Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress

(2021) Xiaofeng A. Su et al.   GENES & DEVELOPMENT

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Plk1 overexpression induces chromosomal instability and suppresses tumor development

(2018) Guillermo de Cárcer et al.   Nature Communications

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis

(2017) Wei Zhong Leong et al.   GENES & DEVELOPMENT

The cohesin complex prevents Myc-induced replication stress

(2017) Sara Rohban et al.   Cell Death & Disease

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

(2016) Sarah J. Pfau et al.   GENES & DEVELOPMENT

Assessment of megabase-scale somatic copy number variation using single-cell sequencing

(2016) Kristin A. Knouse et al.   GENOME RESEARCH

Myc induced replicative stress response: How to cope with it and exploit it

(2015) Sara Rohban et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

(2015) Jasper Mullenders et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aurora B Overexpression Causes Aneuploidy and p21Cip1Repression during Tumor Development

(2015) Alejandra González-Loyola et al.   MOLECULAR AND CELLULAR BIOLOGY

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC Association with Cancer Risk and a New Model of MYC-Mediated Repression

(2014) M. D. Cole   Cold Spring Harbor Perspectives in Medicine

Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites

(2013) Jian Yan et al.   CELL

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

The transcriptional landscape of αβ T cell differentiation

(2013) Michael Mingueneau et al.   NATURE IMMUNOLOGY

The cancer biology of whole-chromosome instability

(2013) P H G Duijf et al.   ONCOGENE

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

(2012) Dinis Pedro Calado et al.   NATURE IMMUNOLOGY

Functional genomics identifies therapeutic targets for MYC-driven cancer

(2012) M. Toyoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation

(2011) Vlad C. Seitan et al.   NATURE

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

(2010) Liviu Malureanu et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

The TLX1 oncogene drives aneuploidy in T cell transformation

(2010) Kim De Keersmaecker et al.   NATURE MEDICINE

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice

(2009) Roman A. Timakhov et al.   GENES CHROMOSOMES & CANCER

Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

(2009) Min Li et al.   JOURNAL OF CELL BIOLOGY

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression

(2008) María J. Bueno et al.   CANCER CELL

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE