Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

The Post-GWAS Era: From Association to Function

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CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Humanity in a Dish: Population Genetics with iPSCs

(2018) Curtis R. Warren et al.   TRENDS IN CELL BIOLOGY

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma

(2017) Lucille Morzyglod et al.   HEPATOLOGY

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

(2017) Wei Zhao et al.   NATURE GENETICS

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

(2017) Gijs H. Goossens   Obesity Facts

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

(2016) Soren K. Thomsen et al.   DIABETES

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

Type 2 diabetes: genetic data sharing to advance complex disease research

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Lack of AKT in adipocytes causes severe lipodystrophy

(2016) Abigail L. Shearin et al.   Molecular Metabolism

Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

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Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications

(2015) Yinan Hua et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

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A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

(2015) Nivedita Patni et al.   Nature Reviews Endocrinology

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

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Tissue-specific insulin signaling in the regulation of metabolism and aging

(2014) Jingjing Zhang et al.   IUBMB LIFE

Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance

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Mechanisms for Insulin Resistance: Common Threads and Missing Links

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Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Prolidase Directly Binds and Activates Epidermal Growth Factor Receptor and Stimulates Downstream Signaling

(2012) Lu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential function of Akt1 and Akt2 in human adipocytes

(2012) Pamela Fischer-Posovszky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

The association of serum prolidase activity with the presence and severity of coronary artery disease

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Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry