Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans

Xenotransplantation: Current Status in Preclinical Research

(2020) Tianyu Lu et al.   Frontiers in Immunology

The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation

(2020) Alfred Joseph Tector et al.   Frontiers in Immunology

Identification by mass spectrometry and immunoblotting of xenogeneic antigens in the N- and O-glycomes of porcine, bovine and equine heart tissues

(2020) Chunsheng Jin et al.   GLYCOCONJUGATE JOURNAL

Toward acellular xenogeneic heart valve prostheses: Histological and biomechanical characterization of decellularized and enzymatically deglycosylated porcine pulmonary heart valve matrices

(2020) Katja Findeisen et al.   XENOTRANSPLANTATION

Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons

(2020) Yuichi Ariyoshi et al.   XENOTRANSPLANTATION

A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept

(2019) Benyamin Rahmani et al.   Journal of Cardiovascular Translational Research

Approach for Profiling of Glycosphingolipid Glycosylation by Multiplexed Capillary Gel Electrophoresis Coupled to Laser-Induced Fluorescence Detection To Identify Cell-Surface Markers of Human Pluripotent Stem Cells and Derived Cardiomyocytes

(2019) Charlotte Rossdam et al.   ANALYTICAL CHEMISTRY

Triple ( GGTA1, CMAH, B2M ) modified pigs expressing an SLA class‐I low phenotype – effects on immune status and susceptibility to human immune responses

(2019) Rabea Hein et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2

(2019) Konrad Fischer et al.   XENOTRANSPLANTATION

Decellularization combined with enzymatic removal of N‐linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model

(2019) Robert Ramm et al.   XENOTRANSPLANTATION

Capillary Electrophoresis Separations of Glycans

(2018) Grace Lu et al.   CHEMICAL REVIEWS

Xenotransplantation: back to the future?

(2018) Raphael P. H. Meier et al.   TRANSPLANT INTERNATIONAL

Glycosphingolipids of porcine, bovine, and equine pericardia as potential immune targets in bioprosthetic heart valve grafts

(2018) Angela Barone et al.   XENOTRANSPLANTATION

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Different approaches to heart valve decellularization: A comprehensive overview of the past 30 years

(2017) Filippo Naso et al.   XENOTRANSPLANTATION

Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves

(2016) Karolina Theodoridis et al.   Acta Biomaterialia

Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies

(2016) Robert Ramm et al.   BASIC RESEARCH IN CARDIOLOGY

Engineering natural heart valves: possibilities and challenges

(2016) Mehrnaz Namiri et al.   Journal of Tissue Engineering and Regenerative Medicine

Efficient production of biallelicGGTA1knockout pigsbycytoplasmic microinjection of CRISPR/Cas9 into zygotes

(2016) Bjoern Petersen et al.   XENOTRANSPLANTATION

Characterization of immunogenic Neu5Gc in bioprosthetic heart valves

(2016) Eliran Moshe Reuven et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

The immunological barriers to xenotransplantation

(2015) M. Vadori et al.   TISSUE ANTIGENS

Expression of NeuGc on pig heart valves

(2015) Whayoung Lee et al.   XENOTRANSPLANTATION

Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research

(2014) Jennifer E. Huffman et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of acid and non-acid glycosphingolipids of porcine heart valve cusps as potential immune targets in biological heart valve grafts

(2014) Angela Barone et al.   XENOTRANSPLANTATION

Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation

(2014) Apolline Salama et al.   XENOTRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

The sweets standing at the borderline between allo- and xenotransplantation

(2013) Kyoung-Soon Jang et al.   XENOTRANSPLANTATION

N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens

(2013) Christopher Burlak et al.   XENOTRANSPLANTATION

First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses

(2013) Filippo Naso et al.   XENOTRANSPLANTATION

An overview of tissue and whole organ decellularization processes

(2011) Peter M. Crapo et al.   BIOMATERIALS

Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era1

(2011) Michael E. Breimer   XENOTRANSPLANTATION

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Choice of Prosthetic Heart Valve in Adults

(2010) Shahbudin H. Rahimtoola   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Complement regulation in the GalT KO era

(2010) Shuji Miyagawa et al.   XENOTRANSPLANTATION

Structural characterization of α1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies

(2010) Mette Diswall et al.   XENOTRANSPLANTATION

Investigation of potential carbohydrate antigen targets for human and baboon antibodies

(2010) Peter Yeh et al.   XENOTRANSPLANTATION

Bioprosthetic heart valves: modes of failure

(2009) Raheela Fareed Siddiqui et al.   HISTOPATHOLOGY

The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope: A carbohydrate of unique evolution and clinical relevance

(2007) Bruce A. Macher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS