Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies

(2022) Kwok-ho Lam et al.   PLoS Pathogens

Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E

(2021) Geoffrey Masuyer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

(2020) Kwok-ho Lam et al.   Cell Reports

Global view of human protein glycosylation pathways and functions

(2020) Katrine T. Schjoldager et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

(2020) Jacqueline M. Tremblay et al.   Toxins

Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells

(2020) Kwok-Ho Lam et al.   Toxins

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models

(2019) Mark Elliott et al.   Science Advances

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

(2019) Emma K. Persson et al.   SCIENCE

Botulinum neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations

(2019) Sabine Pellett et al.   FEBS LETTERS

Safety and pharmacodynamics of a novel recombinant botulinum toxin E (rBoNT-E): Results of a phase 1 study in healthy male subjects compared with abobotulinumtoxinA (Dysport®)

(2019) Laurent Pons et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Structural insights into the interaction of botulinum neurotoxin a with its neuronal receptor SV2C

(2019) Xiaodan Li et al.   TOXICON

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding

(2018) Robert Gustafsson et al.   Toxins

The Expanding Therapeutic Utility of Botulinum Neurotoxins

(2018) Elena Fonfria et al.   Toxins

Botulinum and Tetanus Neurotoxins

(2018) Min Dong et al.   Annual Review of Biochemistry

Safety and Efficacy of EB-001, a Novel Type E Botulinum Toxin, in Subjects with Glabellar Frown Lines

(2018) Steve G. Yoelin et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

(2017) Marco Pirazzini et al.   PHARMACOLOGICAL REVIEWS

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

(2017) Liang Tao et al.   Nature Communications

Puzzling Out Synaptic Vesicle 2 Family Members Functions

(2017) Odile Bartholome et al.   Frontiers in Molecular Neuroscience

Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C

(2017) Roger M. Benoit et al.   Scientific Reports

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding

(2017) Guorui Yao et al.   Scientific Reports

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1

(2016) S. Mahrhold et al.   BIOCHEMICAL JOURNAL

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

(2016) Jasmin Weisemann et al.   Toxins

Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery

(2015) Kwok-Ho Lam et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin

(2015) Kwok-Ho Lam et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)

(2015) Hans Bigalke et al.   Toxins

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test

(2015) Jasmin Weisemann et al.   Toxins

Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

(2014) K. A. Weedmark et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

(2014) Jasmin Strotmeier et al.   FEBS LETTERS

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Engineered Botulinum Neurotoxins as New Therapeutics

(2013) Geoffrey Masuyer et al.   Annual Review of Pharmacology and Toxicology

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E

(2013) Stefan Mahrhold et al.   BIOCHEMICAL JOURNAL

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

(2013) Roger M. Benoit et al.   NATURE

Structure of dual receptor binding to botulinum neurotoxin B

(2013) Ronnie P-A. Berntsson et al.   Nature Communications

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

(2013) Laura Restani et al.   PLoS Pathogens

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

(2013) Kwangkook Lee et al.   PLoS Pathogens

Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells

(2012) Amelie Croset et al.   JOURNAL OF BIOTECHNOLOGY

Human cells: New platform for recombinant therapeutic protein production

(2012) Kamilla Swiech et al.   PROTEIN EXPRESSION AND PURIFICATION

Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex

(2012) S. Gu et al.   SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

(2011) Lisheng Peng et al.   PLoS Pathogens

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

(2010) J. V. Chakkalakal et al.   DEVELOPMENT

SV2 Mediates Entry of Tetanus Neurotoxin into Central Neurons

(2010) Felix L. Yeh et al.   PLoS Pathogens

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

(2009) Zhuji Fu et al.   BIOCHEMISTRY

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

(2009) Andreas Rummel et al.   JOURNAL OF NEUROCHEMISTRY

Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics

(2008) Jiafu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation

(2008) Desigan Kumaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

(2008) Pål Stenmark et al.   PLoS Pathogens