Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity

2,4 Dinitrophenol as Medicine

(2019) John Geisler   Cells

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

(2019) Naja Z. Jespersen et al.   Molecular Metabolism

Safety and Effectiveness of Longer‐Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort

(2019) Kristina H. Lewis et al.   Obesity

Compensation for cold-induced thermogenesis during weight loss maintenance and regain

(2019) David M. Presby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adrenoceptors in white, brown, and brite adipocytes

(2019) Bronwyn A. Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic Determinants of Weight Gain in Humans

(2019) Paolo Piaggi   Obesity

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

(2019) Giorgia Schena et al.   Cells

Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic phenotypes

(2019) Tim Hollstein et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with 18F-Fluorodeoxyglucose in Humans

(2019) Tyler J. Fraum et al.   Cell Metabolism

Quantification of the capacity for cold-induced thermogenesis in young men with and without obesity

(2019) Robert J Brychta et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown and Beige Adipose Tissue and Aging

(2019) Elena Zoico et al.   Frontiers in Endocrinology

Is Activation of Human Brown Adipose Tissue a Viable Target for Weight Management?

(2018) Kara L Marlatt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides

(2018) Graeme Weir et al.   Cell Metabolism

Recent advances in the detection of brown adipose tissue in adult humans: a review

(2018) Frank J. Ong et al.   CLINICAL SCIENCE

Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist

(2018) Alison S. Baskin et al.   DIABETES

Hypothalamic AMPK and energy balance

(2018) Miguel López   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The role and mechanism of action of menthol in topical analgesic products

(2018) J. V. Pergolizzi et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Obesity

(2018) Kishore M. Gadde et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Acute metabolic and cardiovascular effects of mirabegron in healthy individuals

(2018) Rebecca K. C. Loh et al.   DIABETES OBESITY & METABOLISM

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Compensation in response to energy deficits induced by exercise or diet

(2018) É. Doucet et al.   Obesity Reviews

Skeletal Muscle-Specific Overexpression of PGC-1α Induces Fiber-Type Conversion through Enhanced Mitochondrial Respiration and Fatty Acid Oxidation in Mice and Pigs

(2017) Lin Zhang et al.   International Journal of Biological Sciences

Increased Physical Activity Associated with Less Weight Regain Six Years After “The Biggest Loser” Competition

(2017) Jennifer C. Kerns et al.   Obesity

Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?

(2017) Miguel López et al.   PHARMACOLOGY & THERAPEUTICS

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

(2017) Jialu Wang et al.   Nature Communications

Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity

(2017) Changyu Jiang et al.   Oncotarget

Phoenix from the Ashes: Fire, Torpor, and the Evolution of Mammalian Endothermy

(2017) Fritz Geiser et al.   Frontiers in Physiology

No insulating effect of obesity

(2016) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Characterizing active and inactive brown adipose tissue in adult humans using PET-CT and MR imaging

(2016) Aliya Gifford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Creatine transporter deficiency leads to increased whole body and cellular metabolism

(2016) Marla K. Perna et al.   AMINO ACIDS

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

(2016) Lydia Lynch et al.   Cell Metabolism

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

(2016) Kong Y. Chen et al.   Cell Metabolism

Cold-induced thermogenesis in humans

(2016) R J Brychta et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus

(2016) Mueez u Din et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Accurate MR thermometry by hyperpolarized 129 Xe

(2016) Le Zhang et al.   MAGNETIC RESONANCE IN MEDICINE

Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats

(2016) REBECCA J. WELLY et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Persistent metabolic adaptation 6 years after “The Biggest Loser” competition

(2016) Erin Fothergill et al.   Obesity

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity

(2015) Andrew L. Carey et al.   DIABETOLOGIA

Case Study: Weight loss in a patient with type 2 diabetes: Challenges of diabetes management

(2015) Katayoun Lotfi et al.   Obesity

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Integration of body temperature into the analysis of energy expenditure in the mouse

(2015) Gustavo Abreu-Vieira et al.   Molecular Metabolism

Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice

(2014) Rebecca E. K. MacPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cold-activated brown adipose tissue in human adults: methodological issues

(2014) Anouk A. J. J. van der Lans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

Brown Fat in Humans: Consensus Points and Experimental Guidelines

(2014) Aaron M. Cypess et al.   Cell Metabolism

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

Nicotine Improves Obesity and Hepatic Steatosis and ER Stress in Diet-Induced Obese Male Rats

(2014) Patricia Seoane-Collazo et al.   ENDOCRINOLOGY

Role of Gsα in Central Regulation of Energy and Glucose Metabolism

(2014) L. Weinstein   HORMONE AND METABOLIC RESEARCH

Healthy Weight Loss

(2014) Eve Guth   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cardiovascular effects of phentermine and topiramate

(2014) Jens Jordan et al.   JOURNAL OF HYPERTENSION

Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men

(2014) Denis P. Blondin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes

(2014) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin

(2014) Nicolas D. Knuth et al.   Obesity

Effect of Intermittent Cold Exposure on Brown Fat Activation, Obesity, and Energy Homeostasis in Mice

(2014) Yann Ravussin et al.   PLoS One

The collaboration of Antoine and Marie-Anne Lavoisier and the first measurements of human oxygen consumption

(2013) John B. West   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

New Obesity Agents: Lorcaserin and Phentermine/Topiramate

(2013) Joshua W Fleming et al.   ANNALS OF PHARMACOTHERAPY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

(2013) O. Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

Resistance to Exercise-Induced Weight Loss

(2013) EDWARD L. MELANSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production

(2013) Marco Rossato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

(2013) Jonathan Mowers et al.   eLife

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase

(2012) P. B. Martinez de Morentin et al.   DIABETES

Ephedrine activates brown adipose tissue in lean but not obese humans

(2012) A. L. Carey et al.   DIABETOLOGIA

Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation

(2012) J. E. Blundell et al.   Disease Models & Mechanisms

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)

(2012) Ajit S. Divakaruni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Slowing with Massive Weight Loss despite Preservation of Fat-Free Mass

(2012) Darcy L. Johannsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

β1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice

(2012) Cintia B Ueta et al.   JOURNAL OF ENDOCRINOLOGY

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

Evolving concepts on adjusting human resting energy expenditure measurements for body size

(2012) S. B. Heymsfield et al.   Obesity Reviews

Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis

(2012) D. M. Thomas et al.   Obesity Reviews

Cold but not sympathomimetics activates human brown adipose tissue in vivo

(2012) A. M. Cypess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

(2012) Shuangtao Ma et al.   Journal of Molecular Cell Biology

The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans

(2011) M.-J. Ludy et al.   CHEMICAL SENSES

Metabolic sequelae of β-blocker therapy: weighing in on the obesity epidemic?

(2011) P Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Quantification of the effect of energy imbalance on bodyweight

(2011) Kevin D Hall et al.   LANCET

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Long-Term Persistence of Hormonal Adaptations to Weight Loss

(2011) Priya Sumithran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Challenges in β3-adrenoceptor agonist drug development

(2011) Jonathan R. S. Arch   Therapeutic Advances in Endocrinology and Metabolism

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

Nicotine Addiction

(2010) Neal L. Benowitz   NEW ENGLAND JOURNAL OF MEDICINE

Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial

(2010) TszYing Lee et al.   Nutrition & Metabolism

Caffeine Prevents Transcription Inhibition and P-TEFb/7SK Dissociation Following UV-Induced DNA Damage

(2010) Giuliana Napolitano et al.   PLoS One

Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone

(2009) Christopher D. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Some Unanswered Questions About Temperature Management

(2009) Jonathan V. Roth   ANESTHESIA AND ANALGESIA

Central sympathetic overactivity: Maladies and mechanisms

(2009) James P. Fisher et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Effect of capsinoids on energy metabolism in human subjects

(2009) Jose E. Galgani et al.   BRITISH JOURNAL OF NUTRITION

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens

(2009) Vincent A. Robert et al.   JOURNAL OF INFECTIOUS DISEASES

Effects of Habitat Conversion on Temporal Activity Patterns of Phyllostomid Bats in Lowland Amazonian Rain Forest

(2009) Steven J. Presley et al.   JOURNAL OF MAMMALOGY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY