Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

(2020) Kwok-ho Lam et al.   Cell Reports

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

(2020) Jacqueline M. Tremblay et al.   Toxins

Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins

(2019) Michael James Mansfield et al.   Scientific Reports

The Therapeutic Potential of Nanobodies

(2019) Ivana Jovčevska et al.   BIODRUGS

Tables of Toxicity of Botulinum and Tetanus Neurotoxins

(2019) Ornella Rossetto et al.   Toxins

The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA

(2019) Yongfeng Fan et al.   Toxins

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes

(2018) Consuelo Garcia-Rodriguez et al.   Toxins

The Expanding Therapeutic Utility of Botulinum Neurotoxins

(2018) Elena Fonfria et al.   Toxins

Botulinum and Tetanus Neurotoxins

(2018) Min Dong et al.   Annual Review of Biochemistry

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

(2018) Kwok-ho Lam et al.   Nature Communications

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics

(2018) Jonathan Davies et al.   Toxins

Identification and characterization of a novel botulinum neurotoxin

(2017) Sicai Zhang et al.   Nature Communications

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

(2017) Michael Peck et al.   Toxins

Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook

(2017) Mehdi Arbabi-Ghahroudi   Frontiers in Immunology

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

(2017) Peter Bannas et al.   Frontiers in Immunology

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding

(2017) Guorui Yao et al.   Scientific Reports

On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments

(2016) Marco Pirazzini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Camelid nanobodies: killing two birds with one stone

(2015) Aline Desmyter et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin

(2015) Kwok-Ho Lam et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

On Botulinum Neurotoxin Variability: TABLE 1 

(2015) Cesare Montecucco et al.   mBio

An Atypical Outbreak of Food-Borne Botulism Due to Clostridium botulinum Types B and E from Ham

(2014) Christelle Mazuet et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain

(2013) Marco Pirazzini et al.   FEBS LETTERS

Molecular Characterization of a Novel Botulinum Neurotoxin Type H Gene

(2013) Nir Dover et al.   JOURNAL OF INFECTIOUS DISEASES

Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

(2013) Ronnie Per-Arne Berntsson et al.   STRUCTURE

Structure of dual receptor binding to botulinum neurotoxin B

(2013) Ronnie P-A. Berntsson et al.   Nature Communications

Botulinum Neurotoxins B and E Translocate at Different Rates and Exhibit Divergent Responses to GT1b and Low pH

(2012) Shihu Sun et al.   BIOCHEMISTRY

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba

(2012) Matthias Michalek et al.   Nature Chemical Biology

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Studies of the Mechanistic Details of the pH-dependent Association of Botulinum Neurotoxin with Membranes

(2011) Darren J. Mushrush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beltless Translocation Domain of Botulinum Neurotoxin A Embodies a Minimum Ion-conductive Channel

(2011) Audrey Fischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Type E botulism

(2010) B Zane Horowitz   CLINICAL TOXICOLOGY

A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region

(2010) Jianbo Dong et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system

(2010) Y. C. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin

(2010) C. Garcia-Rodriguez et al.   PROTEIN ENGINEERING DESIGN & SELECTION

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F

(2009) Rakhi Agarwal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics

(2008) Jiafu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation

(2008) Desigan Kumaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

(2008) Pål Stenmark et al.   PLoS Pathogens

Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease

(2008) Audrey Fischer et al.   PLoS Pathogens