The Expanding Therapeutic Utility of Botulinum Neurotoxins

The role of TGFβ in wound healing pathologies

(2018) Dimitra Kiritsi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Osteoarthritis year in review 2017: clinical

(2018) A.E. Nelson   OSTEOARTHRITIS AND CARTILAGE

Direct central nervous system effects of botulinum neurotoxin

(2018) Matteo Caleo et al.   TOXICON

Intravesical Electromotive Botulinum Toxin Type “A” Administration for Management of Urinary Incontinence Secondary to Neuropathic Detrusor Overactivity in Children: Long-term Follow-up

(2018) Seyedeh-Sanam Ladi-Seyedian et al.   UROLOGY

Early experimental results of using a novel delivery carrier, hyaluronan-phosphatidylethanolamine (HA-PE), which may allow simple bladder instillation of botulinum toxin A as effectively as direct detrusor muscle injection

(2018) Mohamed Galal El Shatoury et al.   Journal of Pediatric Urology

Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region

(2017) V. Drinovac Vlah et al.   EUROPEAN JOURNAL OF PAIN

Adaptive changes of telocytes in the urinary bladder of patients affected by neurogenic detrusor overactivity

(2017) Chiara Traini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Past, Present and Future of Chemodenervation with Botulinum Toxin in the Treatment of Overactive Bladder

(2017) Pradeep Tyagi et al.   JOURNAL OF UROLOGY

Botulinum neurotoxin type A-cleaved SNAP25 is confined to primary motor neurons and localized on the plasma membrane following intramuscular toxin injection

(2017) Brian B. Cai et al.   NEUROSCIENCE

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

(2017) Marco Pirazzini et al.   PHARMACOLOGICAL REVIEWS

Design of modified botulinum neurotoxin A1 variants with a shorter persistence of paralysis and duration of action

(2017) Daniel Scheps et al.   TOXICON

Intra-articular injection of Botulinum toxin A reduces neurogenic inflammation in CFA-induced arthritic rat model

(2017) Lin Wang et al.   TOXICON

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

(2017) Liang Tao et al.   Nature Communications

Identification and characterization of a novel botulinum neurotoxin

(2017) Sicai Zhang et al.   Nature Communications

Liquid Formulation of AbobotulinumtoxinA Exhibits a Favorable Efficacy and Safety Profile in Moderate to Severe Glabellar Lines: A Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trial

(2017) Benjamin Ascher et al.   Aesthetic Surgery Journal

A systematic review and meta-analysis of effectiveness and safety of therapy for overactive bladder using botulinum toxin A at different dosages

(2017) Hui-Yun Gu et al.   Oncotarget

Molecular Mechanisms That Contribute to Bone Marrow Pain

(2017) Jason J. Ivanusic   Frontiers in Neurology

Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C

(2017) Roger M. Benoit et al.   Scientific Reports

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain

(2016) Magdalena Zychowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impairment of sensory afferents by intrathecal administration of botulinum toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats

(2016) Ana Coelho et al.   EXPERIMENTAL NEUROLOGY

Entry of Botulinum Neurotoxin Subtypes A1 and A2 into Neurons

(2016) Abby R. Kroken et al.   INFECTION AND IMMUNITY

Intravesical electromotive botulinum toxin type A administration for management of concomitant neuropathic bowel and bladder dysfunction in children

(2016) Abdol-Mohammad Kajbafzadeh et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Usefulness of intra-articular botulinum toxin injections. A systematic review

(2016) Hichem Khenioui et al.   JOINT BONE SPINE

Botulinum toxin type A in motor nervous system: unexplained observations and new challenges

(2016) I. Matak et al.   JOURNAL OF NEURAL TRANSMISSION

Urodynamic and Immunohistochemical Evaluation of Intravesical Botulinum Toxin A Delivery Using Low Energy Shock Waves

(2016) Yao-Chi Chuang et al.   JOURNAL OF UROLOGY

Receptors, channels and signalling in the urothelial sensory system in the bladder

(2016) Liana Merrill et al.   Nature Reviews Urology

Practice guideline update summary: Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache

(2016) David M. Simpson et al.   NEUROLOGY

Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain

(2016) L Arendt-Nielsen et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons

(2016) Ewa Bomba-Warczak et al.   Cell Reports

Effects of Botulinum Toxin Landmark-Guided Intra-articular Injection in Subjects With Knee Osteoarthritis

(2016) Lin-Fen Hsieh et al.   PM&R

Botulinum Toxin A and Lower Urinary Tract Dysfunction: Pathophysiology and Mechanisms of Action

(2016) Jia-Fong Jhang et al.   Toxins

Intravesical instillation of onabotulinum toxin A embedded in inert hydrogel in the treatment of idiopathic overactive bladder: A double-blind randomized pilot study

(2016) Jan Krhut et al.   Scandinavian Journal of Urology

Expression and purification of recombinant TAT-BoNT/A(1–448) under denaturing and native conditions

(2016) Parvaneh Saffarian et al.   Bioengineered

Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia

(2016) Chuanjie Wu et al.   SpringerPlus

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles

(2016) Callista B. Harper et al.   Scientific Reports

TAT-BoNT/A(1–448), a novel fusion protein as a therapeutic agent: analysis of transcutaneous delivery and enzyme activity

(2015) Parvaneh Saffarian et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Activity of botulinum toxin type A in cranial dura: implications for treatment of migraine and other headaches

(2015) Zdravko Lacković et al.   BRITISH JOURNAL OF PHARMACOLOGY

Botulinum neurotoxin type A modulates vesicular release of glutamate from satellite glial cells

(2015) Larissa Bittencourt da Silva et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Control of Autophagosome Axonal Retrograde Flux by Presynaptic Activity Unveiled Using Botulinum Neurotoxin Type A

(2015) Tong Wang et al.   JOURNAL OF NEUROSCIENCE

Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents

(2015) Roshni Ramachandran et al.   NEUROBIOLOGY OF DISEASE

Dynamic cortical gray matter volume changes after botulinum toxin in cervical dystonia

(2015) Cathérine C.S. Delnooz et al.   NEUROBIOLOGY OF DISEASE

Clinical differences between A1 and A2 botulinum toxin subtypes

(2015) Ryuji Kaji   TOXICON

In vivo onset and duration of action varies for botulinum neurotoxin A subtypes 1-5

(2015) Sabine Pellett et al.   TOXICON

The long journey of botulinum neurotoxins into the synapse

(2015) Andreas Rummel   TOXICON

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

(2015) S. Vilhegas et al.   VETERINARY RECORD

Botulinum toxin for the prevention and healing of wound scars: A systematic review of the literature

(2015) Anastasia Prodromidou et al.   Plastic Surgery

Comparison of Systemic Toxicity between Botulinum Toxin Subtypes A1 and A2 in Mice and Rats

(2014) Yasushi Torii et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinson’s disease model

(2014) Masanori Itakura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Per cent of patients with chronic migraine who responded per onabotulinumtoxinA treatment cycle: PREEMPT

(2014) Stephen D Silberstein et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Bladder Instillation of Liposome Encapsulated OnabotulinumtoxinA Improves Overactive Bladder Symptoms: A Prospective, Multicenter, Double-Blind, Randomized Trial

(2014) Yao-Chi Chuang et al.   JOURNAL OF UROLOGY

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

More than at the Neuromuscular Synapse

(2014) Riccardo Mazzocchio et al.   NEUROSCIENTIST

Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of “Overactive bladder”

(2014) Christopher Chapple   NEUROUROLOGY AND URODYNAMICS

Persistence of Botulinum Neurotoxin A Subtypes 1-5 in Primary Rat Spinal Cord Cells

(2014) Regina Clare Meyer Whitemarsh et al.   PLoS One

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Comparison between botulinum neurotoxin type A2 and type A1 by electrophysiological study in healthy individuals

(2014) Yohei Mukai et al.   TOXICON

Intra-articular botulinum toxin A for the treatment of osteoarthritic joint pain in dogs: A randomized, double-blinded, placebo-controlled clinical trial

(2014) H.M. Heikkilä et al.   VETERINARY JOURNAL

A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis

(2014) Tommaso Iannitti et al.   Drug Design Development and Therapy

Spinal Central Effects of Peripherally Applied Botulinum Neurotoxin A in Comparison between Its Subtypes A1 and A2

(2014) Hidetaka Koizumi et al.   Frontiers in Neurology

OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium

(2013) Valerie M. Collins et al.   BJU INTERNATIONAL

Characterization of Botulinum Neurotoxin A Subtypes 1 Through 5 by Investigation of Activities in Mice, in Neuronal Cell Cultures, andIn Vitro

(2013) Regina C. M. Whitemarsh et al.   INFECTION AND IMMUNITY

Diffusion, spread, and migration of botulinum toxin

(2013) Juan Ramirez-Castaneda et al.   MOVEMENT DISORDERS

Anti-inflammatory Effects of Botulinum Toxin Type A in a Complete Freund’s Adjuvant-Induced Arthritic Knee Joint of Hind Leg on Rat Model

(2013) Ki Yeon Yoo et al.   NEUROTOXICITY RESEARCH

Comparison of the immunogenicity of botulinum toxin type A and the efficacy of A1 and A2 neurotoxins in animals with A1 toxin antibodies

(2013) Yasushi Torii et al.   TOXICON

Content of Botulinum Neurotoxin in Botox®/Vistabel®, Dysport®/Azzalure®, and Xeomin®/Bocouture®

(2013) Jürgen Frevert   Drugs in research & development

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

(2013) Laura Restani et al.   PLoS Pathogens

A Novel Botulinum Neurotoxin Topical Gel: Treatment of Allergic Rhinitis in Rats and Comparative Safety Profile

(2012) Zhao Zhu et al.   American Journal of Rhinology & Allergy

Purification and Characterization of a Novel Subtype A3 Botulinum Neurotoxin

(2012) William H. Tepp et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity

(2012) Jasmin Strotmeier et al.   FEBS LETTERS

Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

(2012) Lisheng Peng et al.   JOURNAL OF CELL SCIENCE

Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin

(2012) B.M. Torrisi et al.   JOURNAL OF CONTROLLED RELEASE

Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury^|^ndash;Induced Neuropathic Pain Models

(2012) Lin Ma et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Beyond muscular effects: depression of spinal recurrent inhibition after botulinum neurotoxin A

(2012) Véronique Marchand-Pauvert et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transsynaptic inhibition of spinal transmission by A2 botulinum toxin

(2012) Norio Akaike et al.   JOURNAL OF PHYSIOLOGY-LONDON

Use of botulinum toxin type A to improve treatment of facial wounds: A prospective randomised study

(2012) Makram Ziade et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

907 EFFECT OF INTRAVESICAL BOTULINUM TOXIN A DELIVERY (USING DMSO) IN RAT OVERACTIVE BLADDER MODEL

(2012) Shogo Shimizu et al.   JOURNAL OF UROLOGY

Botulinum toxin’s axonal transport from periphery to the spinal cord

(2012) Ivica Matak et al.   NEUROCHEMISTRY INTERNATIONAL

OnabotulinumtoxinA for Treatment of Focal Cancer Pain After Surgery and/or Radiation

(2012) Shivam Mittal et al.   PAIN MEDICINE

Onabotulinumtoxin-A intradetrusorial injections modulate bladder expression of NGF, TrkA, p75 and TRPV1 in patients with detrusor overactivity

(2012) Antonella Giannantoni et al.   PHARMACOLOGICAL RESEARCH

Central Action of Peripherally Applied Botulinum Toxin Type A on Pain and Dural Protein Extravasation in Rat Model of Trigeminal Neuropathy

(2012) Boris Filipović et al.   PLoS One

The Analgesic Effect on Neuropathic Pain of Retrogradely Transported botulinum Neurotoxin A Involves Schwann Cells and Astrocytes

(2012) Sara Marinelli et al.   PLoS One

Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat

(2012) Min-Chul Shin et al.   TOXICON

Botulinum Neurotoxin A Impairs Neurotransmission Following Retrograde Transynaptic Transport

(2012) Laura Restani et al.   TRAFFIC

Botulinum Toxin Type A Inhibits Connective Tissue Growth Factor Expression in Fibroblasts Derived From Hypertrophic Scar

(2011) Zhibo Xiao et al.   AESTHETIC PLASTIC SURGERY

Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission

(2011) Gary W. Lawrence et al.   BIOCHEMICAL JOURNAL

Epidemiology of chronic non-cancer pain in Europe: narrative review of prevalence, pain treatments and pain impact

(2011) Kim J. Reid et al.   CURRENT MEDICAL RESEARCH AND OPINION

Microneedles: an emerging transdermal drug delivery system

(2011) Shital H. Bariya et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Development of New Analgesics Over the Past 50 Years: A Lack of Real Breakthrough Drugs

(2010) Igor Kissin   ANESTHESIA AND ANALGESIA

OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial

(2010) SK Aurora et al.   CEPHALALGIA

Efficacy and Safety Evaluation of a Novel Botulinum Toxin Topical Gel for the Treatment of Moderate to Severe Lateral Canthal Lines

(2010) FREDRIC BRANDT et al.   DERMATOLOGIC SURGERY

Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1

(2010) Christina L. Pier et al.   FEBS LETTERS

Spatial Variation of Haemosporidian Parasite Infection in African Rainforest Bird Species

(2010) Claire Loiseau et al.   JOURNAL OF PARASITOLOGY

Overcoming obstacles to developing new analgesics

(2010) Clifford J Woolf   NATURE MEDICINE

Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin

(2010) Nicole M.E. Carmichael et al.   PAIN

Comparison of effects of botulinum toxin subtype A1 and A2 using twitch tension assay and rat grip strength test

(2010) Yasushi Torii et al.   TOXICON

Intravesical Electromotive Botulinum Toxin Type A Administration: Part I—Experimental Study

(2010) Abdol-Mohammad Kajbafzadeh et al.   UROLOGY

Intravesical Electromotive Botulinum Toxin Type A Administration—Part II: Clinical Application

(2010) Abdol-Mohammad Kajbafzadeh et al.   UROLOGY

Bacterial Toxins and the Nervous System: Neurotoxins and Multipotential Toxins Interacting with Neuronal Cells

(2010) Michel R. Popoff et al.   Toxins

Analgesic effects of intra-articular botulinum toxin Type B in a murine model of chronic degenerative knee arthritis pain

(2010) Stephanie Anderson et al.   Journal of Pain Research

Effect of Botulinum Toxin Type A on Transforming Growth Factor β1 in Fibroblasts Derived from Hypertrophic Scar: A Preliminary Report

(2009) Zhibo Xiao et al.   AESTHETIC PLASTIC SURGERY

Effect of transdermal botulinum toxin on sweat secretion in subjects with idiopathic palmar hyperhidrosis

(2009) A. Chow et al.   BRITISH JOURNAL OF DERMATOLOGY

Effect of Botulinum Toxin Type A on a Rat Surgical Wound Model

(2009) Byung-Joo Lee et al.   Clinical and Experimental Otorhinolaryngology

Distribution of the High-Affinity Binding Site and Intracellular Target of Botulinum Toxin Type A in the Human Bladder

(2009) Ana Coelho et al.   EUROPEAN UROLOGY

Urodynamic and Immunohistochemical Evaluation of Intravesical Botulinum Toxin A Delivery Using Liposomes

(2009) Yao-Chi Chuang et al.   JOURNAL OF UROLOGY

Botulinum A Toxin/Dimethyl Sulfoxide Bladder Instillations for Women With Refractory Idiopathic Detrusor Overactivity: A Phase 1/2 Study

(2009) Steven P. Petrou et al.   MAYO CLINIC PROCEEDINGS

Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg

(2009) Luca Carli et al.   MUSCLE & NERVE

Fifteen-Year Experience in Treating Blepharospasm with Botox or Dysport: Same Toxin, Two Drugs

(2009) A. R. Bentivoglio et al.   NEUROTOXICITY RESEARCH

Pain Behavior Measures to Quantitate Joint Pain and Response to Neurotoxin Treatment in Murine Models of Arthritis

(2009) Hollis E. Krug et al.   PAIN MEDICINE

NeuroBloc®/Myobloc®: Unique features and findings

(2009) Joseph C. Arezzo   TOXICON

Quantitative determination of biological activity of botulinum toxins utilizing compound muscle action potentials (CMAP), and comparison of neuromuscular transmission blockage and muscle flaccidity among toxins

(2009) Yasushi Torii et al.   TOXICON

Minimally invasive application of botulinum toxin A in patients with idiopathic rhinitis

(2009) Saskia Rohrbach et al.   Head & Face Medicine

Novel Topical BoNTA (CosmeTox, Toxin Type A) Cream Used to Treat Hyperfunctional Wrinkles of the Face, Mouth, and Neck

(2008) I. Chajchir et al.   AESTHETIC PLASTIC SURGERY

Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation

(2008) Alvaro Lucioni et al.   BJU INTERNATIONAL

Intravesical Botulinum Toxin A Administration Inhibits COX-2 and EP4 Expression and Suppresses Bladder Hyperactivity in Cyclophosphamide-Induced Cystitis in Rats

(2008) Yao-Chi Chuang et al.   EUROPEAN UROLOGY

Botox produces functional weakness in non-injected muscles adjacent to the target muscle

(2008) M. Yaraskavitch et al.   JOURNAL OF BIOMECHANICS

Biological activity of two botulinum toxin type A complexes (Dysport® and Botox®) in volunteers

(2008) K. Wohlfarth et al.   JOURNAL OF NEUROLOGY

Long-Distance Retrograde Effects of Botulinum Neurotoxin A

(2008) F. Antonucci et al.   JOURNAL OF NEUROSCIENCE

Transdermal drug delivery

(2008) Mark R Prausnitz et al.   NATURE BIOTECHNOLOGY

Attomolar Detection of Botulinum Toxin Type A in Complex Biological Matrices

(2008) Karine Bagramyan et al.   PLoS One