Targeting Mitochondrial Biogenesis with Polyphenol Compounds

Increased mitochondrial content and function by resveratrol and select flavonoids protects against benzo[a]pyrene-induced bioenergetic dysfunction and ROS generation in a cell model of neoplastic transformation

(2020) Kosar Omidian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural products, PGC-1α, and Duchenne muscular dystrophy

(2020) Ipek Suntar et al.   Acta Pharmaceutica Sinica B

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glycyrrhizic acid exerts protective effects against hypoxia/reoxygenation‑induced human coronary artery endothelial cell damage by regulating mitochondria

(2020) Quan Tang et al.   Experimental and Therapeutic Medicine

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

(2020) Zhibin Liang et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial presequence import: Multiple regulatory knobs fine-tune mitochondrial biogenesis and homeostasis

(2019) Cyril Moulin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis

(2019) Theodomir Dusabimana et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury

(2019) Ehtesham Arif et al.   KIDNEY INTERNATIONAL

The antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation and oxidative stress: A systematic review

(2019) Gomes Jaqueline Vieira Piovezana et al.   NUTRITION

Limited predictive value of TFAM in mitochondrial biogenesis

(2019) Natalya Kozhukhar et al.   MITOCHONDRION

Modulatory effects of curcumin on the atherogenic activities of inflammatory monocytes: Evidence from in vitro and animal models of human atherosclerosis

(2019) Saeed Mohammadian Haftcheshmeh et al.   BIOFACTORS

Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats

(2018) Linan Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

The critical role of epigallocatechin gallate in regulating mitochondrial metabolism

(2018) Weimei Shi et al.   Future Medicinal Chemistry

Structural Modification of (−)-Epigallocatechin Gallate (EGCG) Shows Significant Enhancement in Mitochondrial Biogenesis

(2018) Taewoong Ha et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High-Fat-Diet-Induced Obese Mice

(2018) Tanila Wood dos Santos et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxytyrosol Ameliorates Endothelial Function under Inflammatory Conditions by Preventing Mitochondrial Dysfunction

(2018) Nadia Calabriso et al.   Oxidative Medicine and Cellular Longevity

Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention

(2018) Devesh Tewari et al.   PHARMACOLOGICAL RESEARCH

Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes

(2018) Isao Masuda et al.   Scientific Reports

Cyanidin-3-glucoside enhances mitochondrial function and biogenesis in a human hepatocyte cell line

(2018) Rashad Mogalli et al.   CYTOTECHNOLOGY

Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis

(2018) Tanila Wood dos Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Isorhamnetin on Adipocyte Mitochondrial Biogenesis and AMPK Activation

(2018) Mak-Soon Lee et al.   MOLECULES

Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance

(2018) Guangning Kou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Glycyrrhizic Acid Ameliorates Mitochondrial Function and Biogenesis Against Aluminum Toxicity in PC12 Cells

(2018) Marzieh Rashedinia et al.   NEUROTOXICITY RESEARCH

Biogenesis of a Mitochondrial Outer Membrane Protein inTrypanosoma brucei

(2017) Julia Bruggisser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial biogenesis in neurodegeneration

(2017) P. Andy Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Increasing cAMP levels of preadipocytes by cyanidin-3-glucoside treatment induces the formation of beige phenotypes in 3T3-L1 adipocytes

(2017) Toshiya Matsukawa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mulberry anthocyanins, cyanidin 3-glucoside and cyanidin 3-rutinoside, increase the quantity of mitochondria during brown adipogenesis

(2017) Yilin You et al.   Journal of Functional Foods

Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice

(2017) Mak-Soon Lee et al.   Food & Nutrition Research

Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

(2017) Robert B. Cameron et al.   Scientific Reports

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Translational regulation of mitochondrial biogenesis

(2016) Y. Zhang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Quercetin and the mitochondria: A mechanistic view

(2016) Marcos Roberto de Oliveira et al.   BIOTECHNOLOGY ADVANCES

The TIM23 mitochondrial protein import complex: function and dysfunction

(2016) Keren Demishtein-Zohary et al.   CELL AND TISSUE RESEARCH

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

Resveratrol attenuates oxidative stress in mitochondrial Complex I deficiency: Involvement of SIRT3

(2016) Lise Mathieu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases

(2016) Robert B. Cameron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

(2016) Hirotaka Yamamoto et al.   Oxidative Medicine and Cellular Longevity

Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment

(2016) Peng Zou et al.   Oxidative Medicine and Cellular Longevity

The Effects of Ascorbate, N-Acetylcysteine, and Resveratrol on Fibroblasts from Patients with Mitochondrial Disorders

(2016) Liza Douiev et al.   Journal of Clinical Medicine

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

(2016) Xiang Li et al.   PLoS One

Natural Compounds Modulating Mitochondrial Functions

(2015) Lara Gibellini et al.   Evidence-based Complementary and Alternative Medicine

Mitochondrial biogenesis and dynamics in the developing and diseased heart

(2015) Gerald W. Dorn et al.   GENES & DEVELOPMENT

Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes

(2015) Hye-Lin Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondrial dynamics: Orchestrating the journey to advanced age

(2015) Agnieszka K. Biala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism

(2015) Kazuya Toda et al.   Journal of Natural Medicines

Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels

(2015) Ronald D. Ray Hamidie et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways

(2015) M. Nichols et al.   NEUROSCIENCE

Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway

(2015) Deep Raj Sharma et al.   NEUROTOXICOLOGY

Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1

(2015) Chu-Sook Kim et al.   Nutrition & Metabolism

Digitoflavone provokes mitochondrial biogenesis in PC12 cells: A protective approach to oxidative stress

(2015) Asal Yans et al.   PHARMACEUTICAL BIOLOGY

Mulberry and mulberry wine extract increase the number of mitochondria during brown adipogenesis

(2015) Yilin You et al.   Food & Function

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

(2015) Naïg Gueguen et al.   PLoS One

Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state

(2014) Anna Signorile et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

The combination of oral quercetin supplementation and exercise prevents brain mitochondrial biogenesis

(2014) Rafael Antonio Casuso et al.   Genes and Nutrition

In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity

(2014) T. M. Henagan et al.   Genes and Nutrition

Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin

(2014) Dawn Chin et al.   Genes and Nutrition

Rutin, a Flavonoid and Principal Component of Saussurea Involucrata, Attenuates Physical Fatigue in a Forced Swimming Mouse Model

(2014) Kang-Yi Su et al.   International Journal of Medical Sciences

The Protective Effect of Glycyrrhizic Acid on Renal Tubular Epithelial Cell Injury Induced by High Glucose

(2014) Shaozhang Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary antiaging phytochemicals and mechanisms associated with prolonged survival

(2014) Hongwei Si et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle

(2014) Rie Tsutsumi et al.   Nutrition & Metabolism

Anthocyanins Inhibit Lipogenesis During Adipocyte Differentiation of 3T3-L1 Preadipocytes

(2014) Bonggi Lee et al.   PLANT FOODS FOR HUMAN NUTRITION

Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis

(2014) Masanori Hiramitsu et al.   Scientific Reports

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome

(2013) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Beneficial effects of resveratrol on respiratory chain defects in patients' fibroblasts involve estrogen receptor and estrogen-related receptor alpha signaling

(2013) A. Lopes Costa et al.   HUMAN MOLECULAR GENETICS

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells

(2013) Valérie Desquiret-Dumas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8

(2013) Gunter P. Eckert et al.   NEUROCHEMISTRY INTERNATIONAL

Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells

(2013) Nabin Rayamajhi et al.   Oxidative Medicine and Cellular Longevity

Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats

(2013) Hasibur Rehman et al.   PLoS One

Hepatoprotective effect of silyamarin in individuals chronically exposed to hydrogen sulfide; modulating influence of TNF-alpha cytokine genetic polymorphism

(2013) Ali Mandegary et al.   DARU-Journal of Pharmaceutical Sciences

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Scutellaria baicalensisExtracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction

(2012) A-Rang Im et al.   Evidence-based Complementary and Alternative Medicine

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A perspective on the determination of mitochondrial biogenesis

(2011) Benjamin F. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

(2011) Pam R. Taub et al.   CTS-Clinical and Translational Science

Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol

(2011) Zhihui Feng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Liaisons of p53

(2010) Lorenzo Galluzzi et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

(2010) Michel Rigoulet et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes

(2010) Agnieszka Biala et al.   BLOOD PRESSURE

Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues

(2010) Marcella Fulco et al.   CELL CYCLE

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Mitochondrial Biogenesis and Peroxisome Proliferator-Activated Receptor-  Coactivator-1  (PGC-1 ) Deacetylation by Physical Activity: Intact Adipocytokine Signaling Is Required

(2010) L. Li et al.   DIABETES

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

(2010) Lu Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis

(2010) DAVID C. NIEMAN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

(2009) J. Mark Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

(2009) Jiejie Hao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

(2008) Ligia C. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoflavones Promote Mitochondrial Biogenesis

(2008) K. A. Rasbach et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS