Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance

Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study

(2012) Simon R Harris et al.   LANCET INFECTIOUS DISEASES

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Transforming clinical microbiology with bacterial genome sequencing

(2012) Xavier Didelot et al.   NATURE REVIEWS GENETICS

Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak

(2012) Claudio U. Köser et al.   NEW ENGLAND JOURNAL OF MEDICINE

FREQ-Seq: A Rapid, Cost-Effective, Sequencing-Based Method to Determine Allele Frequencies Directly from Mixed Populations

(2012) Lon M. Chubiz et al.   PLoS One

Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing

(2012) E. S. Snitkin et al.   Science Translational Medicine

Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme

(2012) Martijn F. Schenk et al.   PLoS Genetics

Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms

(2011) Vanessa M. D'Costa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

EPISTASIS BUFFERS THE FITNESS EFFECTS OF RIFAMPICIN- RESISTANCE MUTATIONS IN PSEUDOMONAS AERUGINOSA

(2011) Alex R. Hall et al.   EVOLUTION

Antibiotic resistance is ancient

(2011) Vanessa M. D’Costa et al.   NATURE

Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes

(2011) Tami D Lieberman et al.   NATURE GENETICS

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

(2011) Erdal Toprak et al.   NATURE GENETICS

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Hidden Randomness between Fitness Landscapes Limits Reverse Evolution

(2011) Longzhi Tan et al.   PHYSICAL REVIEW LETTERS

Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments

(2011) Q. Zhang et al.   SCIENCE

Rapid Pneumococcal Evolution in Response to Clinical Interventions

(2011) N. J. Croucher et al.   SCIENCE

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

The Genomic Enzymology of Antibiotic Resistance

(2010) Mariya Morar et al.   Annual Review of Genetics

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Chemical decay of an antibiotic inverts selection for resistance

(2010) Adam C Palmer et al.   Nature Chemical Biology

Automated imaging with ScanLag reveals previously undetectable bacterial growth phenotypes

(2010) Irit Levin-Reisman et al.   NATURE METHODS

Evolution of MRSA During Hospital Transmission and Intercontinental Spread

(2010) S. R. Harris et al.   SCIENCE

The human microbiome harbors a diverse reservoir of antibiotic resistance genes

(2010) Morten O.A. Sommer et al.   Virulence

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

Evolutionary Trajectories of Beta-Lactamase CTX-M-1 Cluster Enzymes: Predicting Antibiotic Resistance

(2010) Ângela Novais et al.   PLoS Pathogens

Enhancing antibiotic activity: a strategy to control Acinetobacter infections

(2009) S. Chusri et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Global discovery of adaptive mutations

(2009) Hani Goodarzi et al.   NATURE METHODS

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

Genetic Architecture of Intrinsic Antibiotic Susceptibility

(2009) Hany S. Girgis et al.   PLoS One

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive Epistasis Drives the Acquisition of Multidrug Resistance

(2009) Sandra Trindade et al.   PLoS Genetics

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA