FOXL2: a central transcription factor of the ovary

MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2

(2013) Anyi Dai et al.   FEBS LETTERS

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Differentiation of Human Embryonic Stem Cells Into Functional Ovarian Granulosa-like Cells

(2013) Chen-Wei Lan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells

(2013) Kirsten J. McTavish et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434

(2013) David Nonis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Impaired Fertility and FSH Synthesis in Gonadotrope-SpecificFoxl2Knockout Mice

(2013) Stella Tran et al.   MOLECULAR ENDOCRINOLOGY

Overexpression of Wild-Type but Not C134W Mutant FOXL2 Enhances GnRH-Induced Cell Apoptosis by Increasing GnRH Receptor Expression in Human Granulosa Cell Tumors

(2013) Jung-Chien Cheng et al.   PLoS One

Embryonic Stem Cell–Derived Granulosa Cells Participate in Ovarian Follicle Formation In Vitro and In Vivo

(2013) Dori C. Woods et al.   Reproductive Sciences

FOXL2Mutations in Granulosa Cell Tumors Occurring in Males

(2012) Joema F. Lima et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

A Fox stops the Wnt: implications for forebrain development and diseases

(2012) Catherine Danesin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Molecular Pathogenesis of Granulosa Cell Tumors of the Ovary

(2012) Stacey Jamieson et al.   ENDOCRINE REVIEWS

FOXL2 Is Involved in the Synergy between Activin and Progestins on the Follicle-Stimulating Hormone β-Subunit Promoter

(2012) Yasmin Ghochani et al.   ENDOCRINOLOGY

Mutational screening of SF1 and WNT4 in Tunisian women with premature ovarian failure

(2012) Besma Lakhal et al.   GENE

Comparative study of microRNA regulation on FOXL2 between adult-type and juvenile-type granulosa cell tumours in vitro

(2012) Roseanne Rosario et al.   GYNECOLOGIC ONCOLOGY

FOXL2 Impairment in Human Disease

(2012) Hannah Verdin et al.   Hormone Research in Paediatrics

Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles

(2012) David L'Hôte et al.   HUMAN MOLECULAR GENETICS

Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation

(2012) B A Benayoun et al.   ONCOGENE

The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours

(2012) Roseanne Rosario et al.   PLoS One

Mutant Forkhead L2 (FOXL2) Proteins Associated with Premature Ovarian Failure (POF) Dimerize with Wild-Type FOXL2, Leading to Altered Regulation of Genes Associated with Granulosa Cell Differentiation

(2011) Fang-Ting Kuo et al.   ENDOCRINOLOGY

Minireview: Roles of the Forkhead Transcription Factor FOXL2 in Granulosa Cell Biology and Pathology

(2011) Margareta D. Pisarska et al.   ENDOCRINOLOGY

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

Nuclear localization of E-cadherin but not beta-catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stroma

(2011) Yoshihiro Ohishi et al.   HISTOPATHOLOGY

Mutational probing of the forkhead domain of the transcription factor FOXL2 provides insights into the pathogenicity of naturally occurring mutations

(2011) Anne-Laure Todeschini et al.   HUMAN MOLECULAR GENETICS

The transcription factor FOXL2: At the crossroads of ovarian physiology and pathology

(2011) Sandrine Caburet et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Impaired FSHβ Expression in the Pituitaries ofFoxl2Mutant Animals

(2011) Nicholas J. Justice et al.   MOLECULAR ENDOCRINOLOGY

SMADs and FOXL2 Synergistically Regulate Murine FSHβ Transcription Via a Conserved Proximal Promoter Element

(2011) Stella Tran et al.   MOLECULAR ENDOCRINOLOGY

DMRT1 prevents female reprogramming in the postnatal mammalian testis

(2011) Clinton K. Matson et al.   NATURE

Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis

(2011) J S Richards et al.   ONCOGENE

SUMOylation of the Forkhead Transcription Factor FOXL2 Promotes Its Stabilization/Activation through Transient Recruitment to PML Bodies

(2011) Adrien Georges et al.   PLoS One

Loss of R-Spondin1 and Foxl2 Amplifies Female-to-Male Sex Reversal in XX Mice

(2011) A. Auguste et al.   Sexual Development

LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity

(2010) Margareta D. Pisarska et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activin A Regulates Porcine Follicle-Stimulating Hormone β-Subunit Transcription via Cooperative Actions of SMADs and FOXL2

(2010) Pankaj Lamba et al.   ENDOCRINOLOGY

FOXL2 and BMP2 Act Cooperatively to RegulateFollistatinGene Expression during Ovarian Development

(2010) Kenichi Kashimada et al.   ENDOCRINOLOGY

The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary

(2010) Stacey Jamieson et al.   MODERN PATHOLOGY

FOXL2 Interacts with Steroidogenic Factor-1 (SF-1) and Represses SF-1-InducedCYP17Transcription in Granulosa Cells

(2010) Mira Park et al.   MOLECULAR ENDOCRINOLOGY

Granulosa Cell-Expressed BMPR1A and BMPR1B Have Unique Functions in Regulating Fertility but Act Redundantly to Suppress Ovarian Tumor Development

(2010) Mark A. Edson et al.   MOLECULAR ENDOCRINOLOGY

FoxL2 Is Required for Activin Induction of the Mouse and Human Follicle-Stimulating Hormone β-Subunit Genes

(2010) Patrick S. Corpuz et al.   MOLECULAR ENDOCRINOLOGY

Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W)

(2010) J-H Kim et al.   ONCOGENE

The Forkhead Transcription Factor Foxl2 Is Sumoylated in Both Human and Mouse: Sumoylation Affects Its Stability, Localization, and Activity

(2010) Mara Marongiu et al.   PLoS One

Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)

(2010) Bérénice A. Benayoun et al.   PLoS One

Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

(2010) Nicholas I. Fleming et al.   PLoS One

Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

(2010) Jean M Escudero et al.   Journal of Ovarian Research

Foxl2 functions in sex determination and histogenesis throughout mouse ovary development

(2009) José Garcia-Ortiz et al.   BMC DEVELOPMENTAL BIOLOGY

Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation

(2009) N. Henriette Uhlenhaut et al.   CELL

Sumoylation of Forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene

(2009) Fang-Ting Kuo et al.   CELLULAR SIGNALLING

FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation

(2009) Ryuji Hiramatsu et al.   DEVELOPMENT

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

(2009) Deepak Adhikari et al.   ENDOCRINE REVIEWS

The Mammalian Ovary from Genesis to Revelation

(2009) Mark A. Edson et al.   ENDOCRINE REVIEWS

Foxl2, a Forkhead Transcription Factor, Modulates Nonclassical Activity of the Estrogen Receptor-α

(2009) So-Youn Kim et al.   ENDOCRINOLOGY

Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2

(2009) Ikuko K. Bentsi-Barnes et al.   FERTILITY AND STERILITY

Towards a functional classification of pathogenic FOXL2 mutations using transactivation reporter systems

(2009) Aurélie Dipietromaria et al.   HUMAN MOLECULAR GENETICS

Gonadal defects in Cited2 -mutant mice indicate a role for SF1 in both testis and ovary differentiation

(2009) Alexander N. Combes et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Retinoblastoma protein: a central processing unit

(2009) M. Poznic   JOURNAL OF BIOSCIENCES

A Novel Role for the Forkhead Transcription Factor FOXL2 in Activin A-Regulated Follicle-Stimulating Hormone β Subunit Transcription

(2009) Pankaj Lamba et al.   MOLECULAR ENDOCRINOLOGY

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

(2009) Sohrab P. Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression1

(2008) Youngsok Choi et al.   BIOLOGY OF REPRODUCTION

Lim Homeobox Gene, Lhx8, Is Essential for Mouse Oocyte Differentiation and Survival1

(2008) Youngsok Choi et al.   BIOLOGY OF REPRODUCTION

A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

(2008) Yoko Miyamoto et al.   BMC MOLECULAR BIOLOGY

Ovarian development in mice requires the GATA4-FOG2 transcription complex

(2008) N. L. Manuylov et al.   DEVELOPMENT

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth

(2008) George B. John et al.   DEVELOPMENTAL BIOLOGY

Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations

(2008) Bérénice A. Benayoun et al.   HUMAN MOLECULAR GENETICS

Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

(2008) Danielle M. Maatouk et al.   HUMAN MOLECULAR GENETICS

Sex-specific roles of  -catenin in mouse gonadal development

(2008) C.-F. Liu et al.   HUMAN MOLECULAR GENETICS

Activation of  -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

(2008) A.-A. Chassot et al.   HUMAN MOLECULAR GENETICS

Human SRY inhibits β-catenin-mediated transcription

(2008) Pascal Bernard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

FoxL2 and Smad3 Coordinately Regulate Follistatin Gene Transcription

(2008) Amy L. Blount et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditional Deletion of the Retinoblastoma (Rb) Gene in Ovarian Granulosa Cells Leads to Premature Ovarian Failure

(2008) Claudia Andreu-Vieyra et al.   MOLECULAR ENDOCRINOLOGY

FOXO-binding partners: it takes two to tango

(2008) K E van der Vos et al.   ONCOGENE

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE

Attempt to Rescue Sex-Reversal by Transgenic Expression of the PISRT1 Gene in XX PIS–/– Goats

(2008) L. Boulanger et al.   Sexual Development