Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
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Title
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
Authors
Keywords
directed evolution, AAV capsid engineering, muscle gene therapy, Duchenne muscular dystrophy, X-linked myotubular myopathy, integrin heterodimers, non-human primates, MyoAAV
Journal
CELL
Volume 184, Issue 19, Pages 4919-4938.e22
Publisher
Elsevier BV
Online
2021-09-09
DOI
10.1016/j.cell.2021.08.028
References
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