Fucoidan, a brown seaweed polysaccharide in nanodrug delivery

Antioxidative Stress and Anti-Inflammatory Activity of Fucoidan Nanoparticles against Nephropathy of Streptozotocin-Induced Diabetes in Rats

(2022) Giftania Wardani et al.   Evidence-based Complementary and Alternative Medicine

Novel ROS-responsive marine biomaterial fucoidan nanocarriers with AIE effect and chemodynamic therapy

(2022) Chunjing Guo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hypoxia responsive fucoidan-based micelles for oxidative stress-augmented chemotherapy

(2022) Li Li et al.   EUROPEAN POLYMER JOURNAL

Fucoidan-based nanoparticles: Preparations and applications

(2022) Jayachandran Venkatesan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Comparison of in vitro and in vivo antioxidant activities of commercial fucoidans from Macrocystis pyrifera, Undaria pinnatifida, and Fucus vesiculosus

(2022) Maylla Maria Correia Leite Silva et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeting Mitochondrial Biogenesis with Polyphenol Compounds

(2021) Leila Chodari et al.   Oxidative Medicine and Cellular Longevity

Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment

(2021) Rong Guo et al.   Acta Pharmaceutica Sinica B

Fucoidan Extracted From Sporophyll of Undaria pinnatifida Grown in Weihai, China – Chemical Composition and Comparison of Antioxidant Activity of Different Molecular Weight Fractions

(2021) Jing Yu et al.   Frontiers in Nutrition

Structural characterization of a P-selectin and EGFR dual-targeting fucoidan from Sargassum fusiforme

(2021) Xue Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

One-Minute Synthesis of Size-Controlled Fucoidan-Gold Nanosystems: Antitumoral Activity and Dark Field Imaging

(2020) Ricardo J. B. Pinto et al.   Materials

The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

(2020) Yuan Lin et al.   Cancer Cell International

In vitro/vivo evaluation of novel mitochondrial targeting charge-reversal polysaccharide-based antitumor nanoparticle

(2020) Lei Fang et al.   CARBOHYDRATE POLYMERS

Radioprotective effect of self-assembled low molecular weight Fucoidan–Chitosan nanoparticles

(2020) Szu-Yuan Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fucoidans: Downstream Processes and Recent Applications

(2020) Ahmed Zayed et al.   Marine Drugs

Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes

(2020) Elham Ahmadian et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems

(2020) Catarina Oliveira et al.   CARBOHYDRATE POLYMERS

Zein/fucoidan-based composite nanoparticles for the encapsulation of pterostilbene: Preparation, characterization, physicochemical stability, and formation mechanism

(2020) Qianyuan Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate

(2020) Ana J. Coutinho et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Biosynthesis of AgNPs onto the urea-based periodic mesoporous organosilica (AgxNPs/Ur-PMO) for antibacterial and cell viability assay

(2020) Amir Hasanzadeh et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Synthesis and characterization of Gd-DTPA/fucoidan/peptide complex nanoparticle and in vitro magnetic resonance imaging of inflamed endothelial cells

(2020) Tsai-Mu Cheng et al.   Materials Science & Engineering C-Materials for Biological Applications

Nanotheranostics With the Combination of Improved Targeting, Therapeutic Effects, and Molecular Imaging

(2020) Shin-Lei Peng et al.   Frontiers in Bioengineering and Biotechnology

Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy

(2020) Mina Jafari et al.   CARBOHYDRATE POLYMERS

Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury

(2020) Gaofeng Shu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery

(2019) Ana Barbosa et al.   MOLECULES

Fucoidan production: Approval key challenges and opportunities

(2019) Ahmed Zayed et al.   CARBOHYDRATE POLYMERS

Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand

(2019) Hui Si Audrey Koh et al.   CARBOHYDRATE POLYMERS

Carrageenan: A Wonder Polymer from Marine Algae for Potential Drug Delivery Applications

(2019) Dilshad Qureshia et al.   CURRENT PHARMACEUTICAL DESIGN

Subcritical water extraction as an efficient technique to isolate biologically-active fucoidans from Nizamuddinia zanardinii

(2019) Mehdi Alboofetileh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Natural biodegradable polymers based nano-formulations for drug delivery: A review

(2019) Archana George et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine

(2019) Alaaldin M. Alkilany et al.   ADVANCED DRUG DELIVERY REVIEWS

Soluble eggshell membrane protein-loaded chitosan/fucoidan nanoparticles for treatment of defective intestinal epithelial cells

(2019) Meng-Chen Lee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles

(2019) Dae Gun Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs

(2019) Leah Guthrie et al.   eLife

Therapeutic Effects of Fucoidan: A Review on Recent Studies

(2019) Sibusiso Luthuli et al.   Marine Drugs

Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms

(2019) Aleksandra Citkowska et al.   Marine Drugs

Enhancing the Extraction of Polysaccharides and Antioxidants from Macroalgae Using Sequential Hydrothermal-Assisted Extraction Followed by Ultrasound and Thermal Technologies

(2019) Marco Garcia-Vaquero et al.   Marine Drugs

Low-molecular-weight fucoidan: Chemical modification, synthesis of its oligomeric fragments and mimetics

(2019) Viktoria Evgenievna Suprunchuk   CARBOHYDRATE RESEARCH

“Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring”

(2019) Samar M. Etman et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A fucoidan-quaternary chitosan nanoparticle adjuvant for anthrax vaccine as an alternative to CpG oligodeoxynucleotides

(2019) Chuan-Chang Chuang et al.   CARBOHYDRATE POLYMERS

Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer

(2019) Samar M. Etman et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan-based nanostructures: A focus on its combination with chitosan and the surface functionalization of metallic nanoparticles for drug delivery

(2019) Phuong H.L. Tran et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

(2019) Bilal et al.   Marine Drugs

Fucoidans: The importance of processing on their anti-tumoral properties

(2019) M.D. Torres et al.   Algal Research-Biomass Biofuels and Bioproducts

The promising future of nano-antioxidant therapy against environmental pollutants induced-toxicities

(2018) Aziz Eftekhari et al.   BIOMEDICINE & PHARMACOTHERAPY

Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs

(2018) Chien-Ho Chen et al.   CARBOHYDRATE POLYMERS

The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity

(2018) Huaide Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats

(2018) Zhiqiang Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hydrophobic ionic liquid modified thermo-responsive molecularly imprinted monolith for the selective recognition and separation of tanshinones

(2018) Weiyang Tang et al.   JOURNAL OF SEPARATION SCIENCE

An immobilized perylene diimide derivative for fucoidan purification from a crude brown algae extract

(2018) Ahmed Zayed et al.   PROCESS BIOCHEMISTRY

Fucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer

(2018) Bian Jang et al.   Oncotarget

Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells

(2018) Catarina Oliveira et al.   Nanomedicine

A novel rutin-fucoidan complex based phytotherapy for cervical cancer through achieving enhanced bioavailability and cancer cell apoptosis

(2018) Murugesan Sathiya Deepika et al.   BIOMEDICINE & PHARMACOTHERAPY

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

(2018) Pei Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin

(2018) Li-Chu Tsai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients

(2017) Hidenori Takahashi et al.   INTEGRATIVE CANCER THERAPIES

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

(2017) Hsiang-Lin Tsai et al.   Marine Drugs

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

(2017) Jun-Hyeong Park et al.   Marine Drugs

A review about the development of fucoidan in antitumor activity: Progress and challenges

(2016) Lei Wu et al.   CARBOHYDRATE POLYMERS

Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery

(2016) Yi-Cheng Huang et al.   CARBOHYDRATE POLYMERS

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Seaweeds: A resource for marine bionanotechnology

(2016) Sri Ramkumar Vijayan et al.   ENZYME AND MICROBIAL TECHNOLOGY

The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer

(2016) Shreya Tocaciu et al.   INTEGRATIVE CANCER THERAPIES

Marine polysaccharide-based nanomaterials as a novel source of nanobiotechnological applications

(2016) Panchanathan Manivasagan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging

(2016) Panchanathan Manivasagan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cytotoxic effect of fucoidan extracted from Sargassum cinereum on colon cancer cell line HCT-15

(2016) Sivasankara Narayani Somasundaram et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Marine Origin Polysaccharides in Drug Delivery Systems

(2016) Matias Cardoso et al.   Marine Drugs

Fucoidans in Nanomedicine

(2016) Lucas Chollet et al.   Marine Drugs

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

(2016) Ludmylla Cunha et al.   Marine Drugs

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

(2016) Jayachandran Venkatesan et al.   Polymers

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

(2015) Pai-An Hwang et al.   CYTOTECHNOLOGY

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

(2015) Akihiro Kasai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer

(2015) D. Pádua et al.   Phytochemistry Letters

Antioxidant activities of fucoidan degraded by gamma irradiation and acidic hydrolysis

(2015) Sangyong Lim et al.   RADIATION PHYSICS AND CHEMISTRY

Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice

(2015) Tao Zuo et al.   Food & Function

Are multifunctional marine polysaccharides a myth or reality?

(2015) Svetlana Ermakova et al.   Frontiers in Chemistry

Fucoidans: Pro- or antiangiogenic agents?

(2014) N. E. Ustyuzhanina et al.   GLYCOBIOLOGY

Delivery of Berberine Using Chitosan/Fucoidan-Taurine Conjugate Nanoparticles for Treatment of Defective Intestinal Epithelial Tight Junction Barrier

(2014) Shao-Jung Wu et al.   Marine Drugs

Fucoidan as a Marine Anticancer Agent in Preclinical Development

(2014) Jong-Young Kwak   Marine Drugs

Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment

(2013) Kun Woo Lee et al.   CARBOHYDRATE POLYMERS

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

The Magnitude of Global Marine Species Diversity

(2012) Ward Appeltans et al.   CURRENT BIOLOGY

Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways

(2012) Hyunkyoung Lee et al.   PLoS One

Novel procedures for the extraction of fucoidan from brown algae

(2012) Thomas Hahn et al.   PROCESS BIOCHEMISTRY

Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection

(2012) Naoki Mori   WORLD JOURNAL OF GASTROENTEROLOGY

Fucoidans as a natural bioactive ingredient for functional foods

(2012) Thanh-Sang Vo et al.   Journal of Functional Foods

Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles

(2011) Yi-Cheng Huang et al.   Acta Biomaterialia

Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review

(2011) W.A.J.P. Wijesinghe et al.   CARBOHYDRATE POLYMERS

Acid-promoted synthesis of per-O-sulfated fucooligosaccharides related to fucoidan fragments

(2011) Vadim B. Krylov et al.   CARBOHYDRATE RESEARCH

Cytotoxicity and cellular uptake of newly synthesized fucoidan-coated nanoparticles

(2011) M.C.B. Lira et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Chemical Modification of Botryosphaeran: Structural Characterization and Anticoagulant Activity of a Water-Soluble Sulfonated (1→3)(1→6)-β-D-Glucan

(2011) Jamile Brandi   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

(2011) Guangling Jiao et al.   Marine Drugs

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

(2011) MASAHIDE IKEGUCHI et al.   Oncology Letters

Development of a Fucoidan-Specific Antibody and Measurement of Fucoidan in Serum and Urine by Sandwich ELISA

(2010) Yoshiharu TOKITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

(2010) Myoung Lae Cho et al.   MOLECULES

Structural characteristics and in vitro macrophage activation of acetyl fucoidan from Cladosiphon okamuranus

(2009) Takeshi Teruya et al.   GLYCOCONJUGATE JOURNAL

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Fucoidans and fucoidanases—focus on techniques for molecular structure elucidation and modification of marine polysaccharides

(2008) Andrea Désirée Holtkamp et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES