How unfinished business from S-phase affects mitosis and beyond

Portrait of replication stress viewed from telomeres

(2013) Fuyuki Ishikawa   CANCER SCIENCE

Impediments to replication fork movement: stabilisation, reactivation and genome instability

(2013) Sarah Lambert et al.   CHROMOSOMA

Functions of the centromere and kinetochore in chromosome segregation

(2013) Frederick G Westhorpe et al.   CURRENT OPINION IN CELL BIOLOGY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast

(2013) Ulrika Norman-Axelsson et al.   PLoS Genetics

Replication fork dynamics and the DNA damage response

(2012) Rebecca M. Jones et al.   BIOCHEMICAL JOURNAL

Cell-Cycle-Dependent Structural Transitions in the Human CENP-A Nucleosome In Vivo

(2012) Minh Bui et al.   CELL

On the regulation, function, and localization of the DNA-dependent ATPase PICH

(2012) Manuel Kaulich et al.   CHROMOSOMA

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Linking abnormal mitosis to the acquisition of DNA damage

(2012) Neil J. Ganem et al.   JOURNAL OF CELL BIOLOGY

The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy

(2012) Amélie Rodrigue et al.   JOURNAL OF CELL SCIENCE

Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA Complex: A Mechanism for Disentangling Chromosomes

(2012) Petr Cejka et al.   MOLECULAR CELL

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

(2012) Sébastien Rouzeau et al.   PLoS One

The complex basis underlying common fragile site instability in cancer

(2012) Efrat Ozeri-Galai et al.   TRENDS IN GENETICS

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

(2012) Tobias Wijshake et al.   PLoS Genetics

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

On the origins of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   CELL CYCLE

PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution

(2011) Yuwen Ke et al.   EMBO JOURNAL

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Aberrant chromosome morphology in human cells defective for Holliday junction resolution

(2011) Thomas Wechsler et al.   NATURE

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

(2010) Saskia J.E. Suijkerbuijk et al.   CANCER RESEARCH

Replication dynamics at common fragile site FRA6E

(2010) Elisa Palumbo et al.   CHROMOSOMA

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

(2010) Patrizia Vinciguerra et al.   JOURNAL OF CLINICAL INVESTIGATION

PICH and Cotargeted Plk1 Coordinately Maintain Prometaphase Chromosome Arm Architecture

(2010) Yasuhiro Kurasawa et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

A role for recombination in centromere function

(2010) Ramsay J. McFarlane et al.   TRENDS IN GENETICS

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Common fragile sites are characterized by histone hypoacetylation

(2009) Yanwen Jiang et al.   HUMAN MOLECULAR GENETICS

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Bloom's Syndrome Helicase and Mus81 are Required to Induce Transient Double-strand DNA Breaks in Response to DNA Replication Stress

(2007) Tsutomu Shimura et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY