Induction of in vitro Metabolic Zonation in Primary Hepatocytes Requires Both Near-Physiological Oxygen Concentration and Flux

Investigation of the hepatic respiration and liver zonation on rat hepatocytes using an integrated oxygen biosensor in a microscale device

(2019) Satomi Matsumoto et al.   BIOTECHNOLOGY PROGRESS

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

(2018) Javier Garcia-Bermudez et al.   NATURE CELL BIOLOGY

Glucagon contributes to liver zonation

(2018) Xiping Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway

(2018) Zoë D. Burke et al.   Scientific Reports

Ischemia-reperfusion injury and the risk of hepatocellular carcinoma recurrence after deceased donor liver transplantation

(2018) Michał Grąt et al.   Scientific Reports

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

(2018) Linda Lorenz et al.   NATURE

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

(2018) Keren Bahar Halpern et al.   NATURE BIOTECHNOLOGY

Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research

(2017) Trenton L. Place et al.   FREE RADICAL BIOLOGY AND MEDICINE

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture

(2017) Ren Guo et al.   Scientific Reports

Metabolic zonation of the liver: The oxygen gradient revisited

(2017) Thomas Kietzmann   Redox Biology

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

(2016) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

PharmGKB summary

(2015) Liudmila L. Mazaleuskaya et al.   Pharmacogenetics and Genomics

The importance of physiological oxygen concentrations in the sandwich cultures of rat hepatocytes on gas-permeable membranes

(2014) Wenjin Xiao et al.   BIOTECHNOLOGY PROGRESS

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis

(2014) Carmen Chak-Lui Wong et al.   PLoS One

Nuclear PKM2 regulates the Warburg effect

(2013) Weiwei Yang et al.   CELL CYCLE

Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2

(2013) Mohd Iqbal et al.   Molecular Cancer

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection

(2010) Ian P. Newton et al.   MOLECULAR BIOLOGY OF THE CELL

Urea cycle gene expression is suppressed by PFOA treatment in rats

(2010) M.W. Walters et al.   TOXICOLOGY LETTERS

Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry

(2009) Tomoyoshi Soga et al.   ANALYTICAL CHEMISTRY

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

(2009) S. Kidambi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

(2008) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO