Decellularization combined with enzymatic removal of N‐linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model

In vivo performance of freeze-dried decellularized pulmonary heart valve allo- and xenografts orthotopically implanted into juvenile sheep

(2018) Tobias Goecke et al.   Acta Biomaterialia

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

(2018) Runjie Zhang et al.   Acta Biomaterialia

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Impact of T-cell-mediated immune response on xenogeneic heart valve transplantation: short-term success and mid-term failure

(2017) Anna C Biermann et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves

(2016) Karolina Theodoridis et al.   Acta Biomaterialia

Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies

(2016) Robert Ramm et al.   BASIC RESEARCH IN CARDIOLOGY

Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience

(2016) Samir Sarikouch et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

The impact of decellularization agents on renal tissue extracellular matrix

(2016) Nafiseh Poornejad et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Xenotransplantation makes a comeback

(2016) Jeffrey M Perkel   NATURE BIOTECHNOLOGY

Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep

(2015) Karolina Theodoridis et al.   BIOMATERIALS

Sucrose Diffusion in Decellularized Heart Valves for Freeze-Drying

(2015) Shangping Wang et al.   TISSUE ENGINEERING PART C-METHODS

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Recent investigations into pig antigen and anti-pig antibody expression

(2015) Guerard W. Byrne et al.   International Journal of Surgery

Optimization and Critical Evaluation of Decellularization Strategies to Develop Renal Extracellular Matrix Scaffolds as Biological Templates for Organ Engineering and Transplantation

(2014) M. Caralt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Successful re-endothelialization of a perfusable biological vascularized matrix (BioVaM) for the generation of 3D artificial cardiac tissue

(2014) Birgit Andrée et al.   BASIC RESEARCH IN CARDIOLOGY

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

(2014) Muhammad M. Mohiuddin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts

(2013) Igor Tudorache et al.   TISSUE ENGINEERING PART A

Porcine bioprosthetic heart valves: The next generation

(2012) Rizwan A. Manji et al.   AMERICAN HEART JOURNAL

Early and late failure of tissue-engineered pulmonary valve conduits used for right ventricular outflow tract reconstruction in patients with congenital heart disease

(2012) G. Perri et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults: Early Report

(2011) S. Cebotari et al.   CIRCULATION

Early obstruction of decellularized xenogenic valves in pediatric patients: involvement of inflammatory and fibroproliferative processes

(2010) Iwona Cicha et al.   CARDIOVASCULAR PATHOLOGY

Early failure of xenogenous de-cellularised pulmonary valve conduits — a word of caution!☆

(2010) André Rüffer et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Bioprosthetic heart valves: modes of failure

(2009) Raheela Fareed Siddiqui et al.   HISTOPATHOLOGY

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE