Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients

Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling

(2022) Xiaodan Zhang et al.   Cell Death & Disease

Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary

(2022) Yanlong Song et al.   Frontiers in Cell and Developmental Biology

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators

(2022) Ellen Youngsoo Rim et al.   Annual Review of Biochemistry

Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice

(2022) Yanli Dai et al.   BMC BIOLOGY

Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription

(2022) Alexander Wirth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage

(2022) Miao Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation

(2022) Yu-Ying Chen et al.   REPRODUCTION

Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis

(2022) Bethany F. Campbell et al.   TRAFFIC

Molecular Mechanisms of AMH Signaling

(2022) James A. Howard et al.   Frontiers in Endocrinology

Heterozygous loss-of-function variants in LHX8 cause female infertility characterized by oocyte maturation arrest

(2022) Lin Zhao et al.   GENETICS IN MEDICINE

WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility

(2021) Okiko Habara et al.   DEVELOPMENT

In vitro growth and maturation of primordial follicles and immature oocytes

(2021) Evelyn E. Telfer et al.   FERTILITY AND STERILITY

Autotransplantation of the ovarian cortex after in-vitro activation for infertility treatment: a shortened procedure

(2021) Ling Zhang et al.   HUMAN REPRODUCTION

AMH Is a Good Predictor of Metabolic Risk in Women with PCOS: A Cross-Sectional Study

(2021) Miaoxian Ou et al.   International Journal of Endocrinology

HDAC6 regulates primordial follicle activation through mTOR signaling pathway

(2021) Tuo Zhang et al.   Cell Death & Disease

The Crazy Ovary

(2021) Philippe Monget et al.   Genes

Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles

(2021) Yu Zhao et al.   Cells

Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS

(2021) Ewa Rudnicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis

(2021) Anna Heinrich et al.   Cell Reports

A gatekeeping role of ESR2 to maintain the primordial follicle reserve

(2020) V Praveen Chakravarthi et al.   ENDOCRINOLOGY

FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation

(2020) Zhengpin Wang et al.   NUCLEIC ACIDS RESEARCH

Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing

(2020) Mila Maidarti et al.   Cells

p27 as a transcriptional regulator: New roles in development and cancer

(2020) Seyedeh Fatemeh Razavipour et al.   CANCER RESEARCH

R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth

(2020) Marie-Cécile De Cian et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 and aging related signaling pathways

(2020) Cui Chen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hippo signaling disruption and ovarian follicle activation in infertile patients

(2020) Aaron J.W. Hsueh et al.   FERTILITY AND STERILITY

CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice

(2020) Jia Li et al.   HISTOCHEMISTRY AND CELL BIOLOGY

HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions

(2020) Alexis Osseni et al.   JOURNAL OF CELL BIOLOGY

Anti-Müllerian hormone and ovarian reserve: update on assessing ovarian function

(2020) Loes M E Moolhuijsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HDAC6 Mediates Poly (I:C)-Induced TBK1 and Akt Phosphorylation in Macrophages

(2020) Yan Wang et al.   Frontiers in Immunology

Surgical approaches of drug-free in vitro activation and laparoscopic ovarian incision to treat patients with ovarian infertility

(2020) Yuka Tanaka et al.   FERTILITY AND STERILITY

Loss of anti-Müllerian hormone (AMH) immunoactivity due to a homozygous AMH gene variant rs10417628 in a woman with classical polycystic ovary syndrome (PCOS)

(2020) Luis R Hoyos et al.   HUMAN REPRODUCTION

Transcriptional changes of mouse ovary during follicle initial or cyclic recruitment mediated by extra hormone treatment

(2020) Xuejiao Bian et al.   LIFE SCIENCES

Hippo Signaling in Embryogenesis and Development

(2020) Zhengming Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

(2020) Stefano Pierini et al.   JCI Insight

In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human

(2020) Jiawei Zhang et al.   Clinical and Translational Medicine

Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice

(2019) Hao Yan et al.   Cell Death & Disease

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex

(2019) Catherine L. Salussolia et al.   Annual Review of Genomics and Human Genetics

Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines

(2019) Helena Teede et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles

(2019) Sofia Granados-Aparici et al.   Scientific Reports

The Clinical Spectrum of PTEN Mutations

(2019) Lamis Yehia et al.   Annual Review of Medicine

Estrogen-Receptor Expression and Function in Female Reproductive Disease

(2019) Zi-Run Tang et al.   Cells

The mTOR Pathway in Reproduction: From Gonadal Function to Developmental Coordination

(2019) Bibiana Correia et al.   REPRODUCTION

SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription

(2019) Tuo Zhang et al.   FASEB JOURNAL

Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage†

(2018) Laura D’Ignazio et al.   BIOLOGY OF REPRODUCTION

CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes

(2018) Hao Yan et al.   BMC BIOLOGY

The role of mTOR in ovarian cancer, polycystic ovary syndrome and ovarian aging

(2018) Jin Liu et al.   CLINICAL ANATOMY

Dynamics of PI3K and Hippo signaling pathways during in vitro human follicle activation

(2018) J Grosbois et al.   HUMAN REPRODUCTION

Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

(2018) Jing Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies

(2018) Michael J. Bertoldo et al.   REPRODUCTIVE BIOMEDICINE ONLINE

PDK1: At the crossroad of cancer signaling pathways

(2018) Paolo Armando Gagliardi et al.   SEMINARS IN CANCER BIOLOGY

Untapped Reserves: Controlling Primordial Follicle Growth Activation

(2018) Amanda Kallen et al.   TRENDS IN MOLECULAR MEDICINE

TGF-β receptors: In and beyond TGF-β signaling

(2018) Alexandra Vander Ark et al.   CELLULAR SIGNALLING

AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice

(2018) Charlotte Sonigo et al.   FASEB JOURNAL

Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

(2018) F. Fabregues et al.   Journal of Ovarian Research

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

(2018) Ruoxi Wang et al.   JOURNAL OF CELL BIOLOGY

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT1 knock-in mice preserve ovarian reserve resembling caloric restriction

(2018) Guan-Yun Long et al.   GENE

MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling

(2017) Yu Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27 Kip1 promoter in primordial follicles

(2017) Hoon Jang et al.   JOURNAL OF PINEAL RESEARCH

Changes in E-cadherin rigidity sensing regulate cell adhesion

(2017) Caitlin Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway

(2017) Yuanlin He et al.   Cell Death & Disease

Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals

(2017) Wei Liu et al.   Cell Death & Disease

Overexpression of Hdac6 extends reproductive lifespan in mice

(2017) Xiaoxi Zhang et al.   Protein & Cell

In Vitro Activation: A Dip Into the Primordial Follicle Pool?

(2016) Ophelia Yin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

In Vitro Activation of Follicles and Fresh Tissue Auto-transplantation in Primary Ovarian Insufficiency Patients

(2016) Jun Zhai et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice

(2016) Lihua Zhao et al.   Scientific Reports

Control of Oocyte Reawakening by Kit

(2016) Hatice Duygu Saatcioglu et al.   PLoS Genetics

Lhx8 regulates primordial follicle activation and postnatal folliculogenesis

(2015) Yu Ren et al.   BMC BIOLOGY

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators

(2015) Xinhui Sun et al.   CELL CYCLE

Intraovarian Control of Early Folliculogenesis

(2015) Aaron J. W. Hsueh et al.   ENDOCRINE REVIEWS

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

(2015) Hua Zhang et al.   HUMAN REPRODUCTION UPDATE

Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary

(2015) M. Max Ezzati et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

(2015) Hua Zhang et al.   NATURE MEDICINE

PTEN

(2014) Carolyn A. Worby et al.   Annual Review of Biochemistry

Epidermal Growth Factor (EGF) Sustains In Vitro Primordial Follicle Viability by Enhancing Stromal Cell Proliferation via MAPK and PI3K Pathways in the Prepubertal, but Not Adult, Cat Ovary1

(2014) Mayako Fujihara et al.   BIOLOGY OF REPRODUCTION

Somatic Cells Initiate Primordial Follicle Activation and Govern the Development of Dormant Oocytes in Mice

(2014) Hua Zhang et al.   CURRENT BIOLOGY

Loss ofNtrk2/Kiss1rSignaling in Oocytes Causes Premature Ovarian Failure

(2014) Mauricio D. Dorfman et al.   ENDOCRINOLOGY

The physiology and clinical utility of anti-Müllerian hormone in women

(2014) Didier Dewailly et al.   HUMAN REPRODUCTION UPDATE

Transforming Growth Factor-β Signaling Participates in the Maintenance of the Primordial Follicle Pool in the Mouse Ovary

(2014) Zheng-Pin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of nerve growth factor and its receptors in tumorigenesis and cancer pain

(2014) Wenfang Wang et al.   BioScience Trends

Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions

(2013) Wenjing Zheng et al.   HUMAN MOLECULAR GENETICS

Cadherin adhesome at a glance

(2013) R. Zaidel-Bar   JOURNAL OF CELL SCIENCE

FOXL2: a central transcription factor of the ovary

(2013) Adrien Georges et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

(2013) K. Kawamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

(2012) Hongwei Yao et al.   BIOCHEMICAL PHARMACOLOGY

R-spondins are involved in the ovarian differentiation in a teleost, medaka (Oryzias latipes)

(2012) Linyan Zhou et al.   BMC DEVELOPMENTAL BIOLOGY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates in Mice1

(2011) Lindsey Mork et al.   BIOLOGY OF REPRODUCTION

Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase

(2011) Bérénice A. Benayoun et al.   HUMAN MOLECULAR GENETICS

mTOR signaling in the control of activation of primordial follicles

(2010) Deepak Adhikari et al.   CELL CYCLE

Nerve Growth Factor Promotes the Survival of Goat Preantral Follicles Cultured in vitro

(2010) R.N. Chaves et al.   CELLS TISSUES ORGANS

Primary ovarian insufficiency

(2010) Michel De Vos et al.   LANCET

Activation of dormant ovarian follicles to generate mature eggs

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

(2009) Deepak Adhikari et al.   ENDOCRINE REVIEWS

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles

(2009) Pradeep Reddy et al.   HUMAN MOLECULAR GENETICS

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

Primary Ovarian Insufficiency

(2009) Lawrence M. Nelson   NEW ENGLAND JOURNAL OF MEDICINE

NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary

(2009) Bredford Kerr et al.   REPRODUCTION

Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

(2009) Pradeep Reddy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lim Homeobox Gene, Lhx8, Is Essential for Mouse Oocyte Differentiation and Survival1

(2008) Youngsok Choi et al.   BIOLOGY OF REPRODUCTION

R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation

(2008) Ayhan Kocer et al.   BMC DEVELOPMENTAL BIOLOGY

The epidermal growth factor receptor ligands at a glance

(2008) Marlon R. Schneider et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE