AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9

Authors

Keywords

gene therapy, SaCas9, AAV-CRISPR, CD8+ T cell, immune response, somatic genome editing, hepatocytes, adeno-associated virus, pre-existing immunity, liver

Journal

MOLECULAR THERAPY

Volume -, Issue -, Pages -

Publisher

Elsevier BV

Online

2020-04-20

DOI

10.1016/j.ymthe.2020.04.017

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