Applying insights from biofilm biology to drug development — can a new approach be developed?

Efficacy of the lithotripsy in treating lower pole renal stones

(2013) Helen Cui et al.   Urolithiasis

Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa

(2012) Rasmus Lykke Marvig et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High β-Lactamase Levels Change the Pharmacodynamics of β-Lactam Antibiotics in Pseudomonas aeruginosa Biofilms

(2012) Wang Hengzhuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing

(2012) Tim Holm Jakobsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

(2012) L. Fernandez et al.   CLINICAL MICROBIOLOGY REVIEWS

Targeting drug tolerance in mycobacteria: a perspective from mycobacterial biofilms

(2012) Mohammad S Islam et al.   Expert Review of Anti-Infective Therapy

The interconnection between biofilm formation and horizontal gene transfer

(2012) Jonas Stenløkke Madsen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The metabolically active subpopulation inPseudomonas aeruginosabiofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

(2012) Wen-Chi Chiang et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Towards diagnostic guidelines for biofilm-associated infections

(2012) Luanne Hall-Stoodley et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Candidaspecies: new insights into biofilm formation

(2012) Mayra Cuéllar-Cruz et al.   Future Microbiology

Interactions between Polymorphonuclear Leukocytes and Pseudomonas aeruginosa Biofilms on Silicone ImplantsIn Vivo

(2012) Maria van Gennip et al.   INFECTION AND IMMUNITY

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

(2012) L. D. Christensen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bacterial stress responses as determinants of antimicrobial resistance

(2012) K. Poole   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms

(2012) Anna Bink et al.   JOURNAL OF INFECTIOUS DISEASES

Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial

(2012) Robert Pickard et al.   LANCET

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

New strategies to prevent catheter-associated urinary tract infections

(2012) Danish M. Siddiq et al.   Nature Reviews Urology

Pseudomonas Biofilms, Cystic Fibrosis, and Phage: a Silver Lining?

(2012) H. Brussow   mBio

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A

(2012) Ravikumar B Shinde et al.   Annals of Clinical Microbiology and Antimicrobials

Guidelines for the prevention of intravascular catheter-related infections

(2011) Naomi P. O'Grady et al.   AMERICAN JOURNAL OF INFECTION CONTROL

In VitroDestruction of Streptococcus pneumoniae Biofilms with Bacterial and Phage Peptidoglycan Hydrolases

(2011) Mirian Domenech et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dynamics of Mutator and Antibiotic-Resistant Populations in a Pharmacokinetic/Pharmacodynamic Model of Pseudomonas aeruginosa Biofilm Treatment

(2011) María D. Macià et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

(2011) Wang Hengzhuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

(2011) BAOLERI LEE et al.   APMIS

Application of a Bacteriophage Lysin To Disrupt Biofilms Formed by the Animal Pathogen Streptococcus suis

(2011) Xiangpeng Meng et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterogeneous bacterial persisters and engineering approaches to eliminate them

(2011) Kyle R Allison et al.   CURRENT OPINION IN MICROBIOLOGY

Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa

(2011) Helga Mikkelsen et al.   ENVIRONMENTAL MICROBIOLOGY

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signalling

(2011) Joana A. Moscoso et al.   ENVIRONMENTAL MICROBIOLOGY

Effects of ginseng onPseudomonas aeruginosamotility and biofilm formation

(2011) Hong Wu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Resolution ofStaphylococcus aureusBiofilm Infection Using Vaccination and Antibiotic Treatment

(2011) Rebecca A. Brady et al.   INFECTION AND IMMUNITY

Bacteriophages as vehicles of the resistome in cystic fibrosis

(2011) J. M. Rolain et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

SagS Contributes to the Motile-Sessile Switch and Acts in Concert with BfiSR To Enable Pseudomonas aeruginosa Biofilm Formation

(2011) O. E. Petrova et al.   JOURNAL OF BACTERIOLOGY

Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

(2011) Kasper Aanaes et al.   Journal of Cystic Fibrosis

Antimicrobial activity of gentamicin palmitate against high concentrations of Staphylococcus aureus

(2011) Clemens Kittinger et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Aspergillus fumigatusbiofilms in the clinical setting

(2011) Frank-Michael C. Müller et al.   MEDICAL MYCOLOGY

A UVC Device for Intra-luminal Disinfection of Catheters: In Vitro Tests on Soft Polymer Tubes Contaminated with Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans

(2011) Jimmy Bak et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Effects of Photoactivated Titanium Dioxide Nanopowders and Coating on Planktonic and Biofilm Growth of Pseudomonas aeruginosa

(2011) Andrea Polo et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Pulmonary Bacteriophage Therapy on Pseudomonas aeruginosa Cystic Fibrosis Strains: First Steps Towards Treatment and Prevention

(2011) Eric Morello et al.   PLoS One

Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

(2011) Morten Alhede et al.   PLoS One

Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments

(2011) Q. Zhang et al.   SCIENCE

Hacking into bacterial biofilms: a new therapeutic challenge

(2011) Christophe Bordi et al.   Annals of Intensive Care

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Synergistic Activities of an Efflux Pump Inhibitor and Iron Chelators against Pseudomonas aeruginosa Growth and Biofilm Formation

(2010) Y. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anin vitromodel of bacterial infections in wounds and other soft tissues

(2010) MARIA WERTHÉN et al.   APMIS

The small regulatory RNA molecule MicA is involved in Salmonella enterica serovar Typhimurium biofilm formation

(2010) Gwendoline Kint et al.   BMC MICROBIOLOGY

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis

(2010) James P Folsom et al.   BMC MICROBIOLOGY

Bacterial Colonization and Infection of Electrophysiological Cardiac Devices Detected With Sonication and Swab Culture

(2010) Martin Rohacek et al.   CIRCULATION

Engineering a novel c-di-GMP-binding protein for biofilm dispersal

(2010) Qun Ma et al.   ENVIRONMENTAL MICROBIOLOGY

Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

(2010) Thomas Bjarnsholt et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Biofilms in chronic infections – a matter of opportunity – monospecies biofilms in multispecies infections

(2010) Mette Burmølle et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The immune system vs.Pseudomonas aeruginosabiofilms

(2010) Peter Østrup Jensen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Improved Diagnosis of Periprosthetic Joint Infection by Multiplex PCR of Sonication Fluid from Removed Implants

(2010) Y. Achermann et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Colistin‐Tobramycin Combinations Are Superior to Monotherapy Concerning the Killing of BiofilmPseudomonas aeruginosa

(2010) Gloria Herrmann et al.   JOURNAL OF INFECTIOUS DISEASES

Therapeutic ultrasound as treatment for chronic rhinosinusitis: preliminary observations

(2010) D Young et al.   JOURNAL OF LARYNGOLOGY AND OTOLOGY

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

Two-component regulatory systems in Pseudomonas aeruginosa: an intricate network mediating fimbrial and efflux pump gene expression

(2010) Melissa Sivaneson et al.   MOLECULAR MICROBIOLOGY

In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

(2010) Thomas Bjarnsholt et al.   Nature Protocols

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection

(2010) Z. Song et al.   PHYTOMEDICINE

Quorum Sensing and Virulence of Pseudomonas aeruginosa during Lung Infection of Cystic Fibrosis Patients

(2010) Thomas Bjarnsholt et al.   PLoS One

A Biofilm Approach to Detect Bacteria on Removed Spinal Implants

(2010) Marta Fernandez Sampedro et al.   SPINE

Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients

(2010) T. Kohler et al.   THORAX

Sonication is superior to scraping for retrieval of bacteria in biofilm on titanium and steel surfaces in vitro

(2009) Geir Bjerkan et al.   Acta Orthopaedica

Iron chelation directed against biofilms as an adjunct to conventional antibiotics

(2009) D. W. Reid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tobramycin and FDA-Approved Iron Chelators EliminatePseudomonas aeruginosaBiofilms on Cystic Fibrosis Cells

(2009) Sophie Moreau-Marquis et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bacteriophage Cocktail for the Prevention of Biofilm Formation by Pseudomonas aeruginosa on Catheters in an In Vitro Model System

(2009) W. Fu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plectasin Shows Intracellular Activity against Staphylococcus aureus in Human THP-1 Monocytes and in a Mouse Peritonitis Model

(2009) K. S. Brinch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

(2009) MARIA VAN GENNIP et al.   APMIS

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors

(2009) Davide Antoniani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Early Experience with High‐Dosage Daptomycin for Prosthetic Infections

(2009) Francesco G. De Rosa et al.   CLINICAL INFECTIOUS DISEASES

Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter‐Related Infection: 2009 Update by the Infectious Diseases Society of America

(2009) Leonard A. Mermel et al.   CLINICAL INFECTIOUS DISEASES

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

(2009) THOMAS BJARNSHOLT et al.   DERMATOLOGIC SURGERY

Antibacterial surfaces for biomedical devices

(2009) Krasimir Vasilev et al.   Expert Review of Medical Devices

Importance of DNase and alginate lyase for enhancing free and liposome encapsulated aminoglycoside activity against Pseudomonas aeruginosa

(2009) M. Alipour et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhaled medication and inhalation devices for lung disease in patients with cystic fibrosis: A European consensus

(2009) Harry Heijerman et al.   Journal of Cystic Fibrosis

The role of diclofenac sodium in the dimorphic transition in Candida albicans

(2009) Zahra Rashki Ghalehnoo et al.   MICROBIAL PATHOGENESIS

Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

(2009) O. Ciofu et al.   MICROBIOLOGY-SGM

Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

(2009) M. Alhede et al.   MICROBIOLOGY-SGM

A method for growing a biofilm under low shear at the air–liquid interface using the drip flow biofilm reactor

(2009) Darla M Goeres et al.   Nature Protocols

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY

Quality-Controlled Small-Scale Production of a Well-Defined Bacteriophage Cocktail for Use in Human Clinical Trials

(2009) Maya Merabishvili et al.   PLoS One

Pseudomonas aeruginosa PAO1 Preferentially Grows as Aggregates in Liquid Batch Cultures and Disperses upon Starvation

(2009) David Schleheck et al.   PLoS One

Metagenomic Analysis of Respiratory Tract DNA Viral Communities in Cystic Fibrosis and Non-Cystic Fibrosis Individuals

(2009) Dana Willner et al.   PLoS One

The role of natural environments in the evolution of resistance traits in pathogenic bacteria

(2009) J. L. Martinez   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A Meyer

(2008) Kwang-tae CHOI   ACTA PHARMACOLOGICA SINICA

Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa

(2008) M. E. Skindersoe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

(2008) M. Kvist et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Small RNA gene identification and mRNA target predictions in bacteria

(2008) C. Pichon et al.   BIOINFORMATICS

Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy

(2008) Sünje Johanna Pamp et al.   CYTOMETRY PART A

Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial

(2008) Lorenzo Berra et al.   INTENSIVE CARE MEDICINE

Activity of daptomycin on biofilms produced on a plastic support by Staphylococcus spp.

(2008) S. Roveta et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Tolerance of dormant and active cells in Pseudomonas aeruginosa PA01 biofilm to antimicrobial agents

(2008) Jaeeun Kim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Increased mutability of Pseudomonas aeruginosa in biofilms

(2008) K. Driffield et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Involvement of a Novel Efflux System in Biofilm-Specific Resistance to Antibiotics

(2008) L. Zhang et al.   JOURNAL OF BACTERIOLOGY

A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms

(2008) D. G. Davies et al.   JOURNAL OF BACTERIOLOGY

Distribution, Organization, and Ecology of Bacteria in Chronic Wounds

(2008) K. Kirketerp-Moller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience

(2008) C.R. Hansen et al.   Journal of Cystic Fibrosis

Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

(2008) Sünje Johanna Pamp et al.   MOLECULAR MICROBIOLOGY

Good effect of IgY againstPseudomonas aeruginosainfections in cystic fibrosis patients

(2008) Elin Nilsson et al.   PEDIATRIC PULMONOLOGY

The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent

(2008) E. Banin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous oxidative stress produces diversity and adaptability in biofilm communities

(2008) B. R. Boles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial

(2008) Jennifer Broom et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

(2008) Heidi Mulcahy et al.   PLoS Pathogens

agr-Mediated Dispersal of Staphylococcus aureus Biofilms

(2008) Blaise R. Boles et al.   PLoS Pathogens

Quorum sensing inhibitory drugs as next generation antimicrobials: Worth the effort?

(2008) Thomas Bjarnsholt et al.   Current Infectious Disease Reports

Why chronic wounds will not heal: a novel hypothesis

(2007) Thomas Bjarnsholt et al.   WOUND REPAIR AND REGENERATION