Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

Chemical attenuation of pilus function and assembly in Gram-negative bacteria

(2013) Alvin W.H. Lo et al.   CURRENT OPINION IN MICROBIOLOGY

A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131

(2013) Makrina Totsika et al.   JOURNAL OF INFECTIOUS DISEASES

Structural and energetic basis of folded-protein transport by the FimD usher

(2013) Sebastian Geibel et al.   NATURE

Chemical Inhibitors of the Type Three Secretion System: Disarming Bacterial Pathogens

(2012) Miles C. Duncan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Disarming Bacterial Type IV Secretion

(2012) Todd A. Cameron et al.   CHEMISTRY & BIOLOGY

Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens

(2012) William J Allen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Distinguishing the Contribution of Type 1 Pili from That of Other QseB-Misregulated Factors when QseC Is Absent during Urinary Tract Infection

(2012) Maria Kostakioti et al.   INFECTION AND IMMUNITY

FRED and HYBRID docking performance on standardized datasets

(2012) Mark McGann   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success

(2012) Xiaohua Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural insight in histo-blood group binding by the F18 fimbrial adhesin FedF

(2012) Kristof Moonens et al.   MOLECULAR MICROBIOLOGY

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

(2011) Oliver Schwardt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

(2011) Gilles Phan et al.   NATURE

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

Persistence of Uropathogenic Escherichia coli in the Face of Multiple Antibiotics

(2010) M. G. Blango et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Changing prevalence of Escherichia coli with CTX-M–type extended-spectrum β-lactamases in outpatient urinary E. coli between 2003 and 2008

(2010) Chao Qi et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain

(2010) B. A. Rogers et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

(2010) Tobias Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Structural biology of the chaperone–usher pathway of pilus biogenesis

(2009) Gabriel Waksman et al.   NATURE REVIEWS MICROBIOLOGY

Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria

(2008) Remi Fronzes et al.   EMBO JOURNAL

Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex

(2008) Adinda Wellens et al.   PLoS One

Adaptive mutations in the signal peptide of the type 1 fimbrial adhesin of uropathogenic Escherichia coli

(2008) L. S. Ronald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of Pilus Assembly Reveals a Bacterial Outer Membrane Catalyst

(2008) M. Nishiyama et al.   SCIENCE

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

(2008) Les Dethlefsen et al.   PLOS BIOLOGY

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY