Fucoidan as a Marine Anticancer Agent in Preclinical Development

Ovarian Tumor-Induced T Cell Suppression Is Alleviated by Vascular Leukocyte Depletion

(2014) S. Peter et al.   Translational Oncology

Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis

(2013) Cong Zhu et al.   Evidence-based Complementary and Alternative Medicine

Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

(2013) Kalimuthu Senthilkumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Major Vault Protein Regulates Class A Scavenger Receptor-mediated Tumor Necrosis Factor-α Synthesis and Apoptosis in Macrophages

(2013) Jingjing Ben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Scavenger Receptor A Promotes Tumor Progression in Murine Models of Ovarian and Pancreatic Cancer

(2013) C. Neyen et al.   JOURNAL OF IMMUNOLOGY

Cytokine patterns in patients with cancer: a systematic review

(2013) Bodo E Lippitz   LANCET ONCOLOGY

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

(2013) Lili Yang et al.   Marine Drugs

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei

(2013) Pham Thinh et al.   Marine Drugs

Marine-Derived Angiogenesis Inhibitors for Cancer Therapy

(2013) Ying-Qing Wang et al.   Marine Drugs

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

(2013) Hyun Park et al.   Marine Drugs

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

(2013) Hye-Jin Boo et al.   Marine Drugs

Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling

(2013) Meilan Xue et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Low Molecular Weight Fucoidan against Renal Ischemia–Reperfusion Injury via Inhibition of the MAPK Signaling Pathway

(2013) Jihui Chen et al.   PLoS One

Class A Scavenger Receptor Deficiency Exacerbates Lung Tumorigenesis by Cultivating a Procarcinogenic Microenvironment in Humans and Mice

(2012) Jingjing Ben et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective effect of fucoidan against acetaminophen-induced liver injury

(2012) Sang-Won Hong et al.   ARCHIVES OF PHARMACAL RESEARCH

Fucanomics and galactanomics: Current status in drug discovery, mechanisms of action and role of the well-defined structures

(2012) Vitor H. Pomin   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis

(2012) Veeraperumal Suresh et al.   CARBOHYDRATE POLYMERS

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia

(2012) Yan-Qiu Cui et al.   CNS Neuroscience & Therapeutics

In vitro antioxidant properties of crude extracts and compounds from brown algae

(2012) Elena M. Balboa et al.   FOOD CHEMISTRY

Neuroprotective effect of fucoidin on lipopolysaccharide accelerated cerebral ischemic injury through inhibition of cytokine expression and neutrophil infiltration

(2012) Gu Hyun Kang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

(2012) Kazuo Azuma et al.   Marine Drugs

Overcoming Resistance to Antiangiogenic Therapies

(2012) S. Tejpar et al.   ONCOLOGIST

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

(2012) Fang Liu et al.   PHYTOMEDICINE

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

(2011) Sang-Won HONG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia–reperfusion injury in rats via regulating the inflammation response

(2011) Chunmei Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

(2011) Marcel Tutor Ale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants

(2011) S. Kar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Caveolae-dependent Endocytosis Is Required for Class A Macrophage Scavenger Receptor-mediated Apoptosis in Macrophages

(2011) Xu-Dong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential of Fucoidan in Myocardial Ischemia

(2011) Stéphane Manzo-Silberman et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Antiproliferative Activity of Fucoidan Was Associated with the Induction of Apoptosis and Autophagy in AGS Human Gastric Cancer Cells

(2011) Hyun Soo Park et al.   JOURNAL OF FOOD SCIENCE

Therapies from Fucoidan; Multifunctional Marine Polymers

(2011) Janet Helen Fitton   Marine Drugs

Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells

(2011) Hye-Jin Boo et al.   PHYTOTHERAPY RESEARCH

Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways

(2011) Zhongyuan Zhang et al.   PLoS One

The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention

(2010) Joshua D. Lambert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells

(2010) Yaling Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats

(2010) Hanumantha Rao Balaji Raghavendran et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sulfated Polysaccharide Fucoidan Ameliorates Experimental Autoimmune Myocarditis in Rats

(2010) Komei Tanaka et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

CXCR4 and cancer

(2010) Bungo Furusato et al.   PATHOLOGY INTERNATIONAL

Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitization

(2009) Yuhki Yanase et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor- 

(2009) J.-O Jin et al.   BLOOD

Pilot clinical study to evaluate the anticoagulant activity of fucoidan

(2009) Mohammad R Irhimeh et al.   BLOOD COAGULATION & FIBRINOLYSIS

Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-γ production by tumor-associated macrophages

(2009) Yoshihiro Komohara et al.   CANCER SCIENCE

Effect of fucoidan on aspirin-induced stomach ulceration in rats

(2009) Jong-il Choi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fucoidan protects against dopaminergic neuron death in vivo and in vitro

(2009) Dingzhen Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Requirement of L-selectin for γδ T lymphocyte activation and migration during allergic pleurisy: Co-relation with eosinophil accumulation

(2009) Maria Fernanda S. Costa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The effects of fucoidan extracts on CCl4-induced liver injury

(2008) Kum Suk Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets

(2008) Laure Bachelet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds

(2008) Mikhail Kusaykin et al.   Biotechnology Journal

Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A

(2008) M. Narazaki et al.   BLOOD

Structure, biology, evolution, and medical importance of sulfated fucans and galactans

(2008) V. H Pomin et al.   GLYCOBIOLOGY

Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells

(2008) Meixiang Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

(2008) Chen Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

New insights on the role of CXCR4 in cancer metastasis

(2008) A Zlotnik   JOURNAL OF PATHOLOGY

Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells

(2007) Mi-Hyoung Kim et al.   IMMUNOLOGY LETTERS