Strategies and Challenges in Clinical Trials Targeting Human Aging

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

(2016) Michael B. Stout et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease

(2015) A. M. Orogo et al.   CIRCULATION RESEARCH

Clinical strategies and animal models for developing senolytic agents

(2015) James L. Kirkland et al.   EXPERIMENTAL GERONTOLOGY

High-throughput screening approaches to identify regulators of mammalian autophagy

(2015) Justin Joachim et al.   METHODS

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Trial for the ages

(2015) S. S. Hall   SCIENCE

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Bioenergetics and Mitochondrial Dysfunction in Aging: Recent Insights for a Therapeutical Approach

(2014) Antonino Romano et al.   CURRENT PHARMACEUTICAL DESIGN

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

(2014) Gabriella Testa et al.   CURRENT PHARMACEUTICAL DESIGN

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

(2014) C. A. Bannister et al.   DIABETES OBESITY & METABOLISM

How to Use a Subgroup Analysis

(2014) Xin Sun et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Intention-to-Treat Principle

(2014) Michelle A. Detry et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

AMPK activation—protean potential for boosting healthspan

(2013) Mark F. McCarty   AGE

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Salicylate (Salsalate) in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

ENDOCRINE SIDE EFFECTS OF ANTI-CANCER DRUGS: Effects of anti-cancer targeted therapies on lipid and glucose metabolism

(2013) Bruno Vergès et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

(2013) Qin-Li Wan et al.   EXPERIMENTAL GERONTOLOGY

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Do Changes in Circulating Biomarkers Track With Each Other and With Functional Changes in Older Adults?

(2013) J. L. Sanders et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The GH/IGF-1 axis in ageing and longevity

(2013) Riia K. Junnila et al.   Nature Reviews Endocrinology

Bevacizumab for Advanced Breast Cancer: Hope, Hype, and Hundreds of Headlines

(2013) M. Fralick et al.   ONCOLOGIST

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity

(2012) Ariela Benigni et al.   AGE

Adverse events associated with mTOR inhibitors

(2012) Nicolas Pallet et al.   Expert Opinion On Drug Safety

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

Mobility Stress Test Approach to Predicting Frailty, Disability, and Mortality in High-Functioning Older Adults

(2012) Joe Verghese et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

The Prevention and Treatment of Missing Data in Clinical Trials

(2012) Roderick J. Little et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Metformin Improves Immunosuppressant Induced Hyperglycemia and Exocrine Apoptosis in Rats

(2012) Vijay Shivaswamy et al.   TRANSPLANTATION

Angiotensin II Receptor Blockers and Risk of Cancer in Patients With Systemic Hypertension

(2011) Chin-Chou Huang et al.   AMERICAN JOURNAL OF CARDIOLOGY

A nationwide study of aspirin, other non-steroidal anti-inflammatory drugs and Hodgkin lymphoma risk in Denmark

(2011) E T Chang et al.   BRITISH JOURNAL OF CANCER

Use of Angiotensin Receptor Blockers and the Risk of Cancer

(2011) Björn Pasternak et al.   CIRCULATION

Hospitalization-Associated Disability

(2011) Kenneth E. Covinsky et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Examining the Evidence: A Systematic Review of the Inclusion and Analysis of Older Adults in Randomized Controlled Trials

(2011) Donna M. Zulman et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

(2011) John Burn et al.   LANCET

Can spiral analysis predict the FP-CIT SPECT scan result in tremulous patients?

(2011) Nin P.S. Bajaj et al.   MOVEMENT DISORDERS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials

(2010) Ilke Sipahi et al.   LANCET ONCOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Are There Effects of Renin–Angiotensin System Antagonists Beyond Blood Pressure Control?

(2009) George Bakris   AMERICAN JOURNAL OF CARDIOLOGY

Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

(2009) Edson Lucas Santos et al.   BIOCHEMICAL PHARMACOLOGY

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label study

(2009) Olivier Hanon et al.   JOURNAL OF HYPERTENSION

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Visceral adipose tissue modulates mammalian longevity

(2008) Radhika Muzumdar et al.   AGING CELL

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE