Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity

(2022) Tsubasa Sakurai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks

(2021) Daniel T. Pederick et al.   SCIENCE

Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

(2020) Daniel del Toro et al.   CELL

Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats

(2020) Samantha L. Regan et al.   ACS Chemical Neuroscience

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126)

(2020) Enric Lizano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation

(2019) Niall Mortimer et al.   NEUROPHARMACOLOGY

Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily

(2019) Ana L. Moreno-Salinas et al.   Frontiers in Neuroscience

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

(2019) Samantha L. Regan et al.   NEUROBIOLOGY OF DISEASE

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

(2016) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Behavioral and transcriptomic profiling of mice null forLphn3, a gene implicated in ADHD and addiction

(2016) Caitlin A. Orsini et al.   Molecular Genetics & Genomic Medicine

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila

(2015) M van der Voet et al.   MOLECULAR PSYCHIATRY

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

(2015) Yue C. Lu et al.   STRUCTURE

Structural Basis of Latrophilin-FLRT Interaction

(2015) Verity A. Jackson et al.   STRUCTURE

Constant pressure and temperature discrete-time Langevin molecular dynamics

(2014) Niels Grønbech-Jensen et al.   JOURNAL OF CHEMICAL PHYSICS

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

High-throughput Functional Screening using a Homemade Dual-glow Luciferase Assay

(2014) Jessica M. Baker et al.   Jove-Journal of Visualized Experiments

Initial characterization of mice null for Lphn3 , a gene implicated in ADHD and addiction

(2012) Deeann Wallis et al.   BRAIN RESEARCH

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

The ADHD-linked gene Lphn3.1 controls locomotor activity and impulsivity in zebrafish

(2012) M Lange et al.   MOLECULAR PSYCHIATRY

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

(2012) Matthew L. O'Sullivan et al.   NEURON

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities

(2011) J.-P. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

(2009) Bettye Hollins et al.   CELLULAR SIGNALLING