Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E

Neuronal selectivity of botulinum neurotoxins

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Clinical duration of action of different botulinum toxin types in humans

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Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors

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Safety and pharmacodynamics of a novel recombinant botulinum toxin E (rBoNT-E): Results of a phase 1 study in healthy male subjects compared with abobotulinumtoxinA (Dysport®)

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The Expanding Therapeutic Utility of Botulinum Neurotoxins

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Safety and Efficacy of EB-001, a Novel Type E Botulinum Toxin, in Subjects with Glabellar Frown Lines

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Identification and characterization of a novel botulinum neurotoxin

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Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

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Comparative genomic analyses reveal broad diversity in botulinum-toxin-producing Clostridia

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Gangliosides of the Vertebrate Nervous System

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Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A

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N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

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N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

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Glycoblocks: a schematic three-dimensional representation for glycans and their interactions

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Privateer: software for the conformational validation of carbohydrate structures

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Privateer: software for the conformational validation of carbohydrate structures

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Deciphering key features in protein structures with the new ENDscript server

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How good are my data and what is the resolution?

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Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E

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Structure of dual receptor binding to botulinum neurotoxin B

(2013) Ronnie P-A. Berntsson et al.   Nature Communications

REFMAC5 for the refinement of macromolecular crystal structures

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Unique Ganglioside Recognition Strategies for Clostridial Neurotoxins

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LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

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The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites

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XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

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MolProbity: all-atom structure validation for macromolecular crystallography

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Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

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Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

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Cell entry strategy of clostridial neurotoxins

(2009) Thomas Binz et al.   JOURNAL OF NEUROCHEMISTRY

Membrane Fusion: Grappling with SNARE and SM Proteins

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Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics

(2008) Jiafu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation

(2008) Desigan Kumaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

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