STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

(2022) Can Gan et al.   Frontiers in Immunology

Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site

(2021) Yao Wang et al.   Cell Death & Disease

YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

(2021) Dan Wang et al.   Nature Communications

Epidemiology of Alcohol-Associated Liver Disease

(2021) Sen Han et al.   Clinics in Liver Disease

Role of the Inflammasome in Liver Disease

(2021) Marcelle de Carvalho Ribeiro et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease

(2021) Qiuyu Cai et al.   Frontiers in Pharmacology

Metabolic Reprogramming of Liver Fibrosis

(2021) M. Eugenia Delgado et al.   Cells

Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis

(2021) Ping Sun et al.   Cellular and Molecular Gastroenterology and Hepatology

Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis

(2020) Jinhang Gao et al.   JOURNAL OF HEPATOLOGY

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Metabolites released from apoptotic cells act as tissue messengers

(2020) Christopher B. Medina et al.   NATURE

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

(2020) Susanne Gaul et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic Steatohepatitis Promoting Kinases

(2020) Samar H. Ibrahim et al.   SEMINARS IN LIVER DISEASE

Induction of in vitro Metabolic Zonation in Primary Hepatocytes Requires Both Near-Physiological Oxygen Concentration and Flux

(2020) Benedikt Scheidecker et al.   Frontiers in Bioengineering and Biotechnology

Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling

(2020) Jinhang Gao et al.   HEPATOLOGY

Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5′ and 3′ flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial fashion

(2019) Mária Csumita et al.   NUCLEIC ACIDS RESEARCH

Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

(2019) Olga Khomich et al.   Cells

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

NLRP3 inflammasome activation in hepatic stellate cells induces murine liver fibrosis

(2018) Maria Eugenia Inzaugarat et al.   HEPATOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis

(2016) Takaya Shirato et al.   ARCHIVES OF TOXICOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

NET23/STING Promotes Chromatin Compaction from the Nuclear Envelope

(2014) Poonam Malik et al.   PLoS One

Innate immunity and cell death in alcoholic liver disease: Role of cytochrome P4502E1

(2014) Mark A. Barnes et al.   Redox Biology

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver

(2011) Laetitia Knockaert et al.   LABORATORY INVESTIGATION