SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription

CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes

(2018) Hao Yan et al.   BMC BIOLOGY

Resveratrol improves in vitro maturation of oocytes in aged mice and humans

(2018) Mei-Ju Liu et al.   FERTILITY AND STERILITY

Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

(2018) Carla Tatone et al.   HUMAN REPRODUCTION UPDATE

SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity

(2018) Shigeru Suzuki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

(2018) Jing Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol promotes in vitro activation of ovine primordial follicles by reducing DNA damage and enhancing granulosa cell proliferation via phosphatidylinositol 3-kinase pathway

(2018) Maria Éllida S. Bezerra et al.   REPRODUCTION IN DOMESTIC ANIMALS

SIRT1 knock-in mice preserve ovarian reserve resembling caloric restriction

(2018) Guan-Yun Long et al.   GENE

Recent advances in the field of ovarian tissue cryopreservation and opportunities for research

(2017) Camille Ladanyi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation

(2017) Mei Zhang et al.   Cell Death & Disease

Activation of dormant follicles

(2016) Kazuhiro Kawamura et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice

(2016) Chao Liu et al.   DEVELOPMENT

In Vitro Activation: A Dip Into the Primordial Follicle Pool?

(2016) Ophelia Yin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

In Vitro Activation of Follicles and Fresh Tissue Auto-transplantation in Primary Ovarian Insufficiency Patients

(2016) Jun Zhai et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

In Vitro Activation

(2016) Christina N. Cordeiro et al.   Reproductive Sciences

New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators

(2015) Xinhui Sun et al.   CELL CYCLE

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

(2015) Duanfang Cao et al.   GENES & DEVELOPMENT

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

(2015) Hua Zhang et al.   HUMAN REPRODUCTION UPDATE

Genetics of primary ovarian insufficiency: new developments and opportunities

(2015) Yingying Qin et al.   HUMAN REPRODUCTION UPDATE

Somatic Cells Initiate Primordial Follicle Activation and Govern the Development of Dormant Oocytes in Mice

(2014) Hua Zhang et al.   CURRENT BIOLOGY

SirT1 is required in the male germ cell for differentiation and fecundity in mice

(2014) E. L. Bell et al.   DEVELOPMENT

mTORC1 Signaling in Oocytes Is Dispensable for the Survival of Primordial Follicles and for Female Fertility

(2014) Nagaraju Gorre et al.   PLoS One

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

(2014) Xiao-Ling Zhou et al.   Journal of Ovarian Research

Resveratrol protects against age-associated infertility in mice

(2013) Mengyuan Liu et al.   HUMAN REPRODUCTION

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

(2013) K. Kawamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

(2012) Deepak Adhikari et al.   PLoS One

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

(2011) Erin L. Seifert et al.   FASEB JOURNAL

Resumption of Ovarian Function and Pregnancies in 358 Patients with Premature Ovarian Failure

(2011) Maud Bidet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation of dormant ovarian follicles to generate mature eggs

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

(2009) Deepak Adhikari et al.   ENDOCRINE REVIEWS

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles

(2009) Pradeep Reddy et al.   HUMAN MOLECULAR GENETICS

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE