Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

(2017) Liang Tao et al.   Nature Communications

Identification and characterization of a novel botulinum neurotoxin

(2017) Sicai Zhang et al.   Nature Communications

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

(2017) Michael Peck et al.   Toxins

Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C

(2017) Roger M. Benoit et al.   Scientific Reports

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1

(2016) S. Mahrhold et al.   BIOCHEMICAL JOURNAL

Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A

(2016) Christoffer Hamark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons

(2016) Ewa Bomba-Warczak et al.   Cell Reports

Clinical differences between A1 and A2 botulinum toxin subtypes

(2015) Ryuji Kaji   TOXICON

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Comparison between botulinum neurotoxin type A2 and type A1 by electrophysiological study in healthy individuals

(2014) Yohei Mukai et al.   TOXICON

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

(2013) Roger M. Benoit et al.   NATURE

Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

(2013) Ronnie Per-Arne Berntsson et al.   STRUCTURE

Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

(2012) Lisheng Peng et al.   JOURNAL OF CELL SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Beltless Translocation Domain of Botulinum Neurotoxin A Embodies a Minimum Ion-conductive Channel

(2011) Audrey Fischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance Factor

(2011) Matthew W. Vetting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

(2011) Lisheng Peng et al.   PLoS Pathogens

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

Structural Analysis of Botulinum Neurotoxin Type G Receptor Binding,

(2010) John Schmitt et al.   BIOCHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

(2009) Zhuji Fu et al.   BIOCHEMISTRY

Crystal contacts as nature's docking solutions

(2009) Evgeny Krissinel   JOURNAL OF COMPUTATIONAL CHEMISTRY

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

(2009) Andreas Rummel et al.   JOURNAL OF NEUROCHEMISTRY

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

(2008) Pål Stenmark et al.   PLoS Pathogens