Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance

The role of hepatokines in NAFLD

(2023) Norbert Stefan et al.   Cell Metabolism

Fat-distribution Patterns and Future Type-2 Diabetes

(2022) Hajime Yamazaki et al.   DIABETES

Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

(2022) Carlos Kiyoshi Katashima et al.   Science Advances

Oxygen Consumption and Basal Metabolic Rate as Markers of Susceptibility to Malignant Hyperthermia and Heat Stroke

(2022) Matteo Serano et al.   Cells

Muscle follistatin gene delivery increases muscle protein synthesis independent of periodical physical inactivity and fasting

(2021) Tuuli A. Nissinen et al.   FASEB JOURNAL

Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?

(2021) Naresh C. Bal et al.   Frontiers in Physiology

FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance

(2021) Oliver Stöhr et al.   Cell Reports

Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia

(2021) Zhipeng Sun et al.   CIRCULATION

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

(2021) Chuanyan Wu et al.   Nature Communications

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

(2020) Jonathan R. Davey et al.   FASEB JOURNAL

Leptin mediates postprandial increases in body temperature through hypothalamus–adrenal medulla–adipose tissue crosstalk

(2020) Rachel J. Perry et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of insulin resistance related to white, beige, and brown adipocytes

(2020) Michael P. Czech   Molecular Metabolism

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity

(2020) Ruhang Tang et al.   Science Advances

Calsequestrin, a key protein in striated muscle health and disease

(2020) Daniela Rossi et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes

(2020) Sebastian Maciak et al.   BMJ Open Diabetes Research & Care

Mechanisms involved in follistatin‐induced hypertrophy and increased insulin action in skeletal muscle

(2019) Xiuqing Han et al.   Journal of Cachexia Sarcopenia and Muscle

Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

(2019) Zhifen Chen et al.   CIRCULATION RESEARCH

Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity

(2019) Kong Y. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivating hepatic follistatin alleviates hyperglycemia

(2018) Rongya Tao et al.   NATURE MEDICINE

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

(2018) Rajan Singh et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues

(2017) Rajan Singh et al.   ENDOCRINOLOGY

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic risk factors in mice divergently selected for BMR fed high fat and high carb diets

(2017) Julita Sadowska et al.   PLoS One

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

(2016) Cassie M. Tran et al.   DIABETES

Control of energy expenditure in humans

(2016) K R Westerterp   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation

(2016) Xing Zeng et al.   GENES & DEVELOPMENT

Circulating Follistatin Is Liver-Derived and Regulated by the Glucagon-to-Insulin Ratio

(2016) Jakob S. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes

(2016) Jakob Schiøler Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

(2016) Brian T. O’Neill et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating follistatin in relation to energy metabolism

(2016) Jakob Schiøler Hansen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insulin Resistance and a Long, Strange Trip

(2016) Clay F. Semenkovich   NEW ENGLAND JOURNAL OF MEDICINE

Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle

(2016) Meghna Pant et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

(2016) Naoto Kubota et al.   Nature Communications

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

(2016) Maitea Guridi et al.   Skeletal Muscle

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

(2015) Lisa M. DiPilato et al.   MOLECULAR AND CELLULAR BIOLOGY

Sarcolipin is a novel regulator of muscle metabolism and obesity

(2015) Santosh Kumar Maurya et al.   PHARMACOLOGICAL RESEARCH

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

Integration of body temperature into the analysis of energy expenditure in the mouse

(2015) Gustavo Abreu-Vieira et al.   Molecular Metabolism

Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation

(2014) Nancy J. Hançer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

Follistatin promotes adipocyte differentiation, browning, and energy metabolism

(2014) Melissa Braga et al.   JOURNAL OF LIPID RESEARCH

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

(2014) H. Tang et al.   Science Signaling

Plasma follistatin is elevated in patients with type 2 diabetes: relationship to hyperglycemia, hyperinsulinemia, and systemic low-grade inflammation

(2013) J. Hansen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Insulin Resistance in the Defense against Obesity

(2012) Alan R. Saltiel   Cell Metabolism

IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action

(2012) Marianna Sadagurski et al.   Cell Metabolism

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Resting Energy Expenditure and Energetic Cost of Feeding Are Augmented after Roux-en-Y Gastric Bypass in Obese Mice

(2012) Eirini Nestoridi et al.   ENDOCRINOLOGY

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Core temperature: a forgotten variable in energy expenditure and obesity?

(2012) L. Landsberg   Obesity Reviews

Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting

(2012) John J McCarthy et al.   Skeletal Muscle

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Follistatin and Follistatin Like-3 Differentially Regulate Adiposity and Glucose Homeostasis

(2011) Melissa L. Brown et al.   Obesity

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine

(2010) Jakob Hansen et al.   ENDOCRINOLOGY

Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

(2010) Y. C. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Emerging roles for the TGFβ family in pancreatic β-cell homeostasis

(2010) Melissa L. Brown et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

Human IL6 enhances leptin action in mice

(2009) M. Sadagurski et al.   DIABETOLOGIA

Is obesity associated with lower body temperatures? Core temperature: a forgotten variable in energy balance

(2009) Lewis Landsberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

(2009) S. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

(2008) Adel Amirouche et al.   ENDOCRINOLOGY

Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats

(2008) Ramin Alemzadeh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes

(2008) Natalie R. Lenard et al.   Obesity