Role of Mitophagy in Regulating Intestinal Oxidative Damage

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study

(2023) Adam S Faye et al.   GUT

Mitochondrial fusion, fission and mitophagy in cardiac diseases: challenges and therapeutic opportunities

(2022) Débora da Luz Scheffer et al.   ANTIOXIDANTS & REDOX SIGNALING

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy

(2022) Kun Liu et al.   Cell Death & Disease

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

(2022) Anqi Li et al.   Cell Death & Disease

Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn’s Disease

(2022) Jinguo Liu et al.   Frontiers in Pharmacology

Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway

(2022) Chen Cai et al.   Redox Biology

Structures of human dual oxidase 1 complex in low-calcium and high-calcium states

(2021) Jing-Xiang Wu et al.   Nature Communications

Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner

(2021) Cheng Zhang et al.   Cell Death & Disease

Novel Optineurin Frameshift Insertion in a Family With Frontotemporal Dementia and Parkinsonism Without Amyotrophic Lateral Sclerosis

(2021) Jacqueline Dominguez et al.   Frontiers in Neurology

Mitophagy and Oxidative Stress: The Role of Aging

(2021) Anna De Gaetano et al.   Antioxidants

Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review

(2021) Cheng-long Zhu et al.   Frontiers in Cell and Developmental Biology

Probiotics Improve Eating Disorders in Mandarin Fish (Siniperca chuatsi) Induced by a Pellet Feed Diet via Stimulating Immunity and Regulating Gut Microbiota

(2021) Xiaoli Chen et al.   Microorganisms

Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling

(2021) Yanan Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

How to build a ribosome from RNA fragments in Chlamydomonas mitochondria

(2021) Florent Waltz et al.   Nature Communications

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

(2021) Michael J. Munson et al.   Nature Communications

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

(2021) Yuxian Guo et al.   Nature Communications

AMPK-PINK1/Parkin Mediated Mitophagy Is Necessary for Alleviating Oxidative Stress-Induced Intestinal Epithelial Barrier Damage and Mitochondrial Energy Metabolism Dysfunction in IPEC-J2

(2021) Shuting Cao et al.   Antioxidants

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis

(2020) Dakota N Jackson et al.   GUT

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence

(2020) Sevana Khaloian et al.   GUT

Impact of in ovo administered pioneer colonizers on intestinal proteome on day of hatch

(2020) K.M. Wilson et al.   POULTRY SCIENCE

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

(2020) Alessandro Luciani et al.   Nature Communications

Prenatal Hypoxia and Placental Oxidative Stress: Insights from Animal Models to Clinical Evidences

(2020) Serena Silvestro et al.   Antioxidants

The four epidemiological stages in the global evolution of inflammatory bowel disease

(2020) Gilaad G. Kaplan et al.   Nature Reviews Gastroenterology & Hepatology

Isoproterenol-Induced Permeability Transition Pore-Related Dysfunction of Heart Mitochondria Is Attenuated by Astaxanthin

(2020) Roman Krestinin et al.   Biomedicines

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells

(2020) Amy M. Ehrlich et al.   BMC MICROBIOLOGY

Phytic Acid Decreases Oxidative Stress and Intestinal Lesions Induced by Fumonisin B1 and Deoxynivalenol in Intestinal Explants of Pigs

(2019) Elisângela da Silva et al.   Toxins

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

(2019) Enza Vernucci et al.   Oxidative Medicine and Cellular Longevity

BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

(2019) Meng-Hsuan Cheng et al.   Oxidative Medicine and Cellular Longevity

Proteomics highlights common and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn’s disease

(2019) Nicolas Pierre et al.   Journal of Crohns & Colitis

Outstanding Questions in Mitophagy: What We Do and Do Not Know

(2019) Lambert Montava-Garriga et al.   JOURNAL OF MOLECULAR BIOLOGY

The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics

(2019) Debasna P. Panigrahi et al.   SEMINARS IN CANCER BIOLOGY

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

(2019) Mai Tram Vo et al.   Nature Communications

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

(2019) Mu Li et al.   Advanced Science

Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

(2019) Dong Hun Lee et al.   Cell Communication and Signaling

SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells

(2019) Danyang Liang et al.   BIOCHIMIE

Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway

(2019) Shuting Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

(2018) Hao Zhou et al.   CELL DEATH AND DIFFERENTIATION

Protective effect of low molecular-weight seleno-aminopolysaccharides against H 2 O 2 -induecd oxidative stress in intestinal epithelial cells

(2018) Zheng-Shun Wen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets1

(2018) Shuting Cao et al.   JOURNAL OF ANIMAL SCIENCE

Effects of a Saccharomyces cerevisiae fermentation product in receiving diets of newly weaned beef steers. II. Digestibility and response to a vaccination challenge1

(2018) Erin L Deters et al.   JOURNAL OF ANIMAL SCIENCE

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

(2018) Aspen T Reese et al.   eLife

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer

(2018) Robert Weil et al.   Frontiers in Immunology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Lung colonization by Aspergillus fumigatus is controlled by ZNF77

(2018) Sara Gago et al.   Nature Communications

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

(2018) Prakash P. Praharaj et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The protective effects of fecal microbiota transplantation in an experimental model of necrotizing enterocolitis

(2018) Christian Prado et al.   JOURNAL OF PEDIATRIC SURGERY

Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation

(2018) Chu-Tian Mai et al.   MOLECULAR IMMUNOLOGY

The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations

(2018) Nicola Laforgia et al.   Oxidative Medicine and Cellular Longevity

A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function

(2018) Dandan Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation

(2017) Seong-Jun Kim et al.   HEPATOLOGY

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

(2017) Subra Kugathasan et al.   LANCET

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

(2017) Tian Tian et al.   Oxidative Medicine and Cellular Longevity

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

(2017) Bin Xiao et al.   Cell Death & Disease

Antioxidant Properties of Probiotic Bacteria

(2017) Yang Wang et al.   Nutrients

Effects of dietary supplementation with epidermal growth factor-expressing Saccharomyces cerevisiae on duodenal development in weaned piglets

(2016) Shujin Wang et al.   BRITISH JOURNAL OF NUTRITION

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

(2016) V E Kagan et al.   CELL DEATH AND DIFFERENTIATION

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

(2016) Nan Yao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis

(2016) Yongping Zhang et al.   MOLECULAR CELL

Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells

(2016) Yi Zou et al.   Oxidative Medicine and Cellular Longevity

Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation

(2016) Jacob D. Aguirre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control

(2016) Na Zhuang et al.   Cell Death & Disease

Toxicity assessment of hydrogen peroxide on Toll-like receptor system, apoptosis, and mitochondrial respiration in piglets and IPEC-J2 cells

(2016) Jie Yin et al.   Oncotarget

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

(2015) Cathrin Meissner et al.   Autophagy

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells

(2015) Ning Jiao et al.   JOURNAL OF NUTRITION

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation

(2015) Qiao Zhang et al.   NATURE IMMUNOLOGY

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells

(2014) Soumita Das et al.   FASEB JOURNAL

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Telmisartan Attenuates Colon Inflammation, Oxidative Perturbations and Apoptosis in a Rat Model of Experimental Inflammatory Bowel Disease

(2014) Hany H. Arab et al.   PLoS One

Activation of JNK Contributes to Evodiamine-Induced Apoptosis and G2/M Arrest in Human Colorectal Carcinoma Cells: A Structure-Activity Study of Evodiamine

(2014) Chih-Chiang Chien et al.   PLoS One

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

(2013) Qingjing Wang et al.   BMC GASTROENTEROLOGY

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

(2013) Amarjargal Dashdorj et al.   BMC Medicine

The dynamics of gut-associated microbial communities during inflammation

(2013) Sebastian E Winter et al.   EMBO REPORTS

Chemistry meets biology in colitis-associated carcinogenesis

(2013) A. Mangerich et al.   FREE RADICAL RESEARCH

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Concepts of oxidative stress and antioxidant defense in Crohn’s disease

(2013) Mohammed A Alzoghaibi   WORLD JOURNAL OF GASTROENTEROLOGY

Selective escape of proteins from the mitochondria during mitophagy

(2013) Shotaro Saita et al.   Nature Communications

Antioxidant effects of Lactobacillus plantarum via activation of transcription factor Nrf2

(2013) Dawei Gao et al.   Food & Function

Oxidative stress markers in intestinal mucosa of Tunisian inflammatory bowel disease patients

(2013) Dorra Bouzid et al.   Saudi Journal of Gastroenterology

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

(2012) Arjun Saha et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Hormesis in PancreaticβCells: Does Uncoupling Protein 2 Play a Role?

(2012) Ning Li et al.   Oxidative Medicine and Cellular Longevity

Correlation between the destruction of tight junction by patulin treatment and increase of phosphorylation of ZO-1 in Caco-2 human colon cancer cells

(2011) Tomoko Kawauchiya et al.   TOXICOLOGY LETTERS

Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore

(2010) Melissa N. Quinsay et al.   Autophagy

Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease

(2010) A. Szaflarska-Poplawska et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Tight junctions as targets of infectious agents

(2008) Julian A. Guttman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

(2008) Q. Lan et al.   BLOOD

Phosphorylation of Tyr-398 and Tyr-402 in Occludin Prevents Its Interaction with ZO-1 and Destabilizes Its Assembly at the Tight Junctions

(2008) Bertha C. Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk of tight junction components with signaling pathways

(2007) Lorenza González-Mariscal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES