Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

(2020) Alessandra Metelli et al.   Science Translational Medicine

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression

(2020) Senbiao Chen et al.   Nano Today

Activated Platelets-Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer

(2019) Yujie Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy

(2019) Yu Huang et al.   JOURNAL OF CONTROLLED RELEASE

Platelets as platforms for inhibition of tumor recurrence post-physical therapy by delivery of anti-PD-L1 checkpoint antibody

(2019) Xiao Han et al.   JOURNAL OF CONTROLLED RELEASE

Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy

(2019) Yixuan Tang et al.   ACS Nano

Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles

(2019) Xiaoli Mai et al.   BIOMATERIALS

Self-Delivery Micellar Nanoparticles Prevent Premetastatic Niche Formation by Interfering with the Early Recruitment and Vascular Destruction of Granulocytic Myeloid-Derived Suppressor Cells

(2019) Yang Long et al.   NANO LETTERS

Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin

(2018) Maya Juenet et al.   BIOMATERIALS

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

(2018) Xiaohong Ruby Xu et al.   BLOOD

The Platelet Lifeline to Cancer: Challenges and Opportunities

(2018) Monika Haemmerle et al.   CANCER CELL

Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

(2018) Chih-Sheng Chiang et al.   Nature Nanotechnology

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

(2018) Xudong Zhang et al.   NANO LETTERS

Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus

(2018) Bo Li et al.   BIOMATERIALS

Platelet for drug delivery

(2018) Yifei Lu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Effect of inhibitors of endocytosis and NF-kB signal pathway on folate-conjugated nanoparticle endocytosis by rat Kupffer cells

(2017) Hongbo Tang et al.   International Journal of Nanomedicine

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

(2016) Quanyin Hu et al.   ADVANCED MATERIALS

Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

(2016) Chihiro Mitsui et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape

(2016) Malte Mohme et al.   Nature Reviews Clinical Oncology

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Development of Polymer Microcapsules Functionalized with Fucoidan to Target P-Selectin Overexpressed in Cardiovascular Diseases

(2016) Bo Li et al.   Advanced Healthcare Materials

Anticancer Platelet-Mimicking Nanovehicles

(2015) Quanyin Hu et al.   ADVANCED MATERIALS

Platelets at the interface of thrombosis, inflammation, and cancer

(2015) A. T. Franco et al.   BLOOD

The Role of TLR4 in Chemotherapy-Driven Metastasis

(2015) S. Ran   CANCER RESEARCH

Therapies from Fucoidan: An Update

(2015) Janet Fitton et al.   Marine Drugs

Paraneoplastic thrombocytosis: the secrets of tumor self-promotion

(2014) R. J. Lin et al.   BLOOD

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Heteromultivalent liposomal nanoconstructs for enhanced targeting and shear-stable binding to active platelets for site-selective vascular drug delivery

(2011) Christa L. Modery et al.   BIOMATERIALS

Host Response to Short-term, Single-Agent Chemotherapy Induces Matrix Metalloproteinase-9 Expression and Accelerates Metastasis in Mice

(2011) S. Gingis-Velitski et al.   CANCER RESEARCH

Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

(2011) F. Rouzet et al.   JOURNAL OF NUCLEAR MEDICINE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS)

(2008) C. Ay et al.   BLOOD

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE

Metastasis: a therapeutic target for cancer

(2008) Patricia S Steeg et al.   Nature clinical practice. Oncology