Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling

Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice

(2020) Yan Y. Sanders et al.   JCI Insight

Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis

(2020) Feiye Zhou et al.   Cell Death & Disease

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

(2019) Moira B. Hilscher et al.   GASTROENTEROLOGY

Intercellular Communication between Hepatic Cells in Liver Diseases

(2019) Keisaku Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH

(2019) Qianqian Guo et al.   JOURNAL OF HEPATOLOGY

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation

(2018) Ryan Raisner et al.   Cell Reports

Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages

(2018) Brett McGettigan et al.   HEPATOLOGY

Hepatic microcirculation and mechanisms of portal hypertension

(2018) Jordi Gracia-Sancho et al.   Nature Reviews Gastroenterology & Hepatology

The portal hypertension syndrome: etiology, classification, relevance, and animal models

(2017) Jaime Bosch et al.   Hepatology International

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Liver Sinusoidal Endothelial Cell: An Update

(2017) Ana Maretti-Mira et al.   SEMINARS IN LIVER DISEASE

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

(2017) Jia Cao et al.   Nature Communications

Angiocrine signaling in the hepatic sinusoids in health and disease

(2016) Enis Kostallari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sinusoidal communication in liver fibrosis and regeneration

(2016) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

(2015) Douglas A. Simonetto et al.   HEPATOLOGY

p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways

(2015) Meghan Breaux et al.   MOLECULAR AND CELLULAR BIOLOGY

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

(2015) Pratiksha I Thakore et al.   NATURE METHODS

BRD4 is a novel therapeutic target for liver fibrosis

(2015) Ning Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Vascular pathobiology in chronic liver disease and cirrhosis – Current status and future directions

(2014) Yasuko Iwakiri et al.   JOURNAL OF HEPATOLOGY

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis

(2014) Mark A. Barnes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes

(2014) Dev Bhatt et al.   Frontiers in Immunology

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity

(2013) B. Zhang et al.   GENOME RESEARCH

I B  Is a Transcriptional Key Regulator of CCL2/MCP-1

(2013) D. G. Hildebrand et al.   JOURNAL OF IMMUNOLOGY

Functional Role of Monocytes and Macrophages for the Inflammatory Response in Acute Liver Injury

(2012) Henning W. Zimmermann et al.   Frontiers in Physiology

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation

(2011) Massimo Ghizzoni et al.   DRUG DISCOVERY TODAY

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines

(2008) Arnhild Schrage et al.   HEPATOLOGY