Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation
Authors
Keywords
-
Journal
Frontiers in Bioengineering and Biotechnology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2023-02-16
DOI
10.3389/fbioe.2023.1138596
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges
- (2022) Eman A. Taha et al. JOURNAL OF CONTROLLED RELEASE
- Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia
- (2022) Earl Sands et al. Nature Communications
- Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through
- (2022) Narmatha Gurumoorthy et al. Biomedicines
- The Effect of Rapamycin and Ibrutinib on Antibody Responses to Adeno-Associated Virus Vector-Mediated Gene Transfer
- (2022) Zhiquan Xiang et al. HUMAN GENE THERAPY
- High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA
- (2022) Soyoung A. Oh et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing
- (2022) Alexander Dimitri et al. Molecular Cancer
- Investigation of Cas9 antibodies in the human eye
- (2022) Marcus A. Toral et al. Nature Communications
- Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges
- (2022) Misganaw Asmamaw Mengstie Frontiers in Bioengineering and Biotechnology
- Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans
- (2022) Xin-Zi Emily Tang et al. NATURE MEDICINE
- Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification
- (2022) Xiaoting Shen et al. CRISPR Journal
- Immune Responses to Gene Editing by Viral and Non-Viral Delivery Vectors Used in Retinal Gene Therapy
- (2022) Duohao Ren et al. Pharmaceutics
- Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect
- (2021) Yu-Fan Chuang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A Double-Blind, Randomized, Placebo-Controlled Phase 1 Study of Ad26.ZIKV.001, an Ad26-Vectored Anti–Zika Virus Vaccine
- (2021) Nadine C. Salisch et al. ANNALS OF INTERNAL MEDICINE
- Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?
- (2021) Dimitrios Laurin Wagner et al. GENE THERAPY
- Immunogenicity of CAR T cells in cancer therapy
- (2021) Dimitrios L. Wagner et al. Nature Reviews Clinical Oncology
- Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease
- (2021) Naoya Uchida et al. Molecular Therapy-Methods & Clinical Development
- In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
- (2021) Kiran Musunuru et al. NATURE
- Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning
- (2021) Anna Z. Wec et al. Frontiers in Immunology
- Genome Editing in Bacteria: CRISPR-Cas and Beyond
- (2021) Ruben D. Arroyo-Olarte et al. Microorganisms
- Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
- (2021) Mohammadsharif Tabebordbar et al. CELL
- AAV integration in human hepatocytes
- (2021) Dhwanil A. Dalwadi et al. MOLECULAR THERAPY
- CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
- (2021) Julian D. Gillmore et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives
- (2021) Wendy Dong et al. Viruses-Basel
- Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
- (2021) Vijaya L. Simhadri et al. Nature Communications
- ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia
- (2021) Petr O. Ilyinskii et al. Molecular Therapy-Methods & Clinical Development
- The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes
- (2021) Shen Dong et al. JCI Insight
- COVID-19 Vaccines: Adenoviral Vectors
- (2021) Catherine Jacob-Dolan et al. Annual Review of Medicine
- Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes
- (2021) Adam Ramzy et al. Cell Stem Cell
- Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses
- (2021) Vijaya L. Simhadri et al. GENE THERAPY
- Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays
- (2021) Axel Ducret et al. mAbs
- Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice
- (2021) Eriya Kenjo et al. Nature Communications
- Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo
- (2021) Raed Ibraheim et al. Nature Communications
- Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
- (2021) Chady H. Hakim et al. Nature Communications
- T Cell Epitope Predictions
- (2020) Bjoern Peters et al. Annual Review of Immunology
- Encouraging and Unsettling Findings in Long-Term Follow-up of AAV Gene Transfer
- (2020) Roland W. Herzog MOLECULAR THERAPY
- Immune Responses to Viral Gene Therapy Vectors
- (2020) Jamie L. Shirley et al. MOLECULAR THERAPY
- AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer
- (2020) Helena Costa Verdera et al. MOLECULAR THERAPY
- CRISPR-engineered T cells in patients with refractory cancer
- (2020) Edward A. Stadtmauer et al. SCIENCE
- CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular Programming
- (2020) Matthew Pandelakis et al. Cell Systems
- A mutation-independent CRISPR-Cas9–mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency
- (2020) Lili Wang et al. Science Advances
- Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems
- (2020) Alan R. Davidson et al. Annual Review of Biochemistry
- AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9
- (2020) Ang Li et al. MOLECULAR THERAPY
- Immunity to Cas9 as an Obstacle to Persistent Genome Editing
- (2020) Veronica Gough et al. MOLECULAR THERAPY
- Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer
- (2020) You Lu et al. NATURE MEDICINE
- Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies
- (2020) Takashi Kei Kishimoto Frontiers in Immunology
- High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells
- (2020) Marcella Brescia et al. Cells
- Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny
- (2020) Francesca Tasca et al. Cells
- Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults
- (2020) Mark J. Mulligan et al. NATURE
- B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin
- (2020) Moanaro Biswas et al. Frontiers in Immunology
- CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future
- (2020) Fathema Uddin et al. Frontiers in Oncology
- Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial
- (2020) Lorenz Leitner et al. LANCET INFECTIOUS DISEASES
- Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
- (2020) Edward E. Walsh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome Editing for CNS Disorders
- (2020) Fábio Duarte et al. Frontiers in Neuroscience
- The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations
- (2020) Lauren V. Terry et al. Frontiers in Immunology
- Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study
- (2020) Lindsey R Baden et al. Lancet HIV
- Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A
- (2020) Brian R. Long et al. MOLECULAR THERAPY
- CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
- (2020) Haydar Frangoul et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficient viral delivery of Cas9 into human safe harbor
- (2020) Hideki Hayashi et al. Scientific Reports
- Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
- (2020) Xiaoxia Shi et al. Molecular Therapy-Methods & Clinical Development
- Safety and immunogenicity of a two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): a randomised, observer-blind, participant-blind, placebo-controlled, phase 2 trial
- (2020) Andrew J Pollard et al. LANCET INFECTIOUS DISEASES
- Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
- (2019) Morgan L. Maeder et al. NATURE MEDICINE
- SpCas9-expression by tumor cells can cause T cell-dependent tumor rejection in immunocompetent mice
- (2019) Reham Ajina et al. OncoImmunology
- Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene
- (2019) Céline Bouquet et al. JAMA Ophthalmology
- Identification of preexisting adaptive immunity to Cas9 proteins in humans
- (2019) Carsten T. Charlesworth et al. NATURE MEDICINE
- Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
- (2019) Christopher E. Nelson et al. NATURE MEDICINE
- Gene Therapy for Inherited Retinal Degeneration
- (2019) Amirmohsen Arbabi et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing
- (2019) Danny Wilbie et al. ACCOUNTS OF CHEMICAL RESEARCH
- Design and construction of a recombinant lentiviral vector with specific tropism to human epidermal growth factor‐overexpressed cancer cells: developing a new retargeting system for lentivirus vectors
- (2019) Sima Ebrahimabadi et al. JOURNAL OF GENE MEDICINE
- Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
- (2019) Shayesteh R. Ferdosi et al. Nature Communications
- Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy
- (2019) Ana M. Moreno et al. Nature Biomedical Engineering
- CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia
- (2019) Lei Xu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunogenicity of Cas9 Protein
- (2019) Aditi Mehta et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Weakly immunogenic CRISPR therapies
- (2019) Eric A. Wilson et al. Nature Biomedical Engineering
- Gene editing prospects for treating inherited retinal diseases
- (2019) Daniela Benati et al. JOURNAL OF MEDICAL GENETICS
- Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
- (2019) Kira S. Makarova et al. NATURE REVIEWS MICROBIOLOGY
- 2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 – Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)
- (2019) Steven Piccoli et al. Bioanalysis
- The Biology of CRISPR-Cas: Backward and Forward
- (2018) Frank Hille et al. CELL
- Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9
- (2018) Calvin J. Stephens et al. GENE THERAPY
- CRISPR RNAs trigger innate immune responses in human cells
- (2018) Sojung Kim et al. GENOME RESEARCH
- Recent progress and considerations for AAV gene therapies targeting the central nervous system
- (2018) Erik Allen Lykken et al. Journal of Neurodevelopmental Disorders
- The CRISPR tool kit for genome editing and beyond
- (2018) Mazhar Adli Nature Communications
- A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
- (2018) Jonathan D. Finn et al. Cell Reports
- Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population
- (2018) Vijaya L. Simhadri et al. Molecular Therapy-Methods & Clinical Development
- Spatiotemporal control of zebrafish (Danio rerio) gene expression using a light-activated CRISPR activation system
- (2018) Rizka Rahmana Putri et al. GENE
- Adapted Bacteriophages for Treating Urinary Tract Infections
- (2018) Aleksandre Ujmajuridze et al. Frontiers in Microbiology
- High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population
- (2018) Dimitrios L. Wagner et al. NATURE MEDICINE
- Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens
- (2018) Ashrafali M. Ismail et al. Emerging Microbes & Infections
- A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing
- (2018) Ang Li et al. Molecular Therapy-Methods & Clinical Development
- Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
- (2017) Stephen Russell et al. LANCET
- Non-viral strategies for ocular gene delivery
- (2017) Ana V. Oliveira et al. Materials Science & Engineering C-Materials for Biological Applications
- CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10
- (2017) Guo-Xiang Ruan et al. MOLECULAR THERAPY
- Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
- (2017) Justin Eyquem et al. NATURE
- Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
- (2017) Benjamin H Weinberg et al. NATURE BIOTECHNOLOGY
- Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy
- (2017) Jerry R. Mendell et al. NEW ENGLAND JOURNAL OF MEDICINE
- Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency
- (2017) Roberto Calcedo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunity to CRISPR Cas9 and Cas12a therapeutics
- (2017) Wei Leong Chew Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
- (2017) Serif Senturk et al. Nature Communications
- Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
- (2017) Dirk A. Kleinjan et al. Nature Communications
- Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial
- (2017) Lorenz Leitner et al. BMC Urology
- Safety of Intradiaphragmatic Delivery of Adeno-Associated Virus-Mediated Alpha-Glucosidase (rAAV1-CMV-hGAA) Gene Therapy in Children Affected by Pompe Disease
- (2017) Manuela Corti et al. Human Gene Therapy Clinical Development
- Complexity of immune responses to AAV transgene products – Example of factor IX
- (2017) Roland W. Herzog CELLULAR IMMUNOLOGY
- Long-Term Retrospective Analysis of Gene Therapy with Alipogene Tiparvovec and Its Effect on Lipoprotein Lipase Deficiency-Induced Pancreatitis
- (2016) Daniel Gaudet et al. HUMAN GENE THERAPY
- Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice
- (2016) Carmen Agustín-Pavón et al. Molecular Neurodegeneration
- Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients
- (2016) Irene Gil-Farina et al. MOLECULAR THERAPY
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
- (2016) Hao Yin et al. NATURE BIOTECHNOLOGY
- Complex transcriptional modulation with orthogonal and inducible dCas9 regulators
- (2016) Yuchen Gao et al. NATURE METHODS
- A multifunctional AAV–CRISPR–Cas9 and its host response
- (2016) Wei Leong Chew et al. NATURE METHODS
- Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management
- (2015) Steven Y. C. Tong et al. CLINICAL MICROBIOLOGY REVIEWS
- Adenovirus-Mediated Somatic Genome Editing ofPtenby CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
- (2015) Dan Wang et al. HUMAN GENE THERAPY
- Inducible in vivo genome editing with CRISPR-Cas9
- (2015) Lukas E Dow et al. NATURE BIOTECHNOLOGY
- Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
- (2015) James E Dahlman et al. NATURE BIOTECHNOLOGY
- Highly efficient Cas9-mediated transcriptional programming
- (2015) Alejandro Chavez et al. NATURE METHODS
- Cas9 gRNA engineering for genome editing, activation and repression
- (2015) Samira Kiani et al. NATURE METHODS
- TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+T cell epitopes
- (2015) Diego Chowell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR transcriptional repression devices and layered circuits in mammalian cells
- (2014) Samira Kiani et al. NATURE METHODS
- The immune epitope database (IEDB) 3.0
- (2014) Randi Vita et al. NUCLEIC ACIDS RESEARCH
- Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA
- (2014) E. P. Thi et al. Science Translational Medicine
- Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside
- (2014) Valerie Ferreira et al. Frontiers in Immunology
- Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia
- (2014) Debalina Sarkar et al. Molecular Therapy-Methods & Clinical Development
- AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction
- (2013) Lluis Samaranch et al. MOLECULAR THERAPY
- Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
- (2013) Evan W Newell et al. NATURE BIOTECHNOLOGY
- T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
- (2013) M. V. Maus et al. Cancer Immunology Research
- Measles Virus Glycoprotein-Pseudotyped Lentiviral Vectors Are Highly Superior to Vesicular Stomatitis Virus G Pseudotypes for Genetic Modification of Monocyte-Derived Dendritic Cells
- (2012) J.- M. Humbert et al. JOURNAL OF VIROLOGY
- Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses
- (2012) Agnieszka Ciesielska et al. MOLECULAR THERAPY
- Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
- (2012) M. Garriga-Canut et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia
- (2011) C Li et al. GENE THERAPY
- Dystrophin Immunity in Duchenne's Muscular Dystrophy
- (2010) Jerry R. Mendell et al. NEW ENGLAND JOURNAL OF MEDICINE
- In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance
- (2009) A. Annoni et al. BLOOD
- Transduction of Nonhuman Primate Brain with Adeno-Associated Virus Serotype 1: Vector Trafficking and Immune Response
- (2009) Piotr Hadaczek et al. HUMAN GENE THERAPY
- Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses
- (2009) Roberto Calcedo et al. JOURNAL OF INFECTIOUS DISEASES
- Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
- (2009) Albert M Maguire et al. LANCET
- Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration
- (2009) Francesca Simonelli et al. MOLECULAR THERAPY
- Expanded Repertoire of AAV Vector Serotypes Mediate Unique Patterns of Transduction in Mouse Brain
- (2008) Cassia N Cearley et al. MOLECULAR THERAPY
- Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection
- (2008) Carmela Zincarelli et al. MOLECULAR THERAPY
- Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
- (2008) Kevin D Foust et al. NATURE BIOTECHNOLOGY
- Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis
- (2008) James W.B. Bainbridge et al. NEW ENGLAND JOURNAL OF MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now