xia Zhai, Yaojian Jin, Haohao Chen, Junwei Huang
Summary: This study reported a draft whole genome sequence of C. coli isolate obtained from poultry in Jinhua, China, identifying antibiotic resistance and virulence-related genes, which could help track the spread of this resistant clone.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Tao Wang, Wenbo Zhao, Shihong Li, Hong Yao, Qiurong Zhang, Longhua Yang
Summary: This study investigated the prevalence of the erm (B) gene in Campylobacter isolates from retail chicken meat and characterized the erm (B)-harboring isolates. The results showed that 11.8% of the Campylobacter isolates from retail chicken meat carried the erm (B) gene, which indicates a potential threat to public health.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Haiping Wang, Hemu Zhuang, Shujuan Ji, Lu Sun, Feng Zhao, Dandan Wu, Ping Shen, Yan Jiang, Yunsong Yu, Yan Chen
Summary: The study revealed high rates of erythromycin and clindamycin resistance among different MRSA lineages in China, with varying resistance patterns and frequent presence of specific resistance genes in certain MRSA clones. Detection of resistance genes transfer between MRSA isolates in healthcare settings remains an issue, emphasizing the need for infection control measures.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Medicine, Research & Experimental
Lutfun Nahar, Hideharu Hagiya, Takahiro Nada, Koji Iio, Kazuyoshi Gotoh, Osamu Matsushita, Fumio Otsuka
Summary: This study investigated the frequency and genotypic profiles of inducible resistance to macrolide, lincosamide, and streptogramin B (iMLSB) antibiotics in clindamycin-susceptible Staphylococcus aureus isolates. The results showed that approximately 33% of the isolates exhibited iMLSB resistance, predominantly caused by the ermA gene.
ACTA MEDICA OKAYAMA
(2023)
Article
Microbiology
Li Chen, Jinhu Huang, Xinxin Huang, Yuping He, Junjie Sun, Xingyang Dai, Xiaoming Wang, Muhammad Shafiq, Liping Wang
Summary: Various elements carrying macrolide resistance genes were identified in Streptococcus suis, and they were found to be transferred among strains with different serotypes. These elements differ in integration sites and genomic structures, but play an important role in the dissemination of resistance in S. suis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Xuemei Yang, Xiaoxuan Liu, Chen Yang, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen
Summary: This study identified an IncI1 plasmid from a clinical K. pneumoniae strain that carries resistance to both cefotaxime and azithromycin, and is capable of rapidly disseminating among E. coli and Salmonella strains. The study also confirmed the role of the erm(B) gene in mediating azithromycin resistance in various bacterial species, particularly Salmonella. Monitoring the transmission of this plasmid among key Gram-negative bacterial pathogens is crucial in light of its potential impact on antibiotic resistance.
MICROBIOLOGY SPECTRUM
(2021)
Article
Veterinary Sciences
C. M. Camussone, I. G. Reidel, A. Molineri, J. Cicotello, C. Miotti, G. A. Suarez Archilla, C. C. Curti, C. Veaute, L. F. Calvinho
Summary: The present study evaluated the protective ability of a subunit vaccine composed of recombinant molecules against S. aureus infection and assessed the antibody response to the vaccine components. The results showed that the vaccinated animals had a lower proportion of new S. aureus infection and a longer time to new infection compared to the control group. Additionally, the vaccine induced a significant increase in specific antibodies and reduced the hemolytic activity of the native toxin.
RESEARCH IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Janine J. Wilden, Jasmin C. Jacob, Christina Ehrhardt, Stephan Ludwig, Yvonne Boergeling
Summary: This review summarizes recent findings on the immune responses during co-infection with influenza virus and Streptococcus pneumoniae or Staphylococcus aureus, describing how the interactions between different pathogens influence disease outcomes through altered intracellular signaling processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Astrid H. Paulitsch-Fuchs, Benjamin Boedendorfer, Lukas Wolrab, Nicole Eck, Nigel P. Dyer, Birgit Lohberger
Summary: Periprosthetic infections have significant implications for patient care and healthcare costs. This study investigates different surface modifications of implant materials and their impact on biofilm development. The results show a correlation between surface roughness and biofilm characteristics. The findings suggest the need for new implant materials resistant to biofilm infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Dehao Kong, Wangrui Ren, Lin Qi, Yu Zhang, Houwen Chen
Summary: The surface treatment of the metal substrate is crucial in improving the bonding performance of fiber metal laminates. In this study, an anodized film is fabricated on an AZ31B substrate using a saturated Na2SiO3 solution, resulting in enhanced bonding strength between the substrate and carbon-fiber reinforced plastic (CFRP) composites. The porous/linear texture composite structure of the film, which is composed of micro-and nano-pores, is primarily responsible for the improved bonding strength.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Microbiology
Proinnsias G. Fox, Francesca Schiavetti, Rino Rappuoli, Rachel M. McLoughlin, Fabio Bagnoli
Summary: Staphylococcus aureus can evade the human immune response through expression of staphylococcal protein A (SpA), which can form toxic immune complexes with human IgG, leading to necrosis in immune cells. Immune sera raised against SpA can significantly reduce this toxicity. These findings shed light on the mechanisms of SpA-induced leukocyte toxicity and the potential of vaccination strategies to inhibit this process.