The Role of Mitophagy in Skeletal Muscle Damage and Regeneration

Muscle Delivery of Mitochondria-Targeted Drugs for the Treatment of Sarcopenia: Rationale and Perspectives

(2022) Francesco Bellanti et al.   Pharmaceutics

Optimizing mechanical stretching protocols for hypertrophic and anti-apoptotic responses in cardiomyocyte-like H9C2 cells

(2021) Evangelos Zevolis et al.   MOLECULAR BIOLOGY REPORTS

Mitochondrial network remodeling: an important feature of myogenesis and skeletal muscle regeneration

(2021) Fasih Ahmad Rahman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging

(2021) Jean-Philippe Leduc-Gaudet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of tissue remodelling, inflammation- and angiogenesis-related factors after eccentric exercise in humans

(2021) Anastassios Philippou et al.   MOLECULAR BIOLOGY REPORTS

Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling

(2021) Fasih Ahmad Rahman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle

(2020) Matteo Giovarelli et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Divergent Roles of Inflammation in Skeletal Muscle Recovery From Injury

(2020) Emily E. Howard et al.   Frontiers in Physiology

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening

(2020) Chia-Yu Chang et al.   MOLECULES

Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle

(2020) Fasih Ahmad Rahman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation

(2020) Maude Dulac et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!

(2020) Bénédicte Chazaud   TRENDS IN IMMUNOLOGY

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

Mitochondrial Function in Muscle Stem Cell Fates

(2020) Debasmita Bhattacharya et al.   Frontiers in Cell and Developmental Biology

Role of damage and management in muscle hypertrophy: Different behaviors of muscle stem cells in regeneration and hypertrophy

(2020) So-ichiro Fukada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass

(2020) Vanina Romanello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PAI-1, the Plasminogen System, and Skeletal Muscle

(2020) Fasih Ahmad Rahman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

(2020) William P. Lafuse et al.   Cells

Exercise intensity independently modulates thermal behavior during exercise recovery, but not during exercise

(2019) Nicole T. Vargas et al.   JOURNAL OF APPLIED PHYSIOLOGY

Parkin overexpression protects from aging-related loss of muscle mass and strength

(2019) Jean-Philippe Leduc-Gaudet et al.   JOURNAL OF PHYSIOLOGY-LONDON

Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training

(2019) Yoshitake Cho et al.   Molecular Metabolism

Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation

(2019) Brittany L. Baechler et al.   Autophagy

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

(2019) Mark A. Lampert et al.   Autophagy

Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells

(2019) Matthew M. Robinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy, Apoptosis, and Mitochondria: Molecular Integration and Physiological Relevance in Skeletal Muscle

(2019) Darin Bloemberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Exercise-Induced Mitophagy in Skeletal Muscle and Heart

(2019) Yuntian Guan et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Mitochondrial Dynamics: Biogenesis, Fission, Fusion, and Mitophagy in the Regulation of Stem Cell Behaviors

(2019) Wenyan Fu et al.   Stem Cells International

Eccentric Muscle Contractions: Risks and Benefits

(2019) Stéphanie Hody et al.   Frontiers in Physiology

Looking beyond PGC-1α: Emerging regulators of exercise-induced skeletal muscle mitochondrial biogenesis and their activation by dietary compounds

(2019) Hashim Islam et al.   Applied Physiology Nutrition and Metabolism

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice

(2019) Anna S. Nichenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Loss of Parkin Impairs Mitochondrial Function and Leads to Muscle Atrophy

(2018) Nesibe Peker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner

(2018) Avigail T. Erlich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases

(2018) Yan Zhao et al.   INFLAMMATION

Protective role of Parkin in skeletal muscle contractile and mitochondrial function

(2018) Gilles Gouspillou et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hormonal Responses after Exercise-induced Muscle Damage in Healthy Humans

(2018) Anastassios Philippou et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity

(2018) Tingting Fu et al.   Cell Reports

The Role of Mitophagy in Innate Immunity

(2018) Ilias Gkikas et al.   Frontiers in Immunology

Mitophagy-driven metabolic switch reprograms stem cell fate

(2018) Prajna Paramita Naik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adult Skeletal Muscle Deletion of Mitofusin 1 and 2 Impedes Exercise Performance and Training Capacity

(2018) Margaret B. Bell et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mechanisms Orchestrating Mitochondrial Dynamics for Energy Homeostasis

(2018) Seungyoon B. Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

(2018) Anna Picca et al.   Nature Reviews Cardiology

Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer

(2018) Xilan Yu et al.   Frontiers in Genetics

Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria

(2018) Joshua C. Drake et al.   CELL CYCLE

The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration

(2018) David Thomson   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle

(2018) Timothy M. Moore et al.   Molecular Metabolism

The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis

(2017) Felipe Damas et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Lack of Activation of Mitophagy during Endurance Exercise in Human

(2017) CÉLINE SCHWALM et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

(2017) Konstantinos Palikaras et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

(2017) David Sebastián et al.   TRENDS IN MOLECULAR MEDICINE

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

(2017) Brianada Koentjoro et al.   Scientific Reports

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

(2017) Evandro F. Fang et al.   Scientific Reports

Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling

(2016) Anna S. Nichenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

(2016) Antoine H. Chaanine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle

(2016) Yoshitake Cho et al.   FASEB JOURNAL

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

(2016) Nathan P. Young et al.   GENES & DEVELOPMENT

BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

(2016) Tongmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

Comparative Study of Injury Models for Studying Muscle Regeneration in Mice

(2016) David Hardy et al.   PLoS One

Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis

(2015) Hao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle

(2015) Yu Kitaoka et al.   Applied Physiology Nutrition and Metabolism

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

(2015) Hanne Hoitzing et al.   BIOESSAYS

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

(2015) Serge Ducommun et al.   CELLULAR SIGNALLING

Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments

(2015) Pabalu P. Karunadharma et al.   FASEB JOURNAL

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation

(2015) Céline Schwalm et al.   FASEB JOURNAL

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

(2015) T Touvier et al.   Cell Death & Disease

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

Mitochondria in lung biology and pathology: more than just a powerhouse

(2014) Paul T. Schumacker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity

(2014) Francesca Lo Verso et al.   Autophagy

Autophagy is required and protects against apoptosis during myoblast differentiation

(2014) Elliott M. McMillan et al.   BIOCHEMICAL JOURNAL

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Downregulation of E3 Ubiquitin Ligases and Mitophagy-Related Genes in Skeletal Muscle of Physically Inactive, Frail Older Women: A Cross-Sectional Comparison

(2014) M. J. Drummond et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN

(2014) Somak Das et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial biogenesis in cardiac pathophysiology

(2014) Stéphanie Rimbaud et al.   Pharmacological Reports

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis

(2014) S Baldelli et al.   Cell Death & Disease

Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation

(2013) Boa Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

(2013) Xinde Zheng et al.   CELL RESEARCH

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle

(2013) Brian G. Drew et al.   DIABETES

Weakness, SR function and stress in gastrocnemius muscles of aged male rats

(2013) David W. Russ et al.   EXPERIMENTAL GERONTOLOGY

Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

(2013) Pura Muñoz-Cánoves et al.   FEBS Journal

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells

(2013) Yoshitake Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lengthening our perspective: Morphological, cellular, and molecular responses to eccentric exercise

(2013) Robert D. Hyldahl et al.   MUSCLE & NERVE

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission

(2013) S. Koirala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

IL-10 Triggers Changes in Macrophage Phenotype That Promote Muscle Growth and Regeneration

(2012) B. Deng et al.   JOURNAL OF IMMUNOLOGY

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

(2012) A. Orsi et al.   MOLECULAR BIOLOGY OF THE CELL

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

PGC-1α is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle

(2012) Glenn C. Rowe et al.   PLoS One

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity

(2012) Mathilde Latil et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

PKB signaling and atrogene expression in skeletal muscle of aged mice

(2011) Megan Gaugler et al.   JOURNAL OF APPLIED PHYSIOLOGY

PGC-1-related Coactivator (PRC), a Sensor of Metabolic Stress, Orchestrates a Redox-sensitive Program of Inflammatory Gene Expression

(2011) Natalie Gleyzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity

(2010) Christoph Zechner et al.   Cell Metabolism

PGC-1 Coactivators in Cardiac Development and Disease

(2010) Glenn C. Rowe et al.   CIRCULATION RESEARCH

Mitochondrial Biogenesis and Fragmentation as Regulators of Muscle Protein Degradation

(2010) Vanina Romanello et al.   CURRENT HYPERTENSION REPORTS

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα

(2010) Di Shao et al.   MITOCHONDRION

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Neuromuscular dysfunction with the experimental arm acting as its own reference following eccentric and isometric exercise

(2010) Anastassios Philippou et al.   SOMATOSENSORY AND MOTOR RESEARCH

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

(2009) Melanie Schwarten et al.   Autophagy

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Systemic cytokine response following exercise-induced muscle damage in humans

(2009) Anastassios Philippou et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Age-related changes of cell death pathways in rat extraocular muscle

(2009) Colleen A. McMullen et al.   EXPERIMENTAL GERONTOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy in Yeast Occurs through a Selective Mechanism

(2008) Tomotake Kanki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal myopathies: An excessive build-up in autophagosomes is too much to handle

(2008) May Christine Malicdan et al.   NEUROMUSCULAR DISORDERS